Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.

Autor: Jian Liu, David A Copland, Shintaro Horie, Wei-Kang Wu, Mei Chen, Yunhe Xu, B Paul Morgan, Matthias Mack, Heping Xu, Lindsay B Nicholson, Andrew D Dick

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72935 (2013)

Whilst data recognise both myeloid cell accumulation during choroidal neovascularisation (CNV) as well as complement activation, none of the data has presented a clear explanation for the angiogenic drive that promotes pathological angiogenesis. One

Externí odkaz: https://doaj.org/article/03d5e60df6cb4adb9b7880edb582c0c5

Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation

Autor: Oliver H. Bell, David A. Copland, Amy Ward, Lindsay B. Nicholson, Clemens A. K. Lange, Colin J. Chu, Andrew D. Dick

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus to charac

Externí odkaz: https://doaj.org/article/00003238d97e4deeb4055af0aef3239a

Emerging roles for IL-6 family cytokines as positive and negative regulators of ectopic lymphoid structures

Autor: David Hill, Gareth W. Jones, Amy Ward, Lindsay B. Nicholson

Publikováno v: Hill, D G, Ward, A, Nicholson, L B & Jones, G W 2021, ' Emerging roles for IL-6 family cytokines as positive and negative regulators of ectopic lymphoid structures ', Cytokine, vol. 146, 155650 . https://doi.org/10.1016/j.cyto.2021.155650

IL-6 family cytokines display broad effects in haematopoietic and non-haematopoietic cells that regulate immune homeostasis, host defence, haematopoiesis, development, reproduction and wound healing. Dysregulation of these activities places this cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efeeacfa3dbc7afd1cd7f3ab3a1aad4b
https://research-information.bris.ac.uk/ws/files/284767917/Revision_Hill_et_al_Cytokine_Review_VSI_IL_6_copy.pdf

Activation of bone marrow adaptive immunity in type 2 diabetes:rescue by co-stimulation modulator Abatacept

Autor: Marianna Santopaolo, Niall Sullivan, Anita Coral Thomas, Valeria Vincenza Alvino, Lindsay B. Nicholson, Yue Gu, Gaia Spinetti, Marinos Kallikourdis, Ashley Blom, Paolo Madeddu

Publikováno v: Santopaolo, M, Sullivan, N, Thomas, A C, Alvino, V V, Nicholson, L B, Gu, Y, Spinetti, G, Kallikourdis, M, Blom, A W & Madeddu, P R 2021, ' Activation of bone marrow adaptive immunity in type 2 diabetes : rescue by co-stimulation modulator Abatacept ', Frontiers in Immunology, vol. 12, 609406 . https://doi.org/10.3389/fimmu.2021.609406
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Background: Chronic low-grade inflammation and alterations in innate and adaptive immunity were reported in Type 2 diabetes (T2D). Here, we investigated the abundance and activation of T cells in the bone marrow (BM) of patients with T2D. We then ver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f951b535114a2a2ae763458938a664
https://research-information.bris.ac.uk/ws/files/270526158/fimmu_12_609406.pdf

Multimodal Retinal Image Registration and Fusion Based on Sparse Regularization via a Generalized Minimax-concave Penalty

Autor: Colin J Chu, Lindsay B. Nicholson, Alin Achim, Oliver Bell, Rencheng Zheng, Xin Tian

Publikováno v: ICASSP

We introduce a novel framework for the fusion of retinal OCT and confocal images of mice with uveitis. Input images are semi-automatically registered and then fused to provide more informative retinal images for analysis by ophthalmologists and clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ce699f472cd2a8f75cb85d454e1825
https://doi.org/10.1109/icassp.2019.8683010