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Synthesis and selective ²H-, ¹³C-, and ¹⁵N-labeling of the Tau protein binder THK-523.

Autor: Neumann, Karoline T.¹, Lindhardt, Anders T.² lindhardt@eng.au.dk, Bang ‐ Andersen, Benny³, Skrydstrup, Troels¹ ts@inano.au.dk

Publikováno v: Journal of Labelled Compounds & Radiopharmaceuticals. Jan2017, Vol. 60 Issue 1, p30-35. 6p.

Ex situ generation of stoichiometric HCN and its application in the Pd-catalysed cyanation of aryl bromides: evidence for a transmetallation step between two oxidative addition Pd-complexes† †Electronic supplementary information (ESI) available. CCDC 1504904–1504908. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03912c

Autor: Kristensen, Steffan K., Eikeland, Espen Z., Taarning, Esben, Lindhardt, Anders T., Skrydstrup, Troels

Publikováno v: Chemical Science

We demonstrate how hydrogen cyanide can be exploited for the cyanation of aryl bromides with Pd-catalysis.
A protocol for the Pd-catalysed cyanation of aryl bromides using near stoichiometric and gaseous hydrogen cyanide is reported for the firs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19b5e343cdfd40997f577e5921648763
http://europepmc.org/articles/PMC5855124

Synthesis and selective 2H-, 13C-, and 15N-labeling of the Tau protein binder THK-523

Autor: Neumann, Karoline T., Lindhardt, Anders T., Bang-Andersen, Benny, Skrydstrup, Troels

Publikováno v: Neumann, K T, Lindhardt, A T, Bang-Andersen, B & Skrydstrup, T 2017, ' Synthesis and selective 2 H-, 13 C-, and 15 N-labeling of the Tau protein binder THK-523 ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 1, pp. 30-35 . https://doi.org/10.1002/jlcr.3470

A new synthetic route to the Tau binder, THK-523, is disclosed herein, which can easily be adapted to 13C- and D-isotope labeling. The synthesis proceeds via two key reactions, namely, a Pd-catalyzed carbonylative Sonogashira coupling and a reductive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::ac39ef918d3294236a027c7788b7c426
https://pure.au.dk/portal/da/publications/synthesis-and-selective-2h-13c-and-15nlabeling-of-the-tau-protein-binder-thk523(0bac3259-487f-4bfc-8c18-b1e7cc2dc844).html

2-Pyridyl Tosylate Derivatives-Building Blocks for Structural Diversity via Transition Metal Catalysis.

Autor: Lindhardt, Anders T.¹, Gøgsig, Thomas M.¹, Gauthier, Delphine¹, Lupp, Daniel¹, Mantel, Mette Louise Hallager¹, Bjerglund, Klaus M.¹, Skrydstrup, Troels¹

Publikováno v: Israel Journal of Chemistry. 2010, Vol. 50 Issue 5/6, p558-567. 10p. 17 Diagrams.