Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Linda-Isabell Schmitt"'
Autor:
Markus Leo, Linda-Isabell Schmitt, Fabian Mairinger, Andreas Roos, Christina Hansmann, Stefanie Hezel, Jelena Skuljec, Refik Pul, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Tim Hagenacker
Publikováno v:
Cells, Vol 12, Iss 19, p 2374 (2023)
5q-related Spinal muscular atrophy (SMA) is a hereditary multi-systemic disorder leading to progressive muscle atrophy and weakness caused by the degeneration of spinal motor neurons (MNs) in the ventral horn of the spinal cord. Three SMN-enhancing d
Externí odkaz:
https://doaj.org/article/f0c4e965a11049a49b14bcde21c3a753
Autor:
Markus Leo, Linda-Isabell Schmitt, Michael Fleischer, Rebecca Steffen, Cora Osswald, Christoph Kleinschnitz, Tim Hagenacker
Publikováno v:
Cells, Vol 11, Iss 3, p 558 (2022)
Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mo
Externí odkaz:
https://doaj.org/article/1e026c316868411197eaee4b0219ae76
Autor:
Linda-Isabell Schmitt, Christina David, Rebecca Steffen, Stefanie Hezel, Andreas Roos, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Markus Leo, Tim Hagenacker
Publikováno v:
Acta Neuropathologica. 145:611-635
Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by a loss of the survival of motor neuron 1 (SMN1) gene, resulting in a loss of spinal motor neurons (MNs), leading to muscle weakness and wasting. The pathogenesis of MN lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a633368c8d09477c7756ca5c32db6261
https://doi.org/10.1007/s00401-023-02554-4
https://doi.org/10.1007/s00401-023-02554-4
Autor:
Tayana Silva de Carvalho, Dirk M. Hermann, Santiago Camblor-Perujo, Kathy Keyvani, Tim Hagenacker, Eduardo H. Sanchez-Mendoza, Christoph Kleinschnitz, Sujoy Bera, Michael Fleischer, Linda-Isabell Schmitt, Natalia L. Kononenko, Luiza Martins Nascentes-Melo, Egor Dzyubenko, Markus Leo, Arne Herring
Publikováno v:
Molecular Neurobiology
Disrupted neuronal plasticity due to subtle inflammation is considered to play a fundamental role in the pathogenesis of major depressive disorder. Interferon-α (IFN-α) potentiates immune responses against viral pathogens that induce toll-like rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac84c82097f3b6150435fcf159bf8e96
https://doi.org/10.1007/s12035-020-01927-0
https://doi.org/10.1007/s12035-020-01927-0
Autor:
Markus Leo, Linda-Isabell Schmitt, Michael Fleischer, Rebecca Steffen, Cora Osswald, Christoph Kleinschnitz, Tim Hagenacker
Publikováno v:
Cells; Volume 11; Issue 3; Pages: 558
Cells, Vol 11, Iss 558, p 558 (2022)
Cells, Vol 11, Iss 558, p 558 (2022)
Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bd6fcba9fd9b92dd727113e02d3390
https://pubmed.ncbi.nlm.nih.gov/35159369
https://pubmed.ncbi.nlm.nih.gov/35159369
Cisplatin plays an essential role in the treatment of various cancers. Cisplatin exhibits high efficacy, but it often leads to severe neurotoxic side effects, such as chemotherapy-induced polyneuropathy (CIPN). The pathophysiology of CIPN is not full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ea3a448409fe30fb0007cc409560ee
https://www.ncbi.nlm.nih.gov/pubmed/33727094
https://www.ncbi.nlm.nih.gov/pubmed/33727094
Autor:
Markus Leo, Linda-Isabell Schmitt, Patricia Küsterarent, Andrea Kutritz, Tienush Rassaf, Christoph Kleinschnitz, Ulrike B. Hendgen-Cotta, Tim Hagenacker
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8636, p 8636 (2020)
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8636, p 8636 (2020)
Cisplatin and oxaliplatin are treatment options for a variety of cancer types. While highly efficient in killing cancer cells, both chemotherapeutics cause severe side effects, e.g., peripheral neuropathies. Using a cell viability assay, a mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6c95b41c482ccb033938622e8c2fc5b7
https://duepublico2.uni-due.de/receive/duepublico_mods_00073688
https://duepublico2.uni-due.de/receive/duepublico_mods_00073688
Platinum-based chemotherapeutics still play an important role in cancer therapy, however, severe side effects, such as painful neuropathy, occur frequently. The pathophysiologic mechanisms depend on the applied chemotherapeutic agent and are still co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a56050a88ed40395f4e77ec1ea4fbff
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85084982254
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85084982254
Oxaliplatin is important for treating colorectal cancer. Although oxaliplatin is highly effective, it has severe side effects, of which neurotoxicity in dorsal root ganglion (DRG) neurons is one of the most common. The key mechanisms of this neurotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3076917d558c4bac537309fdc7746f7
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85044586635
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85044586635
Autor:
Holger Jastrow, Christoph Kleinschnitz, Linda-Isabell Schmitt, Markus Leo, Tim Hagenacker, Jürgen Thomale
Publikováno v:
Molecular Pain
Platinum-based chemotherapeutic agents, such as cisplatin, are still frequently used for treating various types of cancer. Besides its high effectiveness, cisplatin has several serious side effects. One of the most common side effects is dorsal root
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e281cf4e32a0b8e629512754074798e
https://pubmed.ncbi.nlm.nih.gov/29166837
https://pubmed.ncbi.nlm.nih.gov/29166837