Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lindsay A. Hobson"'
Publikováno v:
ARKIVOC, Vol 2001, Iss 8, Pp 59-69 (2001)
Externí odkaz:
https://doaj.org/article/ae5d8805f04a4287a237f7de4200a494
Autor:
Carla V. Luciani, Lindsay A. Hobson, Batool Ahmed Omer, Kevin D. Seibert, Sushil K. Srivastava, Matt E. Popkin, John Lepore
Publikováno v:
Journal of Pharmaceutical Innovation. 14:1-14
A series of case histories from IQ consortium member companies will be presented to exemplify how the application of the ICH Q11 vision for enhanced Quality by Design (QbD) development of the active pharmaceutical ingredient (API) can lead to differe
Autor:
Phil J. Borman, John Lepore, Sushil K. Srivastava, Nathan D. Ide, John Donaubauer, Steven Tymonko, Matt E. Popkin, Lindsay A. Hobson, Kevin D. Seibert, Timothy Curran, Batool Ahmed Omer, Jeffrey M. Kallemeyn, Looker Adam
Publikováno v:
Journal of Pharmaceutical Innovation. 13:367-372
This paper by IQ consortium member companies will describe how the application of the ICH Q11 vision for enhanced QbD development can lead to flexibility through differentiated outcomes for elements of API manufacture, such as the control strategy an
Autor:
Lindsay T. Hobson, Kenith V. Sobel
Publikováno v:
Psi Chi Journal of Psychological Research. 22:64-71
Autor:
Nathan R. Domagalski, Sha Lou, Michaël D. B. Fenster, Daniel M. Hallow, Lindsay A. Hobson, Srinivas Tummala, Sushil K. Srivastava, Antonio Ramirez
Publikováno v:
Organic Process Research & Development. 20:1781-1791
This manuscript describes the development of a control strategy for impurities in the final intermediate step of the asunaprevir drug substance utilizing the concepts outlined in the International Conference on Harmonisation guidelines (ICH Q8 (R2),
Publikováno v:
Organic Process Research & Development. 16:567-576
This work presents a process modeling-based methodology towards quality by design that was applied throughout the development lifecycle of the ibipinabant API step. By combining mechanistic kinetic modeling with fundamental thermodynamics, the degrad
Autor:
Lindsay A. Hobson, Olav Lyngberg, Brenda Remy, Dong Lin, Shawn Brueggemeier, Alexander J. Marchut
Publikováno v:
Organic Process Research & Development. 12:381-391
Utilizing kinetic process modeling, the conditions for a pharmaceutical guanylation reaction were optimized to promote controlled generation of methanethiol and efficient removal from the off-gas stream via wet scrubbing. Optimization of the kinetic
Autor:
Pingli Liu, James P. Sherbine, Patrick J. Sheeran, Stephen R. Anderson, Benjamin R. P. Stone, Jiang Zhu, Subodh Shrinivas Deshmukh, James J. Haley, Nicholas A. Magnus, Lindsay A. Hobson, William A. Nugent
Publikováno v:
Organic Process Research & Development. 11:985-995
This report describes the large-scale synthesis of 1 that features a Fischer indole strategy to form an advanced intermediate followed by reduction to the indoline to construct the tetracyclic core of the molecule. Resolution using dibenzoyl-d-tartar
Autor:
Eric J. Thomas, Olivier Germay, Christopher J Moore, Nathaniel G. Martin, Lindsay A. Hobson, E. Kate Dorling, Matthew Booth, Anna P. Weston, Sam Donnelly, Devendra Negi, Pilar Castreno, Naresh Kumar, Christopher T. Brain
Publikováno v:
Pure and Applied Chemistry. 78:2015-2028
Allylstannanes with remote heteroatom substituents are transmetallated by tin(IV) halides to give allyltin trihalides which react with aldehydes with useful levels of remote stereocontrol; the use of this chemistry is exemplified by syntheses of seve
Publikováno v:
ChemInform. 45
The asymmetric cyclopropanation of protected glycine derivative (I) gives rise to vinylcyclopropanecarboxylic acid ethyl ester with 77—81% e.e.