Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lindsay C, Spender"'
Autor:
Lauren S. Strathearn, Lindsay C. Spender, Christina Schoenherr, Susan Mason, Ruaridh Edwards, Karen Blyth, Gareth J. Inman
Publikováno v:
Cells, Vol 13, Iss 18, p 1530 (2024)
Transforming Growth Factor-β (TGF-β) can have both tumour-promoting and tumour-suppressing activity in breast cancer. Elucidating the key downstream mediators of pro-tumorigenic TGF-β signalling in this context could potentially give rise to new t
Externí odkaz:
https://doaj.org/article/1dc318d17fc54d8585feee5e55334e8b
Autor:
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated w
Externí odkaz:
https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
Autor:
Investigators, Mark A. Baxter, Lindsay C. Spender, Shaun Walsh, Susan Bray, Gemma Skinner, Sharon King, Peter S. Hall, Matthew J. Seymour, Russell D. Petty, on behalf of the GO2 Investigators on behalf of the GO2
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2591
Gastroesophageal adenocarcinoma is a disease of older adults that is associated with a very poor prognosis. It is less common and has better outcomes in females. The reason for this is unknown but may relate to signalling via the main oestrogen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::18b722d2bb2e6ec8157c82ab45438727
Autor:
Gareth J. Inman, Lindsay C. Spender
Burkitt's lymphoma (BL), driven by translocation and overexpression of the c-MYC gene, is an aggressive, highly proliferative lymphoma, and novel therapeutic strategies are required to overcome drug resistance following conventional treatments. The i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bee2f951c5c41f23a637d706743511
https://doi.org/10.1158/1541-7786.c.6541426.v1
https://doi.org/10.1158/1541-7786.c.6541426.v1
Autor:
Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous
Externí odkaz:
https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a
Autor:
Pranavi Challapalli, Z. Miedzybrodzka, Madusha Meemanage, Diane Collinson, Julie Turbitt, Graeme I. Murray, Lindsay C. Spender, Mark Baxter, Russell D. Petty, Joanna Iannetta, Caroline Clark, Shaun V. Walsh
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Oesophageal squamous cell carcinoma (ESCC) has a poor prognosis. Advanced tumours are treated with fluoropyrimidine/platinum chemotherapy followed by irinotecan or taxane monotherapy, but resistance is common and new treatments are needed. Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6a352490840c58f42ba21e281da7dc
https://doi.org/10.1007/s00280-020-04187-w
https://doi.org/10.1007/s00280-020-04187-w
Autor:
D. S. Hill, Marco Corazzari, M Gagliardi, D. Tang, Mauro Piacentini, M.E. Anagnostou, A. McConnell, Gareth J. Inman, Penny E. Lovat, M Elias, A. Greenwood, T. Ewen, Jane L. Armstrong, Lindsay C. Spender, Paola Giglio, Gian Maria Fimia, Robert Ellis, Ioana Cosgarea, A Murray
Publikováno v:
The British journal of dermatology. 186(4)
Background: For patients with early American Joint Committee on Cancer (AJCC)-stage melanoma the combined loss of the autophagy regulatory protein AMBRA1 and the terminal differentiation marker loricrin in the peritumoral epidermis is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affaa512486650dd1367499cb897491a
https://pubmed.ncbi.nlm.nih.gov/35233773
https://pubmed.ncbi.nlm.nih.gov/35233773
Publikováno v:
British Journal of Cancer
Background To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555a576cb3bb70b70bdfbf0027732730
http://europepmc.org/articles/PMC7686478
http://europepmc.org/articles/PMC7686478
Autor:
Madusha Meemanage, Lindsay C Spender, Diane Collinson, Joanna Iannetta, Pranavi Challapalli, Julie Turbitt, Caroline Clark, Mark Baxter, Graeme Murray, Shaun Walsh, Zofia Miedzybrodzka, Russell Petty
BACKGROUND Oesophageal squamous cell carcinoma (ESCC) has high mortality and poor prognosis. Advanced tumours are treated with fluoropyrimidine/platinum chemotherapy (PBC) followed by second-line irinotecan or taxane monotherapy, but resistance is co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee2036b9ea6954abd5b99564871e403
https://doi.org/10.21203/rs.3.rs-31064/v1
https://doi.org/10.21203/rs.3.rs-31064/v1