Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study

Autor: Simon C Mendelsohn, MBChB, Andrew Fiore-Gartland, PhD, Adam Penn-Nicholson, PhD, Humphrey Mulenga, MPH, Stanley Kimbung Mbandi, PhD, Bhavesh Borate, MS, Katie Hadley, PhD, Chris Hikuam, PhD, Munyaradzi Musvosvi, PhD, Nicole Bilek, PhD, Mzwandile Erasmus, BSc, Lungisa Jaxa, BTech, Rodney Raphela, BSc, Onke Nombida, GT, Masooda Kaskar, MBChB, Tom Sumner, PhD, Richard G White, PhD, Craig Innes, MBChB, William Brumskine, MBChB, Andriëtte Hiemstra, MBChB, Stephanus T Malherbe, MBChB, Razia Hassan-Moosa, MPH, Michèle Tameris, MBChB, Gerhard Walzl, MBChB, Kogieleum Naidoo, PhD, Gavin Churchyard, PhD, Thomas J Scriba, DPhil, Mark Hatherill, ProfMD, Charmaine Abrahams, Hadn Africa, Petri Ahlers, Denis Arendsen, Tebogo Badimo, Kagiso Baepanye, Kesenogile Edna Baepanye, Bianca Bande, Nomfuneko Cynthia Batyi, Roslyn Beukes, Laudicia Tshenolo Bontsi, Obakeng Peter Booi, Mari Cathrin Botha, Samentra Braaf, Sivuyile Buhlungu, Alida Carstens, Kgomotso Violet Chauke, Thilagavathy Chinappa, Eva Chung, Michelle Chung, Ken Clarke, Yolundi Cloete, Lorraine Coetzee, Marelize Collignon, Alessandro Companie, Cara-mia Corris, Mooketsi Theophillius Cwaile, Thobelani Cwele, Ilse Davids, Isabella Johanna Davies, Emilia De Klerk, Marwou de Kock, Audrey Lebohang Dhlamini, Bongani Diamond, Maria Didloff, Celaphiwe Dlamini, Palesa Dolo, Candice Eyre, Tebogo Feni, Juanita Ferreira, Christal Ferus, Michelle Fisher, Marika Flinn, Bernadine Fransman, Welseh Phindile Galane, Hennie Geldenhuys, Diann Gempies, Thelma Goliath, Dhineshree Govender, Yolande Gregg, Goodness Gumede, Zanele Gwamada, Senzo Halti, Rieyaat Hassiem, Roxane Herling, Yulandi Herselman, Ellis Hughes, Henry Issel, Blanchard Mbay Iyemosolo, Zandile Jali, Bonita Janse Van Rensburg, Ruwiyda Jansen, James Michael Jeleni, Olebogeng Jonkane, Fabio Julies, Fazlin Kafaar, Christian Mabika Kasongo, Sophie Keffers, Boitumelo Sophy Kekana, Sebaetseng Jeanette Kekana, Xoliswa Kelepu, Lungile Khanyile, Gomotsegang Virginia Khobedi, Gloria Khomba, Lucky Sipho Khoza, Marietjie King, Gloria Keitumetse Kolobe, Sandra Kruger, Jaftha Kruger, Ndlela Israel Kunene, Sunelza Lakay, Aneesa Lakhi, Nondumiso Langa, Hildah Ledwaba, Lerato Julia Lekagane, Sheiley Christina Lekotloane, Thelma Leopeng, Ilze Jeanette Louw, Angelique Kany Kany Luabeya, Sarah Teboso Lusale, Perfect Tiisetso Maatjie, Immaculate Mabasa, Tshegofatso Dorah Mabe, Kamogelo Fortunate Mabena, Nkosinathi Charles Mabuza, Simbarashe Mabwe, Johanna Thapelo Madikwe, Octavia Mahkosazana Madikwe, Rapontwana Letlhogonolo Maebana, Malobisa Sylvester Magwasha, Molly Majola, Mantai Makhetha, Lebohang Makhethe, Vernon Malay, Vutlhari-I-Vunhenha Fairlord Manzini, Jabu Maphanga, Nonhle Maphanga, Juanita Market, Isholedi Samuel Maroele, Omphile Petunia Masibi, July Rocky Mathabanzini, Tendamudzimu Ivan Mathode, Ellen Ditaba Matsane, Lungile Mbata, Faheema Meyer, Nyasha Karen Mhandire, Thembisiwe Miga, Nosisa Charity Thandeka Mkhize, Caroline Mkhokho, Neo Hilda Mkwalase, Nondzakazi Mnqonywa, Karabo Moche, Brenda Matshidiso Modisaotsile, Patricia Pakiso Mokgetsengoane, Selemeng Matseliso Carol Mokone, Kegomoditswe Magdeline Molatlhegi, Thuso Andrew Molefe, Joseph Panie Moloko, Kabelo Molosi, Motlatsi Evelyn Molotsi, Tebogo Edwin Montwedi, Boikanyo Dinah Monyemangene, Hellen Mokopi Mooketsi, Miriam Moses, Boitumelo Mosito, Tshplpfelo Mapula Mosito, Ireen Lesebang Mosweu, Primrose Mothaga, Banyana Olga Motlagomang, Angelique Mouton, Onesisa Mpofu, Funeka Nomvula Mthembu, Mpho Mtlali, Nhlamulo Ndlovu, Nompumelelo Ngcobo, Julia Noble, Bantubonke Bertrum Ntamo, Gloria Ntanjana, Tedrius Ntshauba, Fajwa Opperman, Nesri Padayatchi, Thandiwe Papalagae, Christel Petersen, Themba Phakathi, Mapule Ozma Phatshwane, Patiswa Plaatjie, Abe Pretorius, Victor Kgothatso Rameetse, Dirhona Ramjit, Frances Ratangee, Maigan Ratangee, Pearl Nomsa Sanyaka, Alicia Sato, Elisma Schoeman, Constance Schreuder, Letlhogonolo Seabela, Kelebogile Magdeline Segaetsho, Ni Ni Sein, Raesibe Agnes Pearl Selepe, Melissa Neo Senne, Alison September, Cashwin September, Moeti Serake, Justin Shenje, Thandiwe Shezi, Sifiso Cornelius Shezi, Phindile Sing, Chandrapharbha Singh, Zona Sithetho, Dorothy Solomons, Kim Stanley, Marcia Steyn, Bongiwe Stofile, Sonia Stryers, Liticia Swanepoel, Anne Swarts, Mando Mmakhora Thaba, Lethabo Collen Theko, Philile Thembela, Mugwena Thompo, Asma Toefy, Khayalethu Toto, Dimakatso Sylvia Tsagae, Ayanda Tsamane, Vincent Tshikovhi, Lebogang Isaac Tswaile, Petrus Tyambetyu, Susanne Tönsing, Habibullah Valley, Linda van der Merwe, Elma van Rooyen, Ashley Veldsman, Helen Veldtsman, Kelvin Vollenhoven, Londiwe Zaca, Elaine Zimri, Mbali Zulu

Publikováno v: The Lancet Global Health, Vol 9, Iss 6, Pp e841-e853 (2021)

Summary: Background: A rapid, blood-based triage test that allows targeted investigation for tuberculosis at the point of care could shorten the time to tuberculosis treatment and reduce mortality. We aimed to test the performance of a host blood tra

Externí odkaz: https://doaj.org/article/abc3602cf70749b5a1d464dd9cecb502

Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial

Autor: Julia Amsterdam, Alessandro Companie, Fajwa Opperman, Justin Shenje, Steven G. Reed, Elma Van Rooyen, Sandra Goliath, Julia Noble, Tom Rolf, Friedrich Thienemann, Ann Swarts, Rhea N. Coler, Amaryl Van Schalkwyk, Linda-Gail Bekker, Sarah Albertson, Alessandro Sette, Erica Smit, Angelique Mouton, Michele Tameris, Zachary K. Sagawa, Lebohang Makhethe, Yolandi Herselman, Aude Frevol, Yolundi Cloete, Simbarashe Mabwe, Nicole Bilek, Angelique Kany Kany Luabeya, Alana Keyser, Cecilia S. Lindestam Arlehamn, Andrew Fiore-Gartland, Tracey A. Day, Asma Toefy, Carolyn Jones, Thomas J. Scriba, Linda van der Merwe, Constance Schreuder, Natasja Botes, Susan Rossouw, Andreas H. Diacon, Humphrey Mulenga, Adam Penn-Nicholson, Devona Hofmeester, Sandra Kruger, Nelita du Plessis, Fan-Chi Hsu, Jill A. Ashman, Julie Vergara, Anna Marie Beckmann, Eunice Sinandile, Andre G. Loxton, Elisabeth Filander, Ashley Veldsman, Andrea Gutschmidt, Marwou de Kock, Leya Hassanally, Hadn Africa, Stuart Kahn, Yiwen Lu, Marcia Steyn, Timothy D. Reid, Gerhard Walzl, Gail Jacobs, Elize van der Riet, Mark Hatherill, Cynthia Ontong, Nambitha Quaqua, H. Geldenhuys

Publikováno v: The Lancet. Respiratory medicine. 9(4)

Summary Background A therapeutic vaccine that prevents recurrent tuberculosis would be a major advance in the development of shorter treatment regimens. We aimed to assess the safety and immunogenicity of the ID93 + GLA-SE vaccine at various doses an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d96a462b60fe3106efce2a93cd09ebd
https://pubmed.ncbi.nlm.nih.gov/34214500

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG

Autor: Hennie Geldenhuys, Robert Walker, Linda van der Merwe, Marwou de Kock, Helen McShane, Gregory D. Hussey, Bernard Landry, Thomas J. Scriba, Jacqui Shea, Mark Hatherill, J. Bruce McClain, Michele Tameris, Hassan Mahomed, Stephen Lockhart, Willem A. Hanekom, Angelique Kany Kany Luabeya

Publikováno v: Tuberculosis (Edinburgh, Scotland)

Background: New tuberculosis (TB) vaccines are being developed to combat the global epidemic. A phase IIb trial of a candidate vaccine, MVA85A, was conducted in a high burden setting in South Africa to evaluate proof-of-concept efficacy for preventio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415c5ec7e717f141ab533ea35a7b38ab
https://ora.ox.ac.uk/objects/uuid:7449806e-2aa0-462f-9dd7-3bd4a50cf2c4

A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults

Autor: Helen McShane, Thomas J. Scriba, Adrian V. S. Hill, Sebastian Gelderbloem, Humphrey Mulenga, Erica Smit, Michele Tameris, Lebohang Makhethe, Esme Janse van Rensburg, H. Geldenhuys, Hassan Mahomed, Willem A. Hanekom, Sizulu Moyo, Anthony Hawkridge, Katya Mauff, Gregory D. Hussey, Ashley Veldsman, Linda van der Merwe, Nathaniel Brittain, E. Jane Hughes, Alison M. Lawrie, Mark Hatherill, Blessing Kadira, Marwou de Kock

RATIONALE: Novel tuberculosis (TB) vaccines should be safe and effective in populations infected with Mycobacterium tuberculosis (M.tb) and/or HIV for effective TB control. OBJECTIVE: To determine the safety and immunogenicity of MVA85A, a novel TB v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af96df0967024ce640bd0769fad43105
https://ora.ox.ac.uk/objects/uuid:56faaaa7-18af-4ab2-9293-960f3aba3c73

The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+and CD8+T Cells in Adults

Autor: J. Bruce McClain, Deborah Abrahams, Hassan Mahomed, Mzwandile Erasmus, Gregory D. Hussey, Willem A. Hanekom, Nazma Mansoor, Donata Sizemore, Anthony Hawkridge, Jerald C. Sadoff, Mark Hatherill, Maria Grazia Pau, Sebastian Gelderbloem, Giulia Schirru, M.A. Goetz, Brian Abel, Linda van der Merwe, Jenny Hendriks, Jaap Goudsmit, Jane Hughes, Ashley Veldsman, Gerrit Jan Weverling, Marwou de Kock, Jacqueline Gearhart, Michele Tameris, Lebohang Makhethe

Publikováno v: American journal of respiratory and critical care medicine, 181(12), 1407-1417. American Thoracic Society

RATIONALE: AERAS-402 is a novel tuberculosis vaccine designed to boost immunity primed by bacillus Calmette-Guérin (BCG), the only licensed vaccine. OBJECTIVES: We investigated the safety and immunogenicity of AERAS-402 in healthy Mycobacterium tube

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c330e8ff0f930082167d8a9f148900c
https://doi.org/10.1164/rccm.200910-1484oc