Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lindsay L. Jones"'
Autor:
Christophe Bourdeaux, Paméla Chéou, Mohamed F. Mandour, Mélanie Gaignage, Jacques Van Snick, Lindsay L. Jones, Catherine Uyttenhove, Dario A. A. Vignali, Jean-Paul Coutelier
Publikováno v:
European Journal of Immunolgy, Vol. 51, no.6, p. 1482-1493 (2021)
The dimeric cytokine IL-12 is important in the control of various infections but also contributes to the pathology of certain diseases making it a potential target for therapy. However, its specific inhibition with antibodies is complicated by the fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edb6e6d82cf064498184496b7f1e8aa
https://pubmed.ncbi.nlm.nih.gov/33788263
https://pubmed.ncbi.nlm.nih.gov/33788263
Autor:
Christophe Bourdeaux, Paméla Chéou, Lindsay L. Jones, Mohamed F. Mandour, Catherine Uyttenhove, Jacques Van Snick, Dario A. A. Vignali, Jean-Paul Coutelier, Mélanie Gaignage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e996b304d5790a5985088ebb980c7828
https://doi.org/10.1002/eji.202048936/v2/response1
https://doi.org/10.1002/eji.202048936/v2/response1
Autor:
Andrea L. Szymczak-Workman, Lindsay L. Jones, Clifford S. Guy, Dario A.A. Vignali, Vivian Kitainda
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd7bde3d59c00cfefee2179e5fd61d2
https://doi.org/10.1016/b978-0-12-819460-7.00203-6
https://doi.org/10.1016/b978-0-12-819460-7.00203-6
Autor:
Caitlin C. Zebley, Wenting Zheng, Terrence L. Geiger, Jayadev Mavuluri, Benjamin Youngblood, Yong-Dong Wang, Lindsay L. Jones, Lingyun Long, Yiping Fan, Hongbo Chi, Jun Wei, Yogesh Dhungana
Publikováno v:
Blood
Chimeric antigen receptor (CAR)–T-cell therapeutic efficacy is associated with long-term T-cell persistence and acquisition of memory. Memory-subset formation requires T-cell factor 1 (TCF-1), a master transcription factor for which few regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca502bac36815990017d6ae3081fae2
https://pubmed.ncbi.nlm.nih.gov/35323877
https://pubmed.ncbi.nlm.nih.gov/35323877
Publikováno v:
The Journal of Immunology. 201:2934-2946
IL-6 is a critical driver of acute and chronic inflammation and has been reported to act as a T cell survival factor. The influence of IL-6 on T cell homeostasis is not well resolved. We demonstrate that IL-6 signaling drives T cell expansion under i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736495624e3426689578ec1595fb7c9f
https://doi.org/10.4049/jimmunol.1800016
https://doi.org/10.4049/jimmunol.1800016
Autor:
Terrence L. Geiger, Hossam A. Abdelsamed, Ben Youngblood, Rajshekhar Alli, Carol E. O’Hear, Jacob Halum Basham, Wenting Zheng, Lance E. Palmer, Lindsay L. Jones
Publikováno v:
Leukemia. 32:1157-1167
In vivo persistence of chimeric antigen receptor (CAR)-modified T cells correlates with therapeutic efficacy, yet CAR-specific factors that support persistence are not well resolved. Using a CD33-specific CAR in an acute myeloid leukemia (AML) model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa10d9770eb0ca375d0915d8fd302e66
https://doi.org/10.1038/s41375-017-0008-6
https://doi.org/10.1038/s41375-017-0008-6
Publikováno v:
The Journal of Immunology. 196:2973-2985
How a large number of cytokines differentially signal through a small number of signal transduction pathways is not well resolved. This is particularly true for IL-6 and IL-10, which act primarily through STAT3 yet induce dissimilar transcriptional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a35aec07f64a67c0290fc56e5428ee
https://doi.org/10.4049/jimmunol.1402953
https://doi.org/10.4049/jimmunol.1402953
Publikováno v:
Scientific Reports
Although the TCR repertoire is highly diverse, a small fraction of TCR chains, referred to as public, preferentially form and are shared by most individuals. Prior studies indicated that public TCRβ may be preferentially deployed in autoimmunity. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adb7d20070eba002f38e9eab8b2f56e
Autor:
Dario A. A. Vignali, Lindsay L. Jones
Publikováno v:
Immunologic Research. 51:5-14
Production of cytokines by immune cells in response to stimuli and the binding of cytokines to specific receptors on target cells is a central feature of the immune response. The IL-12 cytokine family is particularly influential in determining the fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede1decb85105dac42da22228cbea761
https://doi.org/10.1007/s12026-011-8209-y
https://doi.org/10.1007/s12026-011-8209-y
Autor:
Yi-Gui Gao, Alexander J. Bankovich, Lindsay L. Jones, Raven H. Huang, Leremy A. Colf, David M. Kranz, Jennifer D. Stone, K.C Garcia, C.M Chan
Publikováno v:
Biochemistry. 47:12398-12408
To understand the mechanisms that govern T cell receptor (TCR)-peptide MHC (pMHC) binding and the role that different regions of the TCR play in affinity and antigen specificity, we have studied the TCR from T cell clone 2C. High-affinity mutants of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14d6e0870c3544dfc62990586fdb934
https://doi.org/10.1021/bi801349g
https://doi.org/10.1021/bi801349g