Discovery of a dual SENP1 and SENP2 inhibitor

Autor: Brand, Michael, Bommeli, Elias Benjamin, Rütimann, Marc, Lindenmann, Urs, Riedl, Rainer

SUMOylation is a reversible post-translational modification (PTM) involving covalent attachment of small ubiquitin-related modifier (SUMO) proteins to substrate proteins. Dysregulation of SUMOylation and deSUMOylation results in cellular malfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73817feb6785389cc493efd07cbbce3c
https://hdl.handle.net/11475/26647

Discovery of a Dual SENP1 and SENP2 Inhibitor.

Autor: Brand M; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland., Bommeli EB; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland., Rütimann M; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland., Lindenmann U; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland., Riedl R; Institute of Chemistry and Biotechnology, Competence Center for Drug Discovery, Zurich University of Applied Sciences (ZHAW), Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 11; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 11.