Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

Autor: Monta Ustinova, Raitis Peculis, Raimonds Rescenko, Vita Rovite, Linda Zaharenko, Ilze Elbere, Laila Silamikele, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins

Publikováno v: BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)

Abstract Background Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of pa

Externí odkaz: https://doaj.org/article/eff6c95da64843748bc416c62dc2702e

Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues.

Autor: Darta Maija Zake, Janis Kurlovics, Linda Zaharenko, Vitalijs Komasilovs, Janis Klovins, Egils Stalidzans

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0249594 (2021)

Metformin is the primary drug for type 2 diabetes treatment and a promising candidate for other disease treatment. It has significant deviations between individuals in therapy efficiency and pharmacokinetics, leading to the administration of an unnec

Externí odkaz: https://doaj.org/article/98eb67c9f1444ced9df1ebcd33d1439e

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Autor: Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins

Publikováno v: Journal of Epidemiology, Vol 28, Iss 8, Pp 353-360 (2018)

Background: The Genome Database of the Latvian Population (LGDB) is a national biobank that collects, maintains, and processes health information, data, and biospecimens collected from representatives of the Latvian population. These specimens serve

Externí odkaz: https://doaj.org/article/2d4d7d7d329c4b729cba111b26292529

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.

Autor: Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0204317 (2018)

BACKGROUND:Metformin is a widely used first-line drug for treatment of type 2 diabetes. Despite its advantages, metformin has variable therapeutic effects, contraindications, and side effects. Here, for the very first time, we investigate the short-t

Externí odkaz: https://doaj.org/article/d75c41f66a154872b1b1fc0f2fa82b14

Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events

Autor: Sebastian Mate, Kaisa Silander, Lars Ebert, Michael Neumann, Barbara Parodi, Heimo Müller, Petr Holub, Philip R. Quinlan, Veronique T'Joen, Niina Eklund, Cäcilia Engels, Ny Haingo Andrianarisoa, Gabriele Anton, Erik P A Van Iperen, Linda Zaharenko, Joachim Geeraert, Roxana Merino-Martinez, Elodie Caboux, Hans Demski, Annelies Debucquoy, Esther van Enckevort, Rumyana Proynova

Publikováno v: Biopreservation and Biobanking
Biopreservation and biobanking, 18(3), 155-164. Mary Ann Liebert Inc.
Biopreservation and biobanking, 18(3), 155-164. MARY ANN LIEBERT, INC

Introduction: The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology to facilitate data sharing in biobanks and sample collections. The MIABIS Core terminology consists of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec995d09a4b0c86b30d280ff6985de5
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