Prevalence of frailty in patients with polymyalgia rheumatica and association with health-related quality of life, cognition and sarcopenia

Autor: Sebastian E Sattui, Deanna Jannat-Khah, Lindsay Lally, Sarah B Lieber, Lisa A Mandl, Robert F Spiera

Publikováno v: Rheumatology (Oxford)

Objective To describe the prevalence of frailty in a single-centre cohort of patients with PMR and describe its association with health-related quality of life (HRQoL), cognition and sarcopenia. Methods This was a cross-sectional study of patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a743ae456f14d48fc2004bfe29e7671b
https://doi.org/10.1093/rheumatology/keac050

Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

Autor: Sharon A. Chung, Gökhan Keser, Ayten Yazici, Zeynep Ozbalkan, R. Maughan, Servet Akar, Fatma Alibaz-Oner, Nurullah Akkoc, Kathleen McKinnon-Maksimowicz, Patrick Coit, Güher Saruhan-Direskeneli, Chris Wallace, Omer Karadag, Muge Bicakcigil, Antoine G. Sreih, Ahmet Mesut Onat, Paul A. Monach, Ying Sun, Kenan Aksu, Carol A. Langford, Mehmet Akif Ozturk, Izzet Fresko, Eren Erken, Lindsay Lally, Lindsy J. Forbess, Christian Pagnoux, Ayse Cefle, Ediz Dalkilic, Timothy J. Vyse, Veli Cobankara, Peter C. Grayson, Guillermo Reales, David Cuthbertson, Philip Seo, Gozde Yildirim Cetin, Curry L. Koening, Sibel P. Yentür, Yaşar Karaaslan, Lourdes Ortiz-Fernández, Nilufer Alpay-Kanitez, Bunyamin Kisacik, Xiufang Kong, Sibel Zehra Aydin, Enrico Tombetti, Sule Yavuz, Lindi Jiang, Fatos Onen, Allan P. Kiprianos, Nurşen Düzgün, Nader Khalidi, Justin C. Mason, Huiyong Chen, Aşkın Ateş, Angelo A. Manfredi, Murat Inanc, Sevil Kamali, Sema Kaymaz-Tahra, Steven R. Ytterberg, Timuçin Kaşifoğlu, Emire Seyahi, Elena Baldissera, Deborah S. Cunninghame-Graham, Sedat Kiraz, Jason M. Springer, Peter A. Merkel, Haner Direskeneli, Jonathan D. Wren, Kenneth J. Warrington, Carol A. McAlear, Amr H. Sawalha, Huseyin T. E. Ozer

Publikováno v: Am J Hum Genet

Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa13832c2b14faa262d03689dbb58d8b
https://doi.org/10.1016/j.ajhg.2020.11.014

Modification of immunomodulatory medications by rheumatology patients during the peak of the COVID-19 pandemic in New York City

Autor: Medha, Barbhaiya, Marianna B, Frey, Jonah, Levine, Gregory, Vitone, Lindsay, Lally, Michael D, Lockshin, Vivian, Bykerk, Candace H, Feldman, Lisa A, Mandl

Publikováno v: Clinical rheumatology. 41(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80805ac548781248dde8afae32ed7f4d
https://pubmed.ncbi.nlm.nih.gov/35596096

Management of difficult polymyalgia rheumatica and giant cell arteritis: Updates for clinical practice

Autor: Lindsay Lally, Robert Spiera

Publikováno v: Best Practice & Research Clinical Rheumatology. 32:803-812

Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) represent a family of systemic inflammatory diseases occurring in adults aged 50 years and above. Clinical presentation of PMR/GCA can be variable, making diagnosis at times challenging. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b65ef325c6e235920999ce14dab250
https://doi.org/10.1016/j.berh.2019.04.006

Brief Report: A Prospective Open-Label Phase IIa Trial of Tocilizumab in the Treatment of Polymyalgia Rheumatica

Autor: Lindsy J. Forbess, Robert Spiera, Christopher Hatzis, Lindsay Lally

Publikováno v: Arthritis & Rheumatology. 68:2550-2554

Objective Interleukin-6 (IL-6) is a pivotal cytokine in the pathogenesis of polymyalgia rheumatica (PMR), yet the efficacy of IL-6 blockade with tocilizumab (TCZ) for the treatment of PMR is unknown. The aim of this study was to assess the efficacy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35e70ee5c4ca77d08b085984bea1e9f7
https://doi.org/10.1002/art.39740