Regulatory T cells and progenitor B cells are independent prognostic predictors in lower risk myelodysplastic syndromes

Autor: Josephine D. Kahn, Martine E.D. Chamuleau, Theresa M. Westers, Peter M. Van de Ven, Linda van Dreunen, Margot van Spronsen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht

Publikováno v: Haematologica, Vol 100, Iss 6 (2015)

Externí odkaz: https://doaj.org/article/47f3ad1d13a1469b9cfb93910ee30a3f

Regulatory T cells and progenitor B cells are independent prognostic predictors in lower risk myelodysplastic syndromes

Autor: Margot F. van Spronsen, Linda van Dreunen, Martine E.D. Chamuleau, Theresa M. Westers, Josephine D. Kahn, Peter M. van de Ven, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht

Publikováno v: Kahn, J D, Chamuleau, M E D, Westers, T M, van de Ven, P M, van Dreunen, L, van Spronsen, M F, Ossenkoppele, G J & van de Loosdrecht, A A 2015, ' Regulatory T cells and progenitor B cells are independent prognostic predictors in lower risk myelodysplastic syndromes ', Haematologica, vol. 100, no. 6, pp. E220-E222 . https://doi.org/10.3324/haematol.2014.116657
Haematologica, 100(6), E220-E222. Ferrata Storti Foundation

Research has provided evidence for immune surveillance in patients with myelodysplastic syndromes (MDS). However, while the presence of immune surveillance in MDS has been observed, little is known about its prognostic implications. This study aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab3111ae19ae69569793cd6772c303f
https://pubmed.ncbi.nlm.nih.gov/25749828

Multi-Dimensional Resistance Phenotype Allows Subpopulation of Quiescent Chronic Myeloid Leukemia Stem Cells to Universally Escape From Therapeutic Attack

Autor: J.H. Frederik Falkenburg, Renate S. Hagedoorn, Inge Jedema, Linda van Dreunen

Publikováno v: Blood. 116:203-203

Abstract 203 Chronic myeloid leukemia (CML) is well responsive to various therapeutic strategies, including conventional chemotherapy, tyrosine kinase inhibitors (TKI), but also allogeneic stem cell transplantation combined with donor lymphocyte infu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5915842b8069c38eb05a3f1513cde24a
https://doi.org/10.1182/blood.v116.21.203.203

High Expression of Decoy Receptor TRAIL-R3 on AML Blasts Is Associated to Shortened Overall Survival. TRAIL-R3 Induced Apoptosis Resistance Can Be Overcome by Specifically Targeting TRAIL-R2 in Vitro

Autor: Martine E.D. Chamuleau, Adri Zevenbergen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Linda van Dreunen, S.M.G. Jirka

Publikováno v: Blood. 112:2946-2946

In vivo, effector T cells and NK cells do express membrane-bound TRAIL (TNF-related apoptosis-inducing ligand). T cells also secrete a soluble form of TRAIL (sTRAIL). Binding of TRAIL to one of the receptors on target cells can induce apoptosis. In h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf01136556eba69e2036bc7fe3bbbf0e
https://doi.org/10.1182/blood.v112.11.2946.2946

T Cell Mediated Autologous Cytotoxicity Against Hematopoietic Precursor Cells in Low and Intermediate-1 Risk Myelodysplastic Syndrome

Autor: Martine E.D. Chamuleau, Adri Zevenbergen Ing, Theresia M. Westers Ing, Judith Groenland, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Corien Eeltink, Linda van Dreunen

Publikováno v: Blood. 110:4603-4603

The immune system plays a role in the pathogenesis of myelodysplastic syndrome (MDS) but its precise contribution to disease development and control is not fully clarified. T cell activation could reflect undesired autoimmune reactions against normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81e76f81477a102d6001afe327a88996
https://doi.org/10.1182/blood.v110.11.4603.4603