Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Linda Zukley"'
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Autor:
Roshni Roy, Pei-Lun Kuo, Julián Candia, Dimitra Sarantopoulou, Ceereena Ubaida-Mohien, Dena Hernandez, Mary Kaileh, Sampath Arepalli, Amit Singh, Arsun Bektas, Jaekwan Kim, Ann Z Moore, Toshiko Tanaka, Julia McKelvey, Linda Zukley, Cuong Nguyen, Tonya Wallace, Christopher Dunn, William Wood, Yulan Piao, Christopher Coletta, Supriyo De, Jyoti Sen, Nan-ping Weng, Ranjan Sen, Luigi Ferrucci
Publikováno v:
eLife, Vol 12 (2023)
Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and their relationships to gene regulation are unknown. We identified age-associated DNA methylat
Externí odkaz:
https://doaj.org/article/d686b4020d774313aa1c545d7788c07b
Autor:
Jian Lu, Raheel Ahmad, Thomas Nguyen, Jeffrey Cifello, Humza Hemani, Jiangyuan Li, Jinguo Chen, Siyi Li, Jing Wang, Achouak Achour, Joseph Chen, Meagan Colie, Ana Lustig, Christopher Dunn, Linda Zukley, Chee W. Chia, Irina Burd, Jun Zhu, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The characterisation of T cells during aging is important to predict functional outcomes in vaccination or infection. Here the authors use flow cytometry and scRNA sequencing to transcriptionally age CD8 T cells and then use a machine learning model
Externí odkaz:
https://doaj.org/article/06820e5848b3446782b42bbc3c749de7
Autor:
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age. However, the precise size of human TCR repertoires, in both total and subsets of T cells,
Externí odkaz:
https://doaj.org/article/be9e3fbb629f4693b28c5ccd2679bf6e
Autor:
Mustapha Bouhrara, Luis E. Cortina, Abinand C. Rejimon, Nikkita Khattar, Christopher Bergeron, Janet Bergeron, Denise Melvin, Linda Zukley, Richard G. Spencer
Publikováno v:
NeuroImage, Vol 206, Iss , Pp 116307- (2020)
Previous in-vivo magnetic resonance imaging (MRI)-based studies of age-related differences in the human brainstem have focused on volumetric morphometry. These investigations have provided pivotal insights into regional brainstem atrophy but have not
Externí odkaz:
https://doaj.org/article/a43e6da55dcc488f891affd8660adb97
Autor:
Toshiko Tanaka, Yuri Milaneschi, Yongqing Zhang, Kevin G Becker, Linda Zukley, Luigi Ferrucci
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181100 (2017)
Uric acid has been linked with increased risk of chronic disease such as cardiovascular disease and this association has been attributed to a pro-inflammatory effect. Indeed, observational studies have shown that high uric acid is associated with hig
Externí odkaz:
https://doaj.org/article/fa8651ab612048ff8cad09ae81dfcbc1
Autor:
Richard W. Kim, Yang An, Linda Zukley, Luigi Ferrucci, Theodora Mauro, Kristine Yaffe, Susan M. Resnick, Katrina Abuabara
Publikováno v:
Journal of Investigative Dermatology. 143:1085-1087
Autor:
Roshni Roy, Pei-Lun Kuo, Julián Candia, Dimitra Sarantopoulou, Ceereena Ubaida-Mohien, Dena Hernandez, Mary Kaileh, Sampath Arepalli, Amit Singh, Arsun Bektas, Jaekwan Kim, Ann Zenobia Moore, Toshiko Tanaka, Julia McKelvey, Linda Zukley, Cuong Nguyen, Tonya Wallace, Christopher Dunn, William Wood, Yulan Piao, Christopher Coletta, Supriyo De, Jyoti Misra Sen, Nan-ping Weng, Ranjan Sen, Luigi Ferrucci
Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and their relationships to gene regulation are unknown. We identified age-associated DNA methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48375812d9541b74e205fcd205a7d98f
https://doi.org/10.1101/2023.01.23.525162
https://doi.org/10.1101/2023.01.23.525162
Autor:
Luigi Ferrucci, Christopher M. Bergeron, Denise Melvin, Wenshu Qian, Richard W Kim, Linda Zukley, Mustapha Bouhrara, Nikkita Khattar, Richard G. Spencer, Susan M. Resnick
Publikováno v:
Human Brain Mapping
The g‐ratio, defined as the inner‐to‐outer diameter of a myelinated axon, is associated with the speed of nerve impulse conduction, and represents an index of axonal myelination and integrity. It has been shown to be a sensitive and specific bi
Autor:
Dimitrios Tsitsipatis, Jennifer L. Martindale, Ceereena Ubaida‐Mohien, Alexey Lyashkov, Hagai Yanai, Amogh Kashyap, Chang Hoon Shin, Allison B. Herman, Eunbyul Ji, Jen‐Hao Yang, Rachel Munk, Christopher Dunn, Yevgeniya Lukyanenko, Xiaoling Yang, Chee W. Chia, Ajoy C. Karikkineth, Linda Zukley, Jarod D’Agostino, Mary Kaileh, Chang‐Yi Cui, Isabel Beerman, Luigi Ferrucci, Myriam Gorospe
Publikováno v:
Aging Cell. 21
Changes in the proteome of different human tissues with advancing age are poorly characterized. Here, we studied the proteins present in primary skin fibroblasts collected from 82 healthy individuals across a wide age spectrum (22-89 years old) who p