Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lindsay Farrer"'
Autor:
Yuk Yee Leung, Adam C. Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Amanda B. Kuzma, Wan-Ping Lee, Laura Cantwell, Heather Nicaretta, Alzheimer’s Disease Sequencing Project, Jonathan Haines, Lindsay Farrer, Sudha Seshadri, Zoran Brkanac, Carlos Cruchaga, Margaret Pericak-Vance, Richard P. Mayeux, William S. Bush, Anita Destefano, Eden Martin, Gerard D. Schellenberg, Li-San Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a bioinformatics strategy for joint-calling 20,504 WES samples collected across nine studies and sequenced
Externí odkaz:
https://doaj.org/article/378dd02a30dd4635913bd42d5ec182d0
Autor:
Diane Xue, William S. Bush, Alan E. Renton, Edoardo A. Marcora, Joshua C. Bis, Brian W. Kunkle, The Alzheimer's Disease Sequencing Project, Eric Boerwinkle, Anita L. DeStefano, Lindsay Farrer, Alison Goate, Richard Mayeux, Margaret Pericak‐Vance, Gerard Schellenberg, Sudha Seshadri, Ellen Wijsman, Jonathan L. Haines, Elizabeth E. Blue
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction Genes implicated by genome‐wide association studies and family‐based studies of Alzheimer's disease (AD) are largely discordant. We hypothesized that genes identified by sequencing studies like the Alzheimer's Disease Sequen
Externí odkaz:
https://doaj.org/article/a9dabf1346b743b9b46a5c25aef8dddc
Autor:
Jiayi Wu Cox, Devanshi Patel, Jaeyoon Chung, Congcong Zhu, Samantha Lent, Virginia Fisher, Achilleas Pitsillides, Lindsay Farrer, Xiaoling Zhang
Publikováno v:
BMC Proceedings, Vol 12, Iss S9, Pp 241-247 (2018)
Abstract Background The study of DNA methylation quantitative trait loci (meQTLs) helps dissect regulatory mechanisms underlying genetic associations of human diseases. In this study, we conducted the first genome-wide examination of genetic drivers
Externí odkaz:
https://doaj.org/article/db9be01f02584ab787322d22d13607bb
Autor:
Kathryn Atherton, Xudong Han, Jaeyoon Chung, Jonathan D. Cherry, Zachary Baucom, Nicole Saltiel, Evan Nair, Bobak Abdolmohammadi, Madeline Uretsky, Mohammed Muzamil Khan, Conor Shea, Shruti Durape, Brett M. Martin, Joseph N. Palmisano, Kurt Farrell, Christopher J. Nowinski, Victor E. Alvarez, Brigid Dwyer, Daniel H. Daneshvar, Douglas I. Katz, Lee E. Goldstein, Robert C. Cantu, Neil W. Kowall, Michael L. Alosco, Bertrand R. Huber, Yorghos Tripodis, John F. Crary, Lindsay Farrer, Robert A. Stern, Thor D. Stein, Ann C. McKee, Jesse Mez
Publikováno v:
JAMA Neurol
ImportanceRepetitive head impact (RHI) exposure is the chief risk factor for chronic traumatic encephalopathy (CTE). However, the occurrence and severity of CTE varies widely among those with similar RHI exposure. Limited evidence suggests that the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15e4d76f50ea5b321d8e49d6aacb144
https://pubmed.ncbi.nlm.nih.gov/36251311
https://pubmed.ncbi.nlm.nih.gov/36251311
Autor:
Badri N, Vardarajan, Dolly, Reyes-Dumeyer, Angel L, Piriz, Rafael A, Lantigua, Martin, Medrano, Diones, Rivera, Ivonne Z, Jiménez-Velázquez, Eden, Martin, Margaret A, Pericak-Vance, William, Bush, Lindsay, Farrer, Jonathan L, Haines, Li-San, Wang, Yuk Yee, Leung, Gerard, Schellenberg, Walter, Kukull, Philip, De Jager, David A, Bennett, Julie A, Schneider, Richard, Mayeux
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's Association. 18(12)
Progranulin (GRN) mutations occur in frontotemporal lobar degeneration (FTLD) and in Alzheimer's disease (AD), often with TDP-43 pathology.We determined the frequency of rs5848 and rare, pathogenic GRN mutations in two autopsy and one family cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66602b44148e6db9915cde774896e13d
https://pubmed.ncbi.nlm.nih.gov/35258170
https://pubmed.ncbi.nlm.nih.gov/35258170
Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease
Autor:
Priyanka Baloni, Cory C. Funk, Jingwen Yan, James T. Yurkovich, Alexandra Kueider-Paisley, Kwangsik Nho, Almut Heinken, Wei Jia, Siamak Mahmoudiandehkordi, Gregory Louie, Andrew J. Saykin, Matthias Arnold, Gabi Kastenmüller, William J. Griffiths, Ines Thiele, Rima Kaddurah-Daouk, Nathan D. Price, P. Murali Doraiswamy, Colette Blach, Arthur Moseley, J. Will Thompson, Siamak Mahmoudiandehkhordi, Kathleen Welsh-Balmer, Brenda Plassman, Andrew Saykin, Sudeepa Bhattacharyya, Xianlin Han, Rebecca Baillie, Oliver Fiehn, Dinesh Barupal, Peter Meikle, Sarkis Mazmanian, Mitchel Kling, Leslie Shaw, John Trojanowski, Jon Toledo, Cornelia van Duijin, Thomas Hankemier, Nathan Price, Cory Funk, David Wishart, Roberta Brinton, Rui Chang, Lindsay Farrer, Rhoda Au, Wendy Qiu, Peter Würtz, Lara Mangravite, Jan Krumsiek, John Newman, Bin Zhang, Herman Moreno
Publikováno v:
Cell Reports Medicine
Summary Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes and identify genes in the al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09358fa89705a4272c66ea544a9e09f0
https://doi.org/10.1016/j.xcrm.2020.100138
https://doi.org/10.1016/j.xcrm.2020.100138
Publikováno v:
Addiction biology. 21(4)
Although alcohol dependence (AD) is approximately 50% heritable, little is known about how specific genetic loci affect AD risk. In a genome-wide association study (GWAS), we identified highly significant associations between two population-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::224f07b80172d4f02e58b41d39110326
https://pubmed.ncbi.nlm.nih.gov/25828809
https://pubmed.ncbi.nlm.nih.gov/25828809
Publikováno v:
JAMA: The Journal of the American Medical Association. 278:1349-1356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ed8760b496aa81f17c263cdad0efa3
https://doi.org/10.1001/jama.278.16.1349
https://doi.org/10.1001/jama.278.16.1349
Autor:
Lori Chibnik, Lei Yu, Towfique Raj, Jishu Xu, Nikolaos Patsopoulos, Brendan Keenan, Richard Sherva, Sue Leurgans, Deborah Blacker, Robert Wilson, Eric Reiman, Matthew Huentelman, The Alzheimer's Disease Genetics Consortium, Robert Green, Lindsay Farrer, Paul Crane, David Weir, Richard Mayeux, Richard Lipton, Gerard Schellenberg, Denis Evans, Philip De Jager, David Bennett
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5ecc7b1909d22e6e2295eb6c181e7f0
https://doi.org/10.1016/j.jalz.2013.05.1097
https://doi.org/10.1016/j.jalz.2013.05.1097
Autor:
Ryozo Kuwano, Akinori Miyashita, Asako Koike, Gyungah Jun, Li‐San Wang, Satoshi Takahashi, Jong‐Won Kim, Peter St. George‐Hyslop, Richard Mayeux, Jonathan Haines, Margaret Pericak‐Vance, Makiko Yoshida, Nao Nishida, Katsusi Tokunaga, Ken Yamamoto, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Gerard Schellenberg, Lindsay Farrer
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::912c9e97d0b463f61eb8666b467eef9c
https://doi.org/10.1016/j.jalz.2013.04.369
https://doi.org/10.1016/j.jalz.2013.04.369