Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lindsay J. Edwards"'
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
The kinetic parameters governing T cell activation have been intensely studied for over a decade. However, the details of how the various aspects of receptor:ligand interactions culminate in T cell activation remains shrouded in mystery. Initial meas
Externí odkaz:
https://doaj.org/article/77daa34bd9b44c1facd3804886139682
Autor:
Kristen M Rosenthal, Lindsay J Edwards, Joseph J Sabatino, Jennifer D Hood, Heather A Wasserman, Cheng Zhu, Brian D Evavold
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32562 (2012)
T cells recognizing self-peptides that mediate autoimmune disease and those that are responsible for efficacious immunity against pathogens may differ in affinity for antigen due to central and peripheral tolerance mechanisms. Here we utilize prototy
Externí odkaz:
https://doaj.org/article/d9c7abbdc78e4097a30a66f872f5aabd
Publikováno v:
Clinical Immunology. 158:221-230
The transcription factor STAT3 is overexpressed and hyperactivated in T cells from SLE patients. STAT3 plays a central role in T cell differentiation into Th17 and T follicular helper cells, two subsets that orchestrate autoimmune responses in SLE. M
Autor:
Lindsay J. Edwards, Brian D. Evavold
Publikováno v:
Immunologic Research. 50:39-48
T cell recognition of antigen is a crucial aspect of the adaptive immune response. One of the most common means of pathogen immune evasion is mutation of T cell epitopes. T cell recognition of such ligands can result in a variety of outcomes includin
Autor:
Brian D. Evavold, Lindsay J. Edwards
Publikováno v:
Cellular Immunology. 261:64-68
The functional outcomes of the T cell’s interaction with the peptide:MHC complex can be dramatically altered by the introduction of a single amino acid substitution. Previous studies have described the varied effects of these altered peptide ligand
Publikováno v:
The Journal of Immunology. 181:1760-1766
Current models of T cell activation focus on the kinetics of TCR-ligand interactions as the central parameter governing T cell responsiveness. However, these kinetic parameters do not adequately predict all T cell behavior, particularly the response
In this study, we investigate the basis of T cell recognition of myelin that governs the progression from acute symptoms into disease remission, relapse, and chronic progression in a secondary progressive model of demyelinating disease. Until now, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fedb50a4aa2864f330fa788cbd50dd7
https://europepmc.org/articles/PMC4201951/
https://europepmc.org/articles/PMC4201951/
Autor:
Lindsay J. Edwards, Brian D. Evavold
Autoreactive T cells are responsible for inducing several autoimmune diseases, including type 1 diabetes. We have developed a strategy to induce unresponsiveness in these cells by destabilizing the peptide:MHC ligand recognized by the T cell receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a69c332e06fe986b0924fb306f8c6a5
https://europepmc.org/articles/PMC4465239/
https://europepmc.org/articles/PMC4465239/
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Frontiers in Immunology
Frontiers in Immunology
The T cell receptor (TCR) interacts with peptide-major histocompatibility complex (pMHC) to enable T cell development and trigger adaptive immune responses. For this reason, TCR:pMHC interactions have been intensely studied for over two decades. Howe
Autor:
Brian D. Evavold, Jun Huang, Lindsay J. Edwards, Baoyu Liu, Cheng Zhu, Veronika I. Zarnitsyna, Ning Jiang
Publikováno v:
Nature
The T cell receptor (TCR) interacts with peptide-major histocompatibility complexes (pMHC) to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct physical contact is required between the T cell and the antigen-pres