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pro vyhledávání: '"Lindsay M Roth"'
Autor:
Hubert Monnerie, Micah Romer, Lindsay M. Roth, Caela Long, John S. Millar, Kelly L. Jordan-Sciutto, Judith B. Grinspan
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent, in particular HIV-associated neurocognitive disorders (HANDs). White matter damage persists
Externí odkaz:
https://doaj.org/article/d47bdc2e2ecf4e7fa6028db6e43612a6
Autor:
Lindsay K. Festa, Abigail E. Clyde, Caela C. Long, Lindsay M. Roth, Judith B. Grinspan, Kelly L. Jordan-Sciutto
Publikováno v:
Journal of Neurochemistry. 165:722-740
White matter deficits are a common neuropathologic finding in neurologic disorders, including HIV-associated neurocognitive disorders (HAND). In HAND, the persistence of white matter alterations despite suppressive antiretroviral (ARV) therapy sugges
Publikováno v:
Glia
Despite combined antiretroviral therapy (cART), HIV-associated neurocognitive disorder (HAND) affects 30-50% of HIV-positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white mat
Autor:
Eunjoo Lancaster, Marina Bakay, Danielle Harrington, Hakon Hakonarson, Rahul Pandey, William W. Motley, Bryan Strenkowski, Lindsay M Roth, Jian Li, Micah Romer, Judith B. Grinspan, Steven S. Scherer, Heather S. Hain
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout, Clec16aΔUBC mice, to investigate t
Autor:
Brigid K. Jensen, Jonathan D. Geiger, Lindsay M Roth, Judith B. Grinspan, Lindsay Festa, Kelly L. Jordan-Sciutto
Publikováno v:
J Neuroimmune Pharmacol
Despite the introduction of antiretroviral (ARV) therapy (ART), approximately 30-50% of people living with human immunodeficiency virus-1 (HIV-1) will develop a spectrum of measurable neurocognitive dysfunction, collectively called HIV-associated neu
Publikováno v:
Brain Res
While the severe cognitive effects of HIV-associated dementia have been reduced by combined antiretroviral therapy (cART), nearly half of HIV-positive (HIV+) patients still suffer from some form of HIV-Associated Neurocognitive Disorders (HAND). Whil