Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants

Autor: Linda van Oosten, Jort J. Altenburg, Cyrielle Fougeroux, Corinne Geertsema, Fred van den End, Wendy A. C. Evers, Adrie H. Westphal, Simon Lindhoud, Willy van den Berg, Daan C. Swarts, Laurens Deurhof, Andreas Suhrbier, Thuy T. Le, Shessy Torres Morales, Sebenzile K. Myeni, Marjolein Kikkert, Adam F. Sander, Willem Adriaan de Jongh, Robert Dagil, Morten A. Nielsen, Ali Salanti, Max Søgaard, Timo M. P. Keijzer, Dolf Weijers, Michel H. M. Eppink, René H. Wijffels, Monique M. van Oers, Dirk E. Martens, Gorben P. Pijlman

Publikováno v: mBio, Vol 12, Iss 5 (2021)

Vaccines pave the way out of the SARS-CoV-2 pandemic. We have developed a virus-like particle (VLP)-based vaccine using the baculovirus-insect cell expression system, a robust production platform known for its scalability, low cost, and safety. Bacul

Externí odkaz: https://doaj.org/article/9d799f0e15554e7aafc11f877069c7c0

Author response for 'Real‐time online monitoring of insect cell proliferation and baculovirus infection using digital differential holographic microscopy and machine learning'

Autor: null Jort J. Altenburg, null Maarten Klaverdijk, null Damien Cabosart, null Laurent Desmecht, null Sonja S. Brunekreeft‐Terlouw, null Joshua Both, null Vivian I. P. Tegelbeckers, null Marieke L. P. M. Willekens, null Linda van Oosten, null Tessy A. H. Hick, null Tom M. H. van der Aalst, null Gorben P. Pijlman, null Monique M. van Oers, null René H. Wijffels, null Dirk E. Martens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97a8b22c100f47103a9c0bf413634da9
https://doi.org/10.1002/btpr.3318/v2/response1

Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants

Autor: Monique M. van Oers, Thuy T. Le, Robert Dagil, Cyrielle Fougeroux, Willy A. M. van den Berg, Marjolein Kikkert, Adam F. Sander, Adrie H. Westphal, Simon Lindhoud, Andreas Suhrbier, Ali Salanti, Willem A. de Jongh, M.H.M. Eppink, Jort J Altenburg, Dolf Weijers, René H. Wijffels, Dirk E. Martens, Corinne Geertsema, Fred van den End, Gorben P. Pijlman, Timo M P Keijzer, Linda van Oosten, Sebenzile K. Myeni, Wendy A. C. Evers, Max Søgaard, Daan C. Swarts, Morten Nielsen, Laurens Deurhof, Shessy Torres Morales

Publikováno v: mBio
mBio, 12(5)
mBio, Vol 12, Iss 5 (2021)
van Oosten, L, Altenburg, J J, Fougeroux, C, Geertsema, C, van den End, F, Evers, W A C, Westphal, A H, Lindhoud, S, van den Berg, W, Swarts, D C, Deurhof, L, Suhrbier, A, Le, T T, Torres Morales, S, Myeni, S K, Kikkert, M, Sander, A F, de Jongh, W A, Dagil, R, Nielsen, M A, Salanti, A, Søgaard, M, Keijzer, T M P, Weijers, D, Eppink, M H M, Wijffels, R H, van Oers, M M, Martens, D E & Pijlman, G P 2021, ' Two-component nanoparticle vaccine displaying glycosylated spike S1 domain induces neutralizing antibody response against SARS-CoV-2 variants ', mBio, vol. 12, no. 5, e0181321 . https://doi.org/10.1128/mBio.01813-21
mBio, 12(5). AMER SOC MICROBIOLOGY
mBio 12 (2021) 5

Vaccines pave the way out of the SARS-CoV-2 pandemic. Besides mRNA and adenoviral vector vaccines, effective protein-based vaccines are needed for immunization against current and emerging variants. We have developed a virus-like particle (VLP)-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8db209b3e1c1c28cd9e0fa385cc3a9

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Autor: Robert Dagil, Gorben P. Pijlman, Søren R. Paludan, Susan Thrane, Anette Strøbæk, Tim J. Dalebout, Blanka W. Nalewajek, Tanja Domeyer, Laura F. Andersson, Sebenzile K. Myeni, Susheel K. Singh, Anette Stryhn Buus, Michael Theisen, Vladislav Soroka, Thomas M. Hulen, Søren Buus, Emma W. Horsted, Stine B. Clemmensen, Thor G. Theander, Laurits Fredsgaard, Cyrielle Fougeroux, Magdalena Skrzypczak, Ali Salanti, Benjamin Mordmüller, Manja Idorn, Louise Goksøyr, Kasper Iversen, Max Søgaard, Jerzy Dorosz, Asier Garcia-Senosiain, Sayit Mahmut Erdoğan, Line S. Reinert, Tobias Gustavsson, Morten Nielsen, Lene Holm Harritshøj, Bettina Hierzberger, Marjolein Kikkert, Henrik Ullum, Paul Khalifé, Swati Choudhary, Adam F. Sander, Kara Lee Aves, Christoph M. Janitzek, Willem A. de Jongh, Elena Ethel Vidal-Calvo, Jan Pravsgaard Christensen, Linda van Oosten

Publikováno v: Nature Communications 12 (2021) 1
Nature Communications
Nature Communications, 12(1)
Nature Communications, 12(1). NATURE RESEARCH
Fougeroux, C, Goksøyr, L, Idorn, M, Soroka, V, Myeni, S K, Dagil, R, Janitzek, C M, Søgaard, M, Aves, K-L, Horsted, E W, Erdogan, S M, Gustavsson, T, Dorosz, J, Clemmensen, S, Fredsgaard, L, Thrane, S, Vidal-Calvo, E E, Khalifé, P, Hulen, T M, Choudhary, S, Theisen, M, Singh, S K, Garcia-Senosiain, A, Van Oosten, L, Pijlman, G, Hierzberger, B, Domeyer, T, Nalewajek, B W, Strøbæk, A, Skrzypczak, M, Andersson, L F, Buus, S, Buus, A S, Christensen, J P, Dalebout, T J, Iversen, K, Harritshøj, L H, Mordmüller, B, Ullum, H, Reinert, L S, de Jongh, W A, Kikkert, M, Paludan, S R, Theander, T G, Nielsen, M A, Salanti, A & Sander, A F 2021, ' Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity ', Nature Communications, vol. 12, no. 1, pp. 324 . https://doi.org/10.1038/s41467-020-20251-8
Fougeroux, C, Goksøyr, L, Idorn, M, Soroka, V, Myeni, S K, Dagil, R, Janitzek, C M, Søgaard, M, Aves, K L, Horsted, E W, Erdoğan, S M, Gustavsson, T, Dorosz, J, Clemmensen, S, Fredsgaard, L, Thrane, S, Vidal-Calvo, E E, Khalifé, P, Hulen, T M, Choudhary, S, Theisen, M, Singh, S K, Garcia-Senosiain, A, Van Oosten, L, Pijlman, G, Hierzberger, B, Domeyer, T, Nalewajek, B W, Strøbæk, A, Skrzypczak, M, Andersson, L F, Buus, S, Buus, A S, Christensen, J P, Dalebout, T J, Iversen, K, Harritshøj, L H, Mordmüller, B, Ullum, H, Reinert, L S, de Jongh, W A, Kikkert, M, Paludan, S R, Theander, T G, Nielsen, M A, Salanti, A & Sander, A F 2021, ' Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity ', Nature Communications, vol. 12, no. 1, 324 . https://doi.org/10.1038/s41467-020-20251-8
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

The rapid development of a SARS-CoV-2 vaccine is a global priority. Here, we develop two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. RBD antigens are displayed on AP205 CLPs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629100e7a257ffdd8c96de7cbdc0c98f