Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lindsay Fawcett"'
Autor:
Anke Bill, Elizabeth M Rosethorne, Toby C Kent, Lindsay Fawcett, Lynn Burchell, Michiel T van Diepen, Anthony Marelli, Sergey Batalov, Loren Miraglia, Anthony P Orth, Nicole A Renaud, Steven J Charlton, Martin Gosling, L Alex Gaither, Paul J Groot-Kormelink
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97973 (2014)
The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numero
Externí odkaz:
https://doaj.org/article/80aa82d5e7004c4f828cf2a96b6d0895
Autor:
Stephen C. Phillips, T Webb, Lindsay Fawcett, Gillian Burgess, Rhona W Baxendale, Christopher Peter Wayman, C Lunny
Publikováno v:
International Journal of Impotence Research. 17:216-223
Fertilization is well correlated with sperm concentration, rate of forward motility, and percentage of live, uncapacitated ejaculated spermatozoa, which is regulated in part by cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46639dad4ca6a2a5094ab906126fc9a
https://doi.org/10.1038/sj.ijir.3901307
https://doi.org/10.1038/sj.ijir.3901307
Autor:
Michiel T. van Diepen, Paul J. Groot-Kormelink, Lynn Burchell, Anthony Marelli, L. Alex Gaither, Anke Bill, Anthony P. Orth, Steven J. Charlton, Elizabeth M. Rosethorne, Sergey Batalov, Loren Miraglia, Toby C. Kent, Lindsay Fawcett, Nicole A. Renaud, Martin Gosling
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e97973 (2014)
PLoS ONE, Vol 9, Iss 6, p e97973 (2014)
The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3131fc793b11e7b0dcb9bf6fa01d07
http://europepmc.org/articles/PMC4041722
http://europepmc.org/articles/PMC4041722
Autor:
Brian D. Hudson, Stuart A. Nicklin, Gianluigi Caltabiano, Laura Jenkins, Lindsay Fawcett, Jennifer E. McCallum, Amanda E. Mackenzie, Toby C. Kent, Rachel Markwick, Graeme Milligan, Steven J. Charlton
Publikováno v:
Molecular pharmacology. 85(1)
Lack of high potency agonists has restricted analysis of the G protein–coupled receptor GPR35. Moreover, marked variation in potency and/or affinity of current ligands between human and rodent orthologs of GPR35 has limited their productive use in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c07f6db3b425aa0ddb5e7ecc7d30621
https://pubmed.ncbi.nlm.nih.gov/24113750
https://pubmed.ncbi.nlm.nih.gov/24113750
Autor:
Steven J. Charlton, Toby C. Kent, Emilie Renard, Mark R Dowling, David A. Sykes, Juliet Leighton-Davies, Lindsay Fawcett, Alexandre Trifilieff
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 343(2)
Studies under nonphysiological conditions suggest that long receptor residency time is responsible for the 24-h duration of action of the long-acting muscarinic antagonist (LAMA) tiotropium. Our aim was to determine how clinically relevant dissociati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ec6053f8fa01c975cb25a123685b1f
https://pubmed.ncbi.nlm.nih.gov/22854200
https://pubmed.ncbi.nlm.nih.gov/22854200
Autor:
Scott H. Soderling, Stephen Phillips, Lindsay Fawcett, Peter Stacey, Joanna Hetman, Ian Harrow, Collette McGrouther, Joseph A. Beavo, Rhona W. Baxendale
We report here the cloning, expression, and characterization of human PDE11A1, a member of a distinct cyclic nucleotide phosphodiesterase (PDE) family. PDE11A exhibits ≤50% amino acid identity with the catalytic domains of all other PDEs, being mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fee3c3c1829775a5dda9e02e1a9e13
https://europepmc.org/articles/PMC16303/
https://europepmc.org/articles/PMC16303/
Publikováno v:
European Urology Supplements. 1:63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7bfae75edc6f643423b8309ab698d7
https://doi.org/10.1016/s1569-9056(02)80240-8
https://doi.org/10.1016/s1569-9056(02)80240-8
Publikováno v:
BMC Immunology, Vol 13, Iss 1, p 57 (2012)
BMC Immunology
BMC Immunology
Background Alveolar macrophages are one of the first lines of defence against invading pathogens and play a central role in modulating both the innate and acquired immune systems. By responding to endogenous stimuli within the lung, alveolar macropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca14926e46445c76726cbea5a3b44cb