Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lindsay J. Bischoff"'
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ
Autor:
Sandra Schrenk, Lindsay J. Bischoff, Jillian Goines, Yuqi Cai, Shruti Vemaraju, Yoshinobu Odaka, Samantha R. Good, Joseph S. Palumbo, Sara Szabo, Damien Reynaud, Catherine D. Van Raamsdonk, Richard A. Lang, Elisa Boscolo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Life-threatening vascular tumors can be associated with uncontrolled activity of the guanine nucleotide-binding protein subunit alpha (Gαq). Here, the authors develop a murine model for these tumors and show that MEK inhibition prevents formation of
Externí odkaz:
https://doaj.org/article/7cad600490c342d6b140a087bcb306ca
Autor:
Hitesh Deshmukh, Paul L. Dudas, Jaclyn W. McAlees, Dasom Kim, Davinder Kaur, Lindsay J. Bischoff, Ian P. Lewkowich, Xenia Davis, Julie Hargis, Jerilyn Gray, Lauren K. Houshel
Background Recent studies have demonstrated that Th2 responses have the ability to antagonize Th17 responses. In mouse models of allergic asthma, blockade of Th2-effector cytokines results in elaboration of Th17 responses and associated increases in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d50222eb1cea82a30fd32cc2f1a0d7
https://europepmc.org/articles/PMC6393183/
https://europepmc.org/articles/PMC6393183/
