Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

Autor: Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, Amanda Harvey, Catherine Wastella, Hafsa Ahmad, Erin Ross, Adona Pjetergjoka, Sachin Prasad, Robert Barsotti, Lindon H. Young, Qian Chen

Publikováno v: BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-16 (2021)

Abstract Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection a

Externí odkaz: https://doaj.org/article/3f2b1c26fd21402fa30c95fbbc3d7ea3

Abstract P509: Novel Protein Kinase C Epsilon Inhibitor Attenuates Uncoupled Endothelial Nitric Oxide Synthase And Vascular Endothelial Dysfunction

Autor: Lindon H. Young, John Ringe, Brogan Galbreath, Ian T. Madison, Alexandra Lopez, Arjun Nair, Qian Chen, Tameka Dean

Publikováno v: Circulation Research. 129

Endothelial nitric oxide synthase (eNOS) uncoupling reduces nitric oxide (NO) production when tetrahydrobiopterin (BH 4 ) is oxidized to dihydrobiopterin (BH 2 ), resulting in endothelial dysfunction and leukocyte adherence. Renovascular damage follo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c0521026c9c86dedc1102c9bdadb483
https://doi.org/10.1161/res.129.suppl_1.p509

Apocynin Exerts Dose-Dependent Cardioprotective Effects by Attenuating Reactive Oxygen Species in Ischemia/Reperfusion: A Recent Study

Autor: Harsh Patel, Lindon H. Young, Issachar Devine, Robert Barsotti, Tarah Kuhn, Kyle D. Bartol, Tsion Habtamu, C. Woodworth Parker, Regina Ondrasik, Brendan Casey, William Chau, Qian Chen

Ischemia/reperfusion results in cardiac contractile dysfunction and cell death partly due to increased reactive oxygen species and decreased endothelial-derived nitric oxide bioavailability. Ischemia/reperfusion injury is initiated in part by endothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a065afa6876a4b9dab2925ed44ae028a
https://doi.org/10.9734/bpi/nfmmr/v7/8739d

Naltrindole Exhibits Robust Cardioprotection in Myocardial Ischemia Reperfusion Injury

Autor: Lindon H. Young, Michael Bamimore, Robert Barsotti, Kayla Harrell, Tameka Dean, Arjun Nair, Alexis Verwoert, Qian Chen

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ba35970c91d9e6ccd97929fb22ec4d5
https://doi.org/10.1096/fasebj.2021.35.s1.04354

State of the World’s Plants and Fungi

Autor: Antonelli, A., Smith, R. J., Fry, C., Simmonds, Monique S. J., Kersey, Paul J., Pritchard, H. W., Abbo, M. S., Acedo, C., Adams, J., Ainsworth A.M., Allkin B., Annecke W, Bachman S P, Bacon, K., Bárrios, S., Barstow, C., Battison, A., Bell, E., Bensusan, K., Bidartondo, M. I., Blackhall-Miles, R. J., Borrell, J. S., Brearley, F. Q., Breman, E., Brewer, R. F. A., Brodie, J., Cámara-Leret, R., Campostrini Forzza, R., Cannon, P., Carine, M., Carretero, J., Cavagnaro, T. R., E Cazar, M., Chapman, T., Cheek, M., Clubbe, C., Cockel, C., Collemare, J., Cooper, A., Copeland, A. I., Corcoran, M., Couch, C., Cowell, C., Crous, P., Da Silva, M., Dalle, G., Das, D., David, J. C., Davies, L., Davies, N., Canha, M. N., Lirio, E. J., Demissew, S., Diazgranados, M., Dickie, J., Dines, T., Douglas, B., Dröge, G., Dulloo, M. E., Fang, R., Farlow, A., Farrar, K., Fay, M. F., Felix, J., Forest, F., Forrest, L. L., Fulcher, T., Gafforov, Y., Gardiner, L. M., Gâteblé, G., Gaya, E., Benoit Geslin, Gonçalves, S. C., Gore, C. J. N., Govaerts, R., Gowda, B., Grace, O. M., Grall, A., Haelewaters, D., Halley, J. M., Hamilton, M. A., Hazra, A., Heller, T., Hollingsworth, P. M., Holstein, N., Howes, M. -J R., Hughes, M., Hunter, D., Hutchinson, N., Hyde, K., Iganci, J., Jones, M., Kelly, L. J., Kirk, P., Koch, H., Krisai-Greilhuber, I., Lall, N., Langat, M. K., Leaman, D. J., Leão, T. C., Lee, M. A., Leitch, I. J., Leon, C., Lettice, E., Lewis, G. P., Li, L., Lindon, H., Liu, J. S., Liu, U., Llewellyn, T., Looney, B., Lovett, J. C., Łukasz Łuczaj, Lulekal, E., Maggassouba, S., Valéry Malécot, Martin, C., Masera, O. R., Mattana, E., Maxted, N., Mba, C., Mcginn, K. J., Metheringham, C., Miles, S., Miller, J., Milliken, W., Moat, J., Moore, P. G. P., Morim, M. P., Mueller, G. M., Muminjanov, H., Negrão, R., Nic Lughadha, E., Nicolson, N., Niskanen, T., Nono Womdim, R., Noorani, A., Obreza, M., O’donnell, K., O’hanlon, R., M Onana, J., Ondo, I., Padulosi, S., Paton, A., Pearce, T., Pérez Escobar, O. A., Pieroni, A., Pironon, S., Prescott, T. A. K., Qi, Y. D., Qin, H., Quave, C. L., Rajaovelona, L., Razanajatovo, H., Reich, P. B., Rianawati, E., Rich, T. C. G., Richards, S. L., Rivers, M. C., Ross, A., Rumsey, F., Ryan, M., Ryan, P., Sagala, S., Sanchez, M. D., Sharrock, S., Shrestha, K. K., Sim, J., Sirakaya, A., Sjöman, H., Smidt, E. C., Smith, D., Smith, P., Smith, S. R., Sofo, A., Spence, N., Stanworth, A., Stara, K., Stevenson, P. C., Stroh, P., Suz, L. M., Tambam, B. B., Tatsis, E. C., Taylor, I., Thiers, B., Thormann, I., Trivedi, C., Twilley, D., Twyford, A. D., Ulian, T., Utteridge, T., Vaglica, V., Vásquez-Londoño, C., Victor, J., Viruel, J., Walker, B. E., Walker, K., Walsh, A., Way, M., Wilbraham, J., Wilkin, P., Wilkinson, T., Williams, C., Winterton, D., Wong, K. M., Woodfield-Pascoe, N., Woodman, J., Wyatt, L., Wynberg, R., Zhang, B. G.

Publikováno v: [Research Report] Royal Botanic Gardens (Kew); Sfumato Foundation. 2020
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bf749f2c8d9e84aec8b5e281e330e80a
https://hal.science/hal-02957519