A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Autor: Birthe Meineke, Johannes Heimgärtner, Alexander J. Craig, Michael Landreh, Lindon W. K. Moodie, Simon J. Elsässer

Publikováno v: Frontiers in Chemistry, Vol 9 (2021)

Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been i

Externí odkaz: https://doaj.org/article/80dfbc6fdcfb4fc3aa01db18bc5f6838

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

Autor: Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O. Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J. Craig, Yoseph Atilaw, Anja Sandström, Lindon W. K. Moodie, Åke Lundkvist, Martijn J. van Hemert, Johan Neyts, Johan Lennerstrand, Jan Kihlberg, Kristian Sandberg, U. Helena Danielson, Jens Carlsson

Publikováno v: Journal of the American Chemical Society, 144(7), 2905-2920. AMER CHEMICAL SOC

Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946c3c3e10aa0c690988b970c049d161
http://hdl.handle.net/1887/3479854

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from

Autor: Neda, Safa, Tomaž, Trobec, Darren C, Holland, Blazej, Slazak, Erik, Jacobsson, Jeffrey A, Hawkes, Robert, Frangež, Kristina, Sepčić, Ulf, Göransson, Lindon W K, Moodie, Luke P, Robertson

Publikováno v: Journal of Natural Products

During a research program to identify new cholinesterase inhibitors of natural origin, two new 7,8-didehydroprotoberberine alkaloids (1 and 2) and nine known compounds (3–11) were isolated from the capsules of the common ornamental poppy, Papaver s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26e5bb480ffd24cb8056563c905f9af5
https://pubmed.ncbi.nlm.nih.gov/34910498

Natural cholinesterase inhibitors from marine organisms

Autor: Robert Frangež, Johan Svenson, Kristina Sepčić, Tom Turk, Lindon W. K. Moodie

Publikováno v: Natural Product Reports. 36:1053-1092

Covering: Published between 1974 up to 2018 Inhibition of cholinesterases is a common approach for the management of several disease states. Most notably, cholinesterase inhibitors are used to alleviate the symptoms of neurological disorders like dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71bf5003a5fcfa03e21dd0177fd075f
https://doi.org/10.1039/c9np00010k

Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants

Autor: Karine Réhel, Lindon W. K. Moodie, Johan Svenson, Jannie Staffansson, Christophe Labriere, Hugo Denardou, Gunnar Cervin, Jørn H. Hansen, Henrik Pavia, Claire Hellio, Vijayaragavan Elumalai, Tiffany Le Norcy

Publikováno v: Journal of Natural Products
Journal of Natural Products, 2020, Early view, ⟨10.1021/acs.jnatprod.0c00881⟩
Journal Of Natural Products (0163-3864) (American Chemical Society (ACS)), 2020-11, Vol. 83, N. 11, P. 3413-3423

Stationary and slow-moving marine organisms regularly employ a natural product chemical defense to prevent being colonized by marine micro- and macroorganisms. While these natural antifoulants can be structurally diverse, they often display highly co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84a9d79b9aa15a3d399443e3373d764
https://pubmed.ncbi.nlm.nih.gov/33054188