Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lindsay A. Wegiel"'
Experimental Aspects of Measuring the Vial Heat Transfer Coefficient in Pharmaceutical Freeze-Drying
Publikováno v:
AAPS PharmSciTech. 19:1810-1817
One of the current methods for cycle optimization in primary drying to is develop a graphical design space based on quality by design (QbD). In order to construct the design space, the vial heat transfer coefficient (Kv) is needed. This paper investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02297f27c892ade770655d8a11702480
https://doi.org/10.1208/s12249-018-0998-z
https://doi.org/10.1208/s12249-018-0998-z
Publikováno v:
Journal of pharmaceutical sciences. 106(12)
The objective of this research was to study the atypical secondary drying dynamics observed during the freeze-drying of a formulation consisting of mannitol, disaccharide, and sodium chloride, where "bursts" of water vapor release were observed durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d714e2dd0e376a5edfb75fe34934f260
https://pubmed.ncbi.nlm.nih.gov/28867201
https://pubmed.ncbi.nlm.nih.gov/28867201
Publikováno v:
Carbohydrate Polymers. 98:1108-1116
Amorphous solid dispersions (ASD) of curcumin (Cur) in cellulose derivative matrices, hydroxypropylmethylcellulose acetate succinate (HPMCAS), carboxymethylcellulose acetate butyrate (CMCAB), and cellulose acetate adipate propionate (CAAdP) were prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52aeeac968f32bcff9e1823b98e3680
https://doi.org/10.1016/j.carbpol.2013.07.017
https://doi.org/10.1016/j.carbpol.2013.07.017
Publikováno v:
Cellulose. 20:2137-2149
Naringenin (Nar) is an important bioactive flavonoid with poor organic solubility and oral bioavailability. It is highly promising for treatment of conditions including diabetes, hyperlipidemia, and hepatitis C infection. Amorphous solid dispersion (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fddb525bed0ff3fa2407052e821e12a9
https://doi.org/10.1007/s10570-013-9970-y
https://doi.org/10.1007/s10570-013-9970-y
Publikováno v:
Journal of Pharmacy and Pharmacology. 66:244-255
Objectives The development of amorphous solid dispersions is of increasing interest in the delivery of bioactive compounds; however, there is a need for a methodology that enables the rational selection of polymers for solid dispersion formulations w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0ba2585681c1f195acc1c62c74f148
https://doi.org/10.1111/jphp.12079
https://doi.org/10.1111/jphp.12079
Publikováno v:
Cellulose. 20:1249-1260
Resveratrol is a highly biologically active phytoalexin, found in many plant materials that are common elements of the human diet, such as grapes, nuts, and red wine. The therapeutic or disease preventative potential of this natural polyphenolic anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eb0747cc44084a34a50ec8cc1f2bd69
https://doi.org/10.1007/s10570-013-9889-3
https://doi.org/10.1007/s10570-013-9889-3
Publikováno v:
Carbohydrate Polymers. 92:1443-1450
Structurally varied, carboxyl-containing cellulose derivatives were evaluated for their ability to form amorphous solid dispersions (ASD) with ellagic acid (EA), in order to improve the solubility of this high-melting, poorly bioavailable, but highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6e68ed3fb597b39f9163423eff5d48
https://doi.org/10.1016/j.carbpol.2012.10.051
https://doi.org/10.1016/j.carbpol.2012.10.051
Publikováno v:
Carbohydrate Polymers. 92:2033-2040
Amorphous solid dispersions (ASD) of quercetin (Que) in cellulose derivative matrices, carboxymethylcellulose acetate butyrate (CMCAB), hydroxypropylmethylcellulose acetate succinate (HPMCAS), and cellulose acetate adipate propionate (CAAdP) were pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0ee18606fe4cb327dc14a5c2eda08b
https://doi.org/10.1016/j.carbpol.2012.11.073
https://doi.org/10.1016/j.carbpol.2012.11.073
Publikováno v:
Journal of Pharmaceutical Sciences. 102:171-184
The objective of this study was to investigate intermolecular interactions between resveratrol and polymers in amorphous blends and to study the potential correlations between compound-polymer interactions, manufacturability, and stability of the amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658e728a77f9588e04a9da2052fa9e6e
https://doi.org/10.1002/jps.23358
https://doi.org/10.1002/jps.23358
Publikováno v:
Pharmaceutical research. 32(10)
To investigate the phase behavior of resveratrol amorphous solid dispersions upon addition to aqueous media.Polymers with different crystallization inhibitor properties were used to form amorphous solid dispersions of resveratrol. Resveratrol crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abbd493938a9e46fe130769c6280561
https://pubmed.ncbi.nlm.nih.gov/25975588
https://pubmed.ncbi.nlm.nih.gov/25975588