Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lindsay A. Beaton-Green"'
Autor:
Leah Nemzow, Thomas Boehringer, Jessica Mayenburg, Lindsay A. Beaton-Green, Ruth C. Wilkins, Helen C. Turner
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/1756833ed6c7463fa71ca108bf3dd431
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8bed8535ff19a5f6ceab85471e55bb
https://doi.org/10.1007/978-1-0716-3020-4_6
https://doi.org/10.1007/978-1-0716-3020-4_6
Publikováno v:
Methods. 112:18-24
Biodosimetry is an important tool for triage in the case of large-scale radiological or nuclear emergencies, but traditional microscope-based methods can be tedious and prone to scorer fatigue. While the dicentric chromosome assay (DCA) has been adap
Publikováno v:
The Micronucleus Assay in Toxicology ISBN: 9781788011341
Micronucleus (MN) assays are used as a measure of cellular damage, and are often preferred over other chromosomal aberration assays since they possess similar statistical robustness for detection of genotoxins and require less technical expertise, ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e4570fad21707a1b6a2af5c066b6e5
https://doi.org/10.1039/9781788013604-00305
https://doi.org/10.1039/9781788013604-00305
Autor:
Matthew A. Rodrigues, Jay R. Perrier, Guy Garty, Helen Turner, Qi Wang, Mikhail Repin, Sergey Pampou, Ruth C. Wilkins, David J. Brenner, Lindsay A. Beaton-Green
The cytokinesis-block micronucleus (CBMN) assay has become a fully-validated and standardized method for radiation biodosimetry. The assay is typically performed using microscopy, which is labor intensive, time consuming and impractical after a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8408a3a566ed8b8a158ed3b2ee4e119
https://europepmc.org/articles/PMC6483078/
https://europepmc.org/articles/PMC6483078/
Publikováno v:
Radiation Protection Dosimetry. 172:223-229
In cases of overexposure to ionizing radiation, the cytokinesis-block micronucleus (CBMN) assay can be performed in order to estimate the dose of radiation to an exposed individual. However, in the event of a large-scale radiation accident with many
Publikováno v:
Cytometry Part A. 89:653-662
The cytokinesis-block micronucleus (CBMN) assay is a well-established technique that can be employed in triage radiation biodosimetry to estimate whole body doses of radiation to potentially exposed individuals through quantitation of the frequency o
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis. 836
The lymphocyte Cytokinesis-Block Micronucleus (CBMN) assay was originally developed for the measurement of micronuclei (MN) exclusively in binucleated (BN) cells, which represent the population of cells that can express MN because they completed nucl
Autor:
Lindsay A. Beaton-Green, B.C. Kutzner, C. Ferrarotto, Ruth C. Wilkins, Gordon K. Livingston, Leonora Marro, Sylvie Lachapelle, Farrah Flegal, Vinita Chauhan, Hillary Boulay Greene
Publikováno v:
International Journal of Radiation Biology
Purpose: To evaluate the importance of annual intercomparisons for maintaining the capacity and capabilities of a well-established biodosimetry network in conjunction with assessing efficient and effective analysis methods for emergency response. Mat
Publikováno v:
Genome Integrity
Biodosimetry methods, including the dicentric chromosome assay, the cytokinesis-block micronucleus assay and the γH2AX marker of DNA damage are used to determine the dose of ionizing radiation. These techniques are particularly useful when physical