Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Lindsay C, McDermott"'
1
Identification of diverse lipid‐binding modes in the groove of zinc α 2 glycoprotein reveals its functional versatility
Autor: Stephen J. Perkins, Sharon M. Kelly, Jayesh Gor, Lindsay C. McDermott, Henna Zahid, Kersti Karu, Andy M. Lau
Publikováno v: The FEBS Journal. 289:1876-1896
ZAG is a multifunctional glycoprotein with a class I MHC-like protein fold and an α1-α2 lipid-binding groove. The intrinsic ZAG ligand is unknown. Our previous studies showed that ZAG binds the dansylated C11 fatty acid, DAUDA, differently to the b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24e7b864399385d3fea0833e76e3dd9a
https://doi.org/10.1111/febs.16293
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2
The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy
Autor: Lindsay C. McDermott, Jayesh S. Bhatt, Daniel P. Gale, Stephen J. Perkins, Jayesh Gor, Nilufar Kadkhodayi-Kholghi
Publikováno v: 'Journal of Biological Chemistry ', vol: 295, pages: 16342-16358 (2020)
J Biol Chem
The human complement Factor H–related 5 protein (FHR5) antagonizes the main circulating complement regulator Factor H, resulting in the deregulation of complement activation. FHR5 normally contains nine short complement regulator (SCR) domains, but
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec81c2660e4cdbc1212aa34b130fdd19
https://doi.org/10.1074/jbc.ra120.015132
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4
Identification of diverse lipid-binding modes in the groove of zinc α
Autor: Henna, Zahid, Andy M, Lau, Sharon M, Kelly, Kersti, Karu, Jayesh, Gor, Stephen J, Perkins, Lindsay C, McDermott
Publikováno v: The FEBS journalReferences. 289(7)
ZAG is a multifunctional glycoprotein with a class I MHC-like protein fold and an α1-α2 lipid-binding groove. The intrinsic ZAG ligand is unknown. Our previous studies showed that ZAG binds the dansylated C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b03edff7fce6c69868fd579d0aa5c7c
https://pubmed.ncbi.nlm.nih.gov/34817923
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6
Crystal structure of zinc-α2-glycoprotein in complex with a fatty acid reveals multiple different modes of protein-lipid binding
Autor: Henna Zahid, Alun R. Coker, Andy M. Lau, Lindsay C. McDermott, Stephen J. Perkins, Jayesh Gor
Publikováno v: The Biochemical journal. 476(19)
Human zinc-α2-glycoprotein (ZAG) is a 42 kDa adipokine which regulates body fat mass and is associated with cachexia and obesity. ZAG belongs to the major histocompatibility complex class I protein family and binds long-chain polyunsaturated fatty a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127946710acdb99f0ac04359e25cbcf0
https://pubmed.ncbi.nlm.nih.gov/31506272
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7
Arachidonic acid metabolism in the human placenta: Identification of a putative lipoxygenase
Autor: Ayesha Jadoon, Philip Cunningham, Lindsay C. McDermott
Publikováno v: Placenta. 35:422-424
Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition. We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network whi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bb30a37beb15bf07979c7eb24e7419
https://doi.org/10.1016/j.placenta.2014.03.024
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9
Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites
Autor: Jayesh Gor, Lindsay C. McDermott, Layeque Miah, Alex F. Drake, Henna Zahid, Stephen J. Perkins, Lea Brochard, Tam T. T. Bui, Andy M. Lau, Debolina Hati
Publikováno v: Zahid, H, Miah, L, Lau, A M, Brochard, L, Hati, D, Bui, T T T, Drake, A F, Gor, J, Perkins, S J & McDermott, L C 2016, ' Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites ', Biochemical Journal, vol. 473, no. 1, pp. 43-54 . https://doi.org/10.1042/BJ20150836
Zinc α2 glycoprotein (ZAG) is an adipokine with a class I MHC protein fold and is associated with obesity and diabetes. Although its intrinsic ligand remains unknown, ZAG binds the dansylated C11 fatty acid 11-(dansylamino)undecanoic acid (DAUDA) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7bf4d6a898b58a03d82e37d3b77888
https://kclpure.kcl.ac.uk/ws/files/46883935/BJ20150836full_Zinc_protein_2015.pdf
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10
Zn-α2-glycoprotein, an MHC Class I-Related Glycoprotein Regulator of Adipose Tissues: Modification or Abrogation of Ligand Binding by Site-Directed Mutagenesis
Autor: Anthony P. West, Lindsay C. McDermott, Malcolm W. Kennedy, June A. Freel, Pamela J. Bjorkman
Publikováno v: Biochemistry. 45:2035-2041
Zn-alpha(2)-glycoprotein (ZAG) is a soluble lipid-mobilizing factor associated with cancer cachexia and is a novel adipokine. Its X-ray crystal structure reveals a poly(ethylene glycol) molecule, presumably substituting for a higher affinity natural
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc41e542675a1446b6a09d9dd4ce70b
https://doi.org/10.1021/bi051881v
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