Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Linden J. Gearing"'
Autor:
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-
Externí odkaz:
https://doaj.org/article/780fdb67fa074e35823aa88357231e9d
Autor:
Marion C. Bichet, Jack Adderley, Laura Avellaneda-Franco, Isabelle Magnin-Bougma, Natasha Torriero-Smith, Linden J. Gearing, Celine Deffrasnes, Cassandra David, Genevieve Pepin, Michael P. Gantier, Ruby CY Lin, Ruzeen Patwa, Gregory W. Moseley, Christian Doerig, Jeremy J. Barr
Publikováno v:
PLoS Biology, Vol 21, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/87a7aefbd0b44585970f3caf63888312
BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
Autor:
Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source
Externí odkaz:
https://doaj.org/article/55d8f97f36464af78639b6d7c2a5c371
Autor:
Wendy Dankers, Melissa Northcott, Taylah Bennett, Akshay D’Cruz, Rochelle Sherlock, Linden J. Gearing, Paul Hertzog, Brendan Russ, Iolanda Miceli, Sebastian Scheer, Maki Fujishiro, Kunihiro Hayakawa, Keigo Ikeda, Eric F. Morand, Sarah A. Jones
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for SLE treatment but are associated with detrimental metabolic effects. Type 1 interferons (IF
Externí odkaz:
https://doaj.org/article/3505bf1850804a299c6894502a57d398
Autor:
Nollaig M. Bourke, Sharon L. Achilles, Stephanie U-Shane Huang, Helen E. Cumming, San S. Lim, Irene Papageorgiou, Linden J. Gearing, Ross Chapman, Suruchi Thakore, Niamh E. Mangan, Sam Mesiano, Paul J. Hertzog
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Although published studies have demonstrated that IFN-ε has a crucial role in regulating protective immunity in the mouse female reproductive tract, expression and regulation of IFN-ε in the human female reproductive tract (hFRT) have not been char
Externí odkaz:
https://doaj.org/article/617002a4f4874767b54742108c6286e8
Autor:
Melissa Northcott, Linden J. Gearing, Julie Bonin, Rachel Koelmeyer, Alberta Hoi, Paul J. Hertzog, Eric F. Morand
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectivesThe analysis of gene module expression in SLE is emerging as a tool to identify active biological pathways, with the aim of developing targeted therapies for subsets of patients. Detailed information on the effect of immunosuppressants on g
Externí odkaz:
https://doaj.org/article/12e3786e48b141e0b7b5099a6b5d3f2d
Autor:
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
Externí odkaz:
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977
Autor:
Pacôme B. Prompsy, John Toubia, Linden J. Gearing, Randle L. Knight, Samuel C. Forster, Cameron P. Bracken, Michael P. Gantier
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4896-4903 (2021)
microRNAs (miRNAs) are important modulators of messenger RNA stability and translation, controlling wide gene networks. Albeit generally modest on individual targets, the regulatory effect of miRNAs translates into meaningful pathway modulation throu
Externí odkaz:
https://doaj.org/article/7b91726759744c218543e3f0c73fa62e
Autor:
Alice J. West, Virginie Deswaerte, Alison C. West, Linden J. Gearing, Patrick Tan, Brendan J. Jenkins
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Inflammasomes are important multiprotein regulatory complexes of innate immunity and have recently emerged as playing divergent roles in numerous inflammation-associated cancers. Among these include gastric cancer (GC), the third leading cause of can
Externí odkaz:
https://doaj.org/article/0161cb08d9434250896fc71c7009df74
Autor:
Christina F. Budden, Linden J. Gearing, Romina Kaiser, Lena Standke, Paul J. Hertzog, Eicke Latz
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 10, Pp n/a-n/a (2021)
Abstract Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. These mechanisms evolved to curb the spread of microbes and to induce repair of the damaged tissue. Chronic activat
Externí odkaz:
https://doaj.org/article/656533e82de9493cb7c7b1110c12fae3