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LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endotheliums.

Autor: Zhang H; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam., Hansen M; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam., Di Summa F; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam., Von Lindern M; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam., Gillemans N; Department of Cell Biology, Erasmus MC, Rotterdam., Van IJcken WFJ; Center for Biomics, Erasmus MC, Rotterdam., Svendsen AF; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam., Philipsen S; Department of Cell Biology, Erasmus MC, Rotterdam., Van der Reijden B; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen., Varga E; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam., Van den Akker E; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam. e.vandenakker@sanquin.nl.

Publikováno v: Haematologica [Haematologica] 2024 Jul 04. Date of Electronic Publication: 2024 Jul 04.

The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells.

Autor: Petkova-Kirova P; Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.; Department of Biochemistry, Saarland University, 66123 Saarbrücken, Germany., Murciano N; Nanion Technologies, 80339 Munich, Germany.; Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, 66421 Homburg, Germany., Iacono G; Department of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands.; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1007 MB Amsterdam, The Netherlands., Jansen J; Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, 66421 Homburg, Germany.; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany., Simionato G; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany.; Department of Experimental Surgery, Campus University Hospital, Saarland University, 66421 Homburg, Germany., Qiao M; Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, 66421 Homburg, Germany.; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany., Van der Zwaan C; Department of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands.; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1007 MB Amsterdam, The Netherlands., Rotordam MG; Nanion Technologies, 80339 Munich, Germany., John T; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany., Hertz L; Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, 66421 Homburg, Germany.; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany., Hoogendijk AJ; Department of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands.; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1007 MB Amsterdam, The Netherlands., Becker N; Nanion Technologies, 80339 Munich, Germany., Wagner C; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany.; Physics and Materials Science Research Unit, University of Luxembourg, L-1511 Luxembourg, Luxembourg., Von Lindern M; Department of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands.; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1007 MB Amsterdam, The Netherlands., Egee S; Biological Station Roscoff, Sorbonne University, CNRS, UMR8227 LBI2M, F-29680 Roscoff, France.; Laboratory of Excellence GR-Ex, F-75015 Paris, France., Van den Akker E; Department of Hematopoiesis, Sanquin Research, 1066 CX Amsterdam, The Netherlands.; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1007 MB Amsterdam, The Netherlands., Kaestner L; Theoretical Medicine and Biosciences, Campus University Hospital, Saarland University, 66421 Homburg, Germany.; Department of Experimental Physics, Saarland University, 66123 Saarbrücken, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 24; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 24.

Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells.

Autor: Gallego-Murillo JS; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center (UMC), Amsterdam, The Netherlands.; Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.; Meatable, Alexander Fleminglaan 1, 2613AX, Delft, The Netherlands., Yağcı N; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center (UMC), Amsterdam, The Netherlands., Pinho EM; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center (UMC), Amsterdam, The Netherlands.; Department of Bioengineering, Faculty of Engineering, University of Porto, Porto, Portugal., Wahl SA; Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.; Lehrstuhl Für Bioverfahrenstechnik, Friedrich-Alexander Universität Erlangen-Nürnberg, Paul-Gordan-Str. 3, 91052, Erlangen, Germany., van den Akker E; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center (UMC), Amsterdam, The Netherlands., von Lindern M; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center (UMC), Amsterdam, The Netherlands. m.vonlindern@sanquin.nl.

Publikováno v: Scientific reports [Sci Rep] 2023 Apr 28; Vol. 13 (1), pp. 6960. Date of Electronic Publication: 2023 Apr 28.

Mammalian life depends on two distinct pathways of DNA damage tolerance.

Autor: Buoninfante OA; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Pilzecker B; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Spanjaard A; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., de Groot D; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Prekovic S; Division of Oncogenomics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.; Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands., Song JY; Division of Experimental Animal Pathology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Lieftink C; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute Robotics and Screening Center, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Ayidah M; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Pritchard CEJ; Mouse Clinic for Cancer and Aging Research, Transgenic Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Vivié J; Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, The Netherlands., Mcgrath KE; Department of Pediatrics, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY 14642., Huijbers IJ; Mouse Clinic for Cancer and Aging Research, Transgenic Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Philipsen S; Department of Cell Biology, Erasmus Medical Center, 3015CN Rotterdam, The Netherlands., von Lindern M; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratories, 1066CX Amsterdam, The Netherlands., Zwart W; Division of Oncogenomics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Beijersbergen RL; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute Robotics and Screening Center, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Palis J; Department of Pediatrics, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY 14642., van den Berk PCM; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Jacobs H; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2216055120. Date of Electronic Publication: 2023 Jan 20.