Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Lindsay Lambert"'
Autor:
Lucas Rodrigues, Joshua Watson, Yuan Feng, Benjamin Lewis, Garrett Harvey, Gerald Post, Kate Megquier, Michelle E. White, Lindsay Lambert, Aubrey Miller, Christina Lopes, Shaying Zhao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose muta
Externí odkaz:
https://doaj.org/article/c998cd0c12a6457ab3eb8c99d28fbd9f
Autor:
Kevin Wu, Lucas Rodrigues, Gerald Post, Garrett Harvey, Michelle White, Aubrey Miller, Lindsay Lambert, Benjamin Lewis, Christina Lopes, James Zou
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Spontaneous tumors in canines share significant genetic and histological similarities with human tumors, positioning them as valuable models to guide drug development. However, current translational studies have limited real world evidence a
Externí odkaz:
https://doaj.org/article/cf89db7ea3b249079ea3a3ed75c25e22
Autor:
Timothy Estabrooks, Anastasia Gurinovich, Jodie Pietruska, Benjamin Lewis, Garrett Harvey, Gerald Post, Lindsay Lambert, Lucas Rodrigues, Michelle E. White, Christina Lopes, Cheryl A. London, Kate Megquier
BackgroundCanine hemangiosarcoma (HSA) is an aggressive cancer of endothelial cells associated with short survival times. Understanding the genomic landscape of HSA is critical to developing more effective therapeutic strategies.ObjectivesTo determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f96009aded31948f9bd6dc93541ec9
https://doi.org/10.1101/2022.11.17.516327
https://doi.org/10.1101/2022.11.17.516327
Autor:
Michelle E. White, Garrett Harvey, Lucas Rodrigues, Chase Schwalbach, Dorothy Girimonte, Aubrey Miller, Abigail Hull, Lindsay Lambert, Christina Lopes, Gerald Post
Publikováno v:
Molecular Cancer Research. 21:A005-A005
Canine cancer patients represent an important translational model for human cancer research with their spontaneous tumor pathogenesis and the many histological, genetic, molecular and clinical similarities between canine and human tumors. Canine tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28c805db9aa0762789ecdeefcbcda0c2
https://doi.org/10.1158/1557-3125.ras23-a005
https://doi.org/10.1158/1557-3125.ras23-a005
Autor:
Chase Schwalbach, Lucas Rodrigues, Garrett Harvey, Dorothy Girimonte, Gerald Post, Lindsay Lambert, Aubrey Miller, Abigail Hull, Christina Lopes, Michelle E. White
Publikováno v:
Cancer Research. 83:934-934
In recent years, clinico-genomic databases integrating real-world data (RWD) from electronic health records and tumor genomic profiles have been used to expedite development of new, precision medicine therapies for cancer treatment. Clinical trials i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb243e85265065d6d38fac274c8c059
https://doi.org/10.1158/1538-7445.am2023-934
https://doi.org/10.1158/1538-7445.am2023-934
Autor:
Lucas Rodrigues, Thaynan Vieira, Garrett Harvey, Dorothy Girimonte, Gerald Post, Lindsay Lambert, Aubrey Miller, Abigail Hull, Chase Schwalbach, Christina Lopes, Michelle White
Publikováno v:
Cancer Research. 83:55-55
Skin tumors are the most common type of neoplastic lesion affecting humans and dogs, and their incidence is increasing for both species. Skin tumor initiation and progression are associated with chronic exposure to ultraviolet (UV) radiation, mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32effacd9ab2535cb55ec9ac1bec14b0
https://doi.org/10.1158/1538-7445.am2023-55
https://doi.org/10.1158/1538-7445.am2023-55
Autor:
Christina Lopes, Lindsay Lambert, Kate Megquier, Yuan Feng, Gerald Post, Garrett Harvey, Aubrey L. Miller, Lucas S. Rodrigues, Benjamin P. Lewis, Joshua Watson, Shaying Zhao
Naturally occurring canine cancers have remarkable similarities to their human counterparts. In order to determine whether these similarities occur at the molecular level, we investigated hotspot mutations in a variety of spontaneously arising canine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d3ce41838b9309b4f347ff27f9d6a5
https://doi.org/10.1101/2021.10.22.465469
https://doi.org/10.1101/2021.10.22.465469
Autor:
Kevin Wu, Lucas Rodrigues, Gerald Post, Garrett Harvey, Aubrey Miller, Lindsay Lambert, Christina Lopes, Benjamin Lewis, James Zou
Publikováno v:
Cancer Research. 82:635-635
Spontaneous tumors in dogs are highly similar to human cancers histologically, genetically, molecularly and clinically. In this presentation we explore similarities found across species when associating cancer biomarkers and outcomes. Our findings va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f0bb3de98176905af0422c65c7ec5b
https://doi.org/10.1158/1538-7445.am2022-635
https://doi.org/10.1158/1538-7445.am2022-635
Autor:
Aubrey L. Miller, Gerry Post, Garrett Harvey, Benjamin Lewis, Lucas Rodrigues, Christina Lopes, Lindsay Lambert, Rilke Van Buren
Publikováno v:
Cancer Research. 81:2991-2991
BRCA1 and BRCA2 (Breast cancer susceptibility gene 1 and 2) are tumor suppressor genes that maintain genomic stability by repairing damaged DNA. The proteins coded by these genes are involved in complexes that activate the repair of double strand bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165f1c73834efc30ceaf3873ad4aaf90
https://doi.org/10.1158/1538-7445.am2021-2991
https://doi.org/10.1158/1538-7445.am2021-2991