The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life

Autor: Sarah Phillips, Rachel Watt, Thomas Atkinson, George M Savva, Antonietta Hayhoe, Lindsay J Hall, on behalf of the PEARL study team

Publikováno v: BMC Pediatrics, Vol 21, Iss 1, Pp 1-11 (2021)

Abstract Background The early life period represents the first step in establishing a beneficial microbial ecosystem, which in turn affects both short and longer-term health. Changes during pregnancy influence the neonatal microbiome; through transmi

Externí odkaz: https://doaj.org/article/8b202f855dfa4487bab3d112f65e7165

Development and characterization of an enhanced nonviral expression vector for electroporation cancer treatment

Autor: Patrick F Forde, Lindsay J Hall, Mira Sadadcharam, Marcle de Kruijf, Gerald C O'Sullivan, Declan M Soden

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Nonviral plasmid DNA gene therapy represents a promising approach for the treatment of many diseases including cancer. Intracellular delivery of DNA can be achieved with the application of electroporation, which facilitates the initial transport of e

Externí odkaz: https://doaj.org/article/41ba104c43a147a0a16e7e102d481248

Exclusively breastmilk‐fed preterm infants are at high risk of developing subclinical vitamin K deficiency despite intramuscular prophylaxis at birth

Autor: Paul Clarke, Martin J. Shearer, David J. Card, Amy Nichols, Vennila Ponnusamy, Ajit Mahaveer, Kieran Voong, Karen Dockery, Nicky Holland, Shaveta Mulla, Lindsay J. Hall, Cecile Maassen, Petra Lux, Leon J. Schurgers, Dominic J. Harrington

Publikováno v: Journal of Thrombosis and Haemostasis, 20(12), 2773-2785. Wiley

BACKGROUND: There is near-global consensus that all newborns be given parenteral vitamin K1 (VK1 ) at birth as prophylaxis against VK deficiency bleeding (VKDB). Breastmilk has a low VK content and cases of late VKDB are reported in exclusively breas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88200e66d0a705bd9a10d92f8e588352
https://doi.org/10.1111/jth.15874

Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth

Autor: Benjamin Momo Kadia, Mary Iwaret Otiti, Anouschka S Ramsteijn, Doudou Sow, Babacar Faye, Claire Heffernan, Lindsay J Hall, Joanne P Webster, Alan W Walker, Stephen Allen

Publikováno v: Nutrition Reviews.

In children exposed to poor hygiene and sanitation, invasion of the gut by pathogenic microbes can result in a subclinical enteropathy termed “environmental enteric dysfunction” (EED) that contributes to undernutrition, growth faltering, and impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7409dbea4e8c8253938c49477da3363b
https://doi.org/10.1093/nutrit/nuad050

Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Autor: Henrik M. Roager, Catherine Stanton, Lindsay J. Hall

Publikováno v: Roager, H M, Stanton, C & Hall, L J 2023, ' Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life ', Gut Microbes, vol. 15, no. 1, 2192151 . https://doi.org/10.1080/19490976.2023.2192151

The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8faa5dcff3d75af9e635b6d6fb4da3e
https://doi.org/10.1080/19490976.2023.2192151