Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Lindi M Wahl"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008482 (2020)
Integrated into their bacterial hosts' genomes, prophage sequences exhibit a wide diversity of length and gene content, from highly degraded cryptic sequences to intact, functional prophages that retain a full complement of lytic-function genes. We a
Externí odkaz:
https://doaj.org/article/0ff286b88d364e118e008b05f455c8f1
Autor:
Hélène Chabas, Sébastien Lion, Antoine Nicot, Sean Meaden, Stineke van Houte, Sylvain Moineau, Lindi M Wahl, Edze R Westra, Sylvain Gandon
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006738 (2018)
The emergence and re-emergence of pathogens remains a major public health concern. Unfortunately, when and where pathogens will (re-)emerge is notoriously difficult to predict, as the erratic nature of those events is reinforced by the stochastic nat
Externí odkaz:
https://doaj.org/article/54a86ab65d064ce1a8cf60aa3525630f
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110237 (2014)
We propose a model that combines the dynamics of the spread of disease within a bee colony with the underlying demographic dynamics of the colony to determine the ultimate fate of the colony under different scenarios. The model suggests that key fact
Externí odkaz:
https://doaj.org/article/5baa53ff93784d4a9eceb0797c0ef2cb
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35161 (2012)
Baiyangdian (BYD) virus is a recently-identified mosquito-borne flavivirus that causes severe disease in ducks, with extremely rapid transmission, up to 15% mortality within 10 days and 90% reduction in egg production on duck farms within 5 days of i
Externí odkaz:
https://doaj.org/article/926419d5e1be40e8bb2cdb1a23681042
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11082 (2010)
BACKGROUND: There is currently no way to verify the quality of a multiple sequence alignment that is independent of the assumptions used to build it. Sequence alignments are typically evaluated by a number of established criteria: sequence conservati
Externí odkaz:
https://doaj.org/article/95f97a3c895c47f5b895f7a3de6ea6d6
Autor:
Isaac Vázquez-Mendoza, Erika E. Rodríguez-Torres, Mojgan Ezadian, Lindi M. Wahl, Philip J. Gerrish
Publikováno v:
Axioms, Vol 13, Iss 2, p 117 (2024)
A mutator is a variant in a population of organisms whose mutation rate is higher than the average mutation rate in the population. For genetic and population dynamics reasons, mutators are produced and survive with much greater frequency than anti-m
Externí odkaz:
https://doaj.org/article/160665efb0c94a23a2f50679bba5e645
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational biases that influence genome evolution and adaptation. How do such diverse biases evolve? Our experiments show that changing the mutation spectrum allows popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989b67ef8fb83fa21397dcb9b5de402f
https://doi.org/10.1073/pnas.2207355120
https://doi.org/10.1073/pnas.2207355120
Publikováno v:
Evolution Letters
Evolution Letters, Vol 5, Iss 5, Pp 458-471 (2021)
Evolution Letters, Vol 5, Iss 5, Pp 458-471 (2021)
Although vaccination has been remarkably effective against some pathogens, for others, rapid antigenic evolution results in vaccination conferring only weak and/or short-lived protection. Consequently, considerable effort has been invested in develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b0591d5a660a1f63068241117c206d
http://europepmc.org/articles/PMC8484727
http://europepmc.org/articles/PMC8484727
Recent experimental evidence demonstrates that shifts in mutational biases, for example increases in transversion frequency, can change the distribution of fitness effects of mutations (DFE). In particular, reducing or reversing a prevailing bias can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb45b3ada7d5523d304a0b942ce8ea0
https://doi.org/10.1101/2022.09.27.509708
https://doi.org/10.1101/2022.09.27.509708
Autor:
Harish Chandra Dhakal, Amita Tripathi, Ramesh Chandra Timsina, Khagendra Adhikari, Lindi M. Wahl
Publikováno v:
Journal of Biological Dynamics, Vol 15, Iss 1, Pp 327-341 (2021)
Outbreaks of highly pathogenic strains of avian influenza (HPAI) cause high mortality in avian populations worldwide. When spread from avian reservoirs to humans, HPAI infections cause mortality in about 50% of human infections. Cases of human-to-hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d05d9461586fb59f4d1190d7b14731b
https://doaj.org/article/d98b2573143a47d2a8e0e6ef38729ed9
https://doaj.org/article/d98b2573143a47d2a8e0e6ef38729ed9