Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Linde Robert Gerald"'
Autor:
Lilli Ann Wolf-Gouveia, Paul D. Lira, Eric B. McElroy, Lisa Marie Thomasco, Matthew Frank Brown, Christopher S. Jones, Jonathan L. Doty, Lawrence A. Reiter, Sandra P. McCurdy, Anthony Marfat, Sharon L. Ripp, Mark J. Mitton-Fry, William H. Brissette, Andrei Shavnya, Linde Robert Gerald, Thomas M. Harris, Kristen A. Trevena, Qifang Li, Laura Cook Blumberg, Amy S. Antipas, James P. Driscoll, Michael John Munchhof, Jeffrey M. Casavant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1428-1430
Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c13f353a20302d8bc86c0f3e090d44
https://doi.org/10.1016/j.bmcl.2009.01.032
https://doi.org/10.1016/j.bmcl.2009.01.032
Autor:
Steven M. Finegan, Shigeru F. Hayashi, Arthur E. Girard, J. C. Kane, R.Y. Chandrasekaran, S. A. Kaufman, N. C. Birsner, J.W. Petitpas, B.V. Yang, David A. Whipple, J.P. Lyssikatos, Catherine P. Reese, C.P. MacLelland, Barbara J. Kamicker, B. J. Cronin, S. A. Miller, Joanna Clancy, Susan A. Froshauer, Magee Thomas Victor, B. P. Dirlam, M. A. Lemay, John P. Dirlam, Scott B. Seibel, Wei-Guo Su, Linde Robert Gerald, R. R. Brooks, A. M. Belton, Mark A. Massa, K. T. Sweeney, Martha L. Minich, R. J. Howe, David Austen Perry, Shang-Poa Chang, Nicole L. Kolosko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1139-1144
A 6a-(3′,4′-dichlorophenylamino) analog of viomycin was uncovered by a high-throughput screen against the animal health pathogen Pasteurella haemolytica, and has served as a novel lead structure for our infectious disease programs. We report here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35767df2d0f2186d70412a3ef308451
https://doi.org/10.1016/s0960-894x(97)00186-8
https://doi.org/10.1016/s0960-894x(97)00186-8
Autor:
Arthur E. Girard, J.W. Petitpas, J.P. Lyssikatos, Steven M. Finegan, A.S. Lee, D.P. Larson, John P. Dirlam, Scott B. Seibel, Linde Robert Gerald, C.B. Vu, Shang-Poa Chang, C.P. MacLelland, Joanna Clancy, Shigeru F. Hayashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1145-1148
This paper describes synthetic modifications of the C-19 position of tuberactinomycin B (viomycin) and related analogs. The in vitro antibacterial activity of selected analogs against Pasteurella multocida, Escherichia coli and methicillin-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6113bdfa10f31278f2c24379173f92
https://doi.org/10.1016/s0960-894x(97)00187-x
https://doi.org/10.1016/s0960-894x(97)00187-x
Autor:
J. P. Rainville, Linde Robert Gerald, N. C. Birsner, Wei-Guo Su, David A. Whipple, R. J. Howe, C.P. MacLelland, Magee Thomas Victor, Joanna Clancy, Ramalakshmi Yegna Chandrasekaran, J.W. Petitpas, J.P. Lyssikatos, C.B. Vu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1149-1152
Modification and replacement of the β-lysine side chain of capreomycin and tuberactinomycin cyclic pentapeptide derivatives resulted in compounds with good antibacterial potency against multidrug-resistant pathogens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7bf9fb3226ec3bd54dc913dec7313d9
https://doi.org/10.1016/s0960-894x(97)00188-1
https://doi.org/10.1016/s0960-894x(97)00188-1
Autor:
David A. Whipple, Susan A. Froshauer, Wei-Guo Su, R. J. Howe, N. C. Birsner, Shigeru F. Hayashi, R. R. Brooks, Steven M. Finegan, Barbara J. Kamicker, K. T. Sweeney, A. M. Belton, John P. Dirlam, Scott B. Seibel, Linde Robert Gerald, Catherine P. Reese, Mark A. Massa, David Austen Perry, Nicole L. Kolosko, S. A. Miller, B. P. Dirlam, C.P. MacLelland, M. A. Lemay, J. C. Kane, Arthur E. Girard, J.W. Petitpas, J.P. Lyssikatos, Bingwei Yang, S. A. Kaufman, Martha L. Minich, Shang-Poa Chang, Magee Thomas Victor, Joanna Clancy, Ramalakshmi Yegna Chandrasekaran, B. J. Cronin
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2401e93966d997df88ad5a4e9a3175e
https://doi.org/10.1002/chin.199740236
https://doi.org/10.1002/chin.199740236
Autor:
J. P. Rainville, N. C. Birsner, David A. Whipple, J.W. Petitpas, J.P. Lyssikatos, Wei-Guo Su, Joanna Clancy, Linde Robert Gerald, Ramalakshmi Yegna Chandrasekaran, R. J. Howe, Magee Thomas Victor, C.B. Vu, C.P. MacLelland
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::791670d0f6d43fac5d8a2e4e7f45f983
https://doi.org/10.1002/chin.199740237
https://doi.org/10.1002/chin.199740237
Autor:
Diana Sperger, Laura Cook Blumberg, Emilio J. Mangual, Kristen A. Trevena, Christopher S. Jones, Jonathan L. Doty, Fangning Zhang, William H. Brissette, Marc I. Smeets, Qifang Li, Paul D. Lira, Amy S. Antipas, Lilli Ann Wolf-Gouveia, Sandra P. McCurdy, Lisa Marie Thomasco, Andrei Shavnya, Sharon L. Ripp, Richard M. Shepard, Liling Zhang, Chakrapani Subramanyam, Linde Robert Gerald, Michael John Munchhof, Lawrence A. Reiter, James P. Driscoll
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(19)
A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28920ad58a16caa053bbc11c89c4ece
https://pubmed.ncbi.nlm.nih.gov/17707640
https://pubmed.ncbi.nlm.nih.gov/17707640
Publikováno v:
Annual Reports in Medicinal Chemistry ISBN: 9780120405343
Publisher Summary This chapter focuses on new antibacterials for resistant organisms. The last decade of the 20th century brought with it vancomycin-resistant S. aureus . These glycopeptide intermediate resistant strains (GISA) may receive the most p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a237fd0318c7445a43148d366b9dd15
https://doi.org/10.1016/s0065-7743(08)60579-5
https://doi.org/10.1016/s0065-7743(08)60579-5
