Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Linda Yingqi Lin"'
Autor:
Linda Yingqi Lin, Sawyer McCarthy, Barrett M Powell, Yanti Manurung, Irene M Xiang, William L Dean, Brad Chaires, Liliya A Yatsunyk
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241513 (2020)
The G-quadruplex (GQ) is a well-studied non-canonical DNA structure formed by G-rich sequences found at telomeres and gene promoters. Biological studies suggest that GQs may play roles in regulating gene expression, DNA replication, and DNA repair. S
Externí odkaz:
https://doaj.org/article/b8f62c4f1d994fcba36b57c1a1bab62f
Autor:
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A. Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q. Tsai, Myriam Armant, Scot A. Wolfe, Rosalba Giugno, Daniel E. Bauer, Luca Pinello
Publikováno v:
Nat Genet
CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat disease. However, standard computational and biochemical methods to predict off-target potential focus on reference genomes. We developed an efficient tool call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6955ae43d77107bdfe1de09e8c63a
https://hdl.handle.net/11562/1080767
https://hdl.handle.net/11562/1080767
Autor:
Jing Zeng, My Anh Nguyen, Marioara-Felicia Ciuculescu, Esther Mintzer, Pengpeng Liu, Linda Yingqi Lin, Tolulope O Rosanwo, Archana Verma, Nola Neri, Stacy A. Maitland, Alden Richter, David G. Justus, Kendell Clement, Christian Brendel, Luca Pinello, John P Manis, Myriam Armant, Scot A. Wolfe, Daniel E. Bauer
Publikováno v:
Blood. 140:10671-10672
Publikováno v:
Journal of porphyrins and phthalocyanines
N-methyl mesoporphyrin IX (NMM) is a water-soluble, non-symmetric porphyrin with excellent optical properties and unparalleled selectivity for G-quadruplex (GQ) DNA. G-quadruplexes are non-canonical DNA structures formed by guanine-rich sequences. Th
Autor:
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A. Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q. Tsai, Myriam Armant, Scot A. Wolfe, Rosalba Giugno, Daniel E. Bauer, Luca Pinello
Publikováno v:
Università degli Studi di Verona-IRIS
CRISPR gene editing holds great promise to modify somatic genomes to ameliorate disease. In silico prediction of homologous sites coupled with biochemical evaluation of possible genomic off-targets may predict genotoxicity risk of individual gene edi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6939987b389bedb32c22997633b0d03
https://doi.org/10.1101/2021.05.20.445054
https://doi.org/10.1101/2021.05.20.445054
Autor:
Christopher Chung, Ronen Marmorstein, Naomi Bronkema, Twan W Sia, YongJoon Shin, Daniel J Boehlmer, Diep Nguyen, Emily Kibby, Jeffrey O. Zhou, Ming-Ray Xu, Rajiv Potluri, Linda Yingqi Lin, Narine Vapuryan, Michael Grasso, Daniela Fera, Tiara Tillis, Caroline Burkhard, Shirley H Zeng, Elizabeth Erler, Lucila A. Acevedo
Publikováno v:
Biochemistry
In the MAPK pathway, an oncogenic V600E mutation in B-Raf kinase causes the enzyme to be constitutively active, leading to aberrantly high phosphorylation levels of its downstream effectors, MEK and ERK kinases. The V600E mutation in B-Raf accounts f
Autor:
Ming-Ray Xu, YongJoon Shin, Caroline Burkhard, Daniela Fera, Lucila A. Acevedo, Rajiv Potluri, Narine Vapuryan, Twan Sia, Naomi Bronkema, Shirley H Zeng, Linda Yingqi Lin, Jeffrey O. Zhou, Michael Grasso, Ronen Marmorstein, Diep Nguyen, Daniel J Boehlmer, Christopher Chung, Emily Kibby, Tiara Tillis, Elizabeth Erler
In the MAPK pathway, an oncogenic V600E mutation in B-Raf kinase causes the enzyme to be constitutively active, leading to aberrantly high phosphorylation levels of its downstream effectors, MEK and ERK kinases. The V600E mutation in B-Raf accounts f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c45fefe86f4aabf3ee95ce5f6229fe8
https://doi.org/10.1101/2020.07.19.211177
https://doi.org/10.1101/2020.07.19.211177
Autor:
Aurore Guédin, Liliya A. Yatsunyk, Samir Armane, Linda Yingqi Lin, Jean-Louis Mergny, Stéphane Thore, Laurent Lacroix
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2018, 46 (10), pp.5297-5307. ⟨10.1093/nar/gky290⟩
'Nucleic Acids Research ', vol: 46, pages: 5297-5307 (2018)
Nucleic Acids Research, Oxford University Press, 2018, 46 (10), pp.5297-5307. ⟨10.1093/nar/gky290⟩
'Nucleic Acids Research ', vol: 46, pages: 5297-5307 (2018)
Guanine-rich DNA has the potential to fold into non-canonical G-quadruplex (G4) structures. Analysis of the genome of the social amoeba Dictyostelium discoideum indicates a low number of sequences with G4-forming potential (249–1055). Therefore, D.
Autor:
Myriam Armant, Selami Demirci, David R. Williams, Amornrat Tangprasittipap, Stacy Maitland, Pengpeng Liu, Daniel E. Bauer, J. Keith Joung, Karl Petri, Danilo Pellin, Jing Zeng, John F. Tisdale, Linda Yingqi Lin, John P. Manis, Kevin Luk, Daniela Abriss, Scot A. Wolfe, Yuxuan Wu, Christian Brendel, Shengdar Q. Tsai, Luca Pinello, Varun Katta, Jonathan Y. Hsu, Chokdee Vong, Robert E. Donahue, Shondra M. Pruett-Miller, My Anh Nguyen, Khaled Essawi, Naoya Uchida, Duantida Songdej, Shaina N. Porter, Vikram Pattanayak, Suradej Hongeng, Marioara-Felicia Ciuculescu, Esther Mintzer
Publikováno v:
Blood. 138:1852-1852
Targeting the BCL11A erythroid enhancer by gene editing is a promising approach to fetal hemoglobin induction for beta-hemoglobinopathies. HbF levels vary widely among individuals, suggesting potential heterogeneity in HbF responses after therapeutic