Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Linda Z. Penn"'
Autor:
Diandra Zipinotti dos Santos, Mohamad Elbaz, Emily Branchard, Wiebke Schormann, Carla E. Brown, Autumn R. Meek, Vincent C.O. Njar, Robert J. Hamilton, Mark A. Reed, David W. Andrews, Linda Z. Penn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116934- (2024)
There is an urgent need to provide immediate and effective options for the treatment of prostate cancer (PCa) to prevent progression to lethal castration-resistant PCa (CRPC). The mevalonate (MVA) pathway is dysregulated in PCa, and statin drugs comm
Externí odkaz:
https://doaj.org/article/699af22ca7604478ae0e47c46ba49ef6
Autor:
Jenna E. van Leeuwen, Wail Ba-Alawi, Emily Branchard, Jennifer Cruickshank, Wiebke Schormann, Joseph Longo, Jennifer Silvester, Peter L. Gross, David W. Andrews, David W. Cescon, Benjamin Haibe-Kains, Linda Z. Penn, Deena M. A. Gendoo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Statins are promising for breast cancer therapy; dipyridamole can potentiate their effects, but is contraindicated in some cases. Here, the authors develop a pharmacogenomics pipeline to predict other compounds that potentiate statins, and validate t
Externí odkaz:
https://doaj.org/article/f57984f909454f0787ee786ab65589d9
Autor:
Joseph Longo, Aleksandra A. Pandyra, Paweł Stachura, Mark D. Minden, Aaron D. Schimmer, Linda Z. Penn
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2533-2545 (2020)
Dipyridamole, an antiplatelet drug, has been shown to synergize with statins to induce cancer cell‐specific apoptosis. However, given the polypharmacology of dipyridamole, the mechanism by which it potentiates statin‐induced apoptosis remains unc
Externí odkaz:
https://doaj.org/article/cc9d4a89ea4c476590915dbcbbfed969
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
Joseph Longo, Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Mehdi Masoomian, Dixon T.S. Woon, Yuzhuo Wang, Eric X. Chen, Robert J. Hamilton, Joan M. Sweet, Theodorus H. van der Kwast, Neil E. Fleshner, Linda Z. Penn
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 119-130 (2019)
Objective: The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that statin
Externí odkaz:
https://doaj.org/article/f03d8eaff63e4e4990bc23cc62eb3734
Autor:
Dharmendra Dingar, William B. Tu, Diana Resetca, Corey Lourenco, Aaliya Tamachi, Jason De Melo, Kathleen E. Houlahan, Manpreet Kalkat, Pak-Kei Chan, Paul C. Boutros, Brian Raught, Linda Z. Penn
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.
Externí odkaz:
https://doaj.org/article/cc8066c5d0d249efbc4b69b3a8efd7c8
Autor:
Corey Lourenco, Manpreet Kalkat, Kathleen E. Houlahan, Jason De Melo, Joseph Longo, Susan J. Done, Paul C. Boutros, Linda Z. Penn
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an in vivo model t
Externí odkaz:
https://doaj.org/article/5c53bfc6b9444697a49291e7deac9981
Autor:
Pak-Kei Chan, Tharan Srikumar, Dharmendra Dingar, Manpreet Kalkat, Linda Z. Penn, Brian Raught
Publikováno v:
Data in Brief, Vol 1, Iss C, Pp 76-78 (2014)
BioID was performed using FlagBirA⁎ (the R118G biotin ligase mutant protein) and FlagBirA⁎-Myc in HEK293 T-REx cells maintained both under standard cell culture conditions and as mouse xenografts. The mass spectrometry dataset acquired in this st
Externí odkaz:
https://doaj.org/article/3ee5430f45cf41c8b7fe0315e0de2dd3
Autor:
Jim Dimitroulakos, Wilson H. Marhin, Jason Tokunaga, Jonathan Irish, Patrick Gullane, Linda Z. Penn, Suzanne Kamel-Reid
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 4, Pp 337-346 (2002)
We recently identified 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme of the mevalonate pathway, as a potential therapeutic target of the head and neck squamous cell carcinomas (HNSCC) and cervical carcinomas (CC)
Externí odkaz:
https://doaj.org/article/218bc8c7768245dd8df65f799111361b
Publikováno v:
Prostate Cancer and Prostatic Diseases. 25:650-656