Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Linda Wiens"'
Autor:
Qinghua Feng, Nancy B. Kiviat, Stephen E. Hawes, Hubert Vesselle, Janet S. Rasey, Linda Wiens, Joshua E. Stern, Hiep Lu
Publikováno v:
Lung Cancer. 69:172-179
Background: We previously identified a number of genes which were methylated significantly more frequently in the tumor compared to the non-cancerous lung tissues from non-small cell lung cancer (NSCLC) patients. Detection of methylation profiles of
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 29:49-54
An investigation was conducted to determine if the 5-fluoro analog of TPI (5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]uracil), a potent inhibitor of human thymidine phosphorylase (TP), has an IC(50) in a range that might allow to use it labeled for i
Publikováno v:
Journal of the American Dietetic Association. 110:101-105
Measuring the outcomes of nutrition interventions in health promotion settings can be a challenge. Nutrition screening tools are often used to measure dietary patterns and nutrition intervention outcomes, but these tools may lack quantitative scoring
Autor:
Joshua E. Stern, Linda Wiens, Hubert Vesselle, Stephen E. Hawes, Janet S. Rasey, Janice Morihara, J. Scott Brockenbrough, Qinghua Feng
Publikováno v:
Journal of Histochemistry & Cytochemistry. 57:1087-1097
The thymidine salvage pathway enzymes thymidine kinase 1 (TK1) and thymidine phosphorylase (TP) compete for thymidine as a substrate and catalyze opposing synthetic and catabolic reactions that have been implicated in the control of proliferation and
Autor:
Eric Turcotte, Eric Vallières, Linda Wiens, Alexander Salskov, Douglas E. Wood, Hubert Vesselle, C. Diana Jordan, Rodney A. Schmidt
Publikováno v:
Journal of Thoracic Oncology. 3(9):971-978
Introduction We compared primary non-small cell lung cancer (NSCLC) 18 F-fluorodeoxyglucose (FDG) uptake at positron emission tomography (PET) to tumor histologic features and Ki-67 proliferation index. This large, prospectively-recruited patient coh
Autor:
Hubert Vesselle, Hiep Lu, Zhao Ming Dong, C. Diana Jordan, Linda Wiens, Qinghua Feng, Nancy B. Kiviat, Stephen E. Hawes, Joshua E. Stern
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 17:645-654
We used MethyLight assays to analyze DNA methylation status of 27 genes on 49 paired cancerous and noncancerous tissue samples from non-small cell lung cancer (NSCLC) patients who underwent surgical resection. Seven genes (RARB, BVES, CDKN2A, KCNH5,
Publikováno v:
Nuclear Medicine and Biology. 34:619-623
Introduction The activity of the pyrimidine salvage pathway enzyme thymidine kinase 1 (TK1) is tightly cell cycle regulated and has been investigated as a prognostic indicator of cancer in a variety of tissues. However, using the in vitro assay of TK
Autor:
Hubert Vesselle, Linda Wiens, Janet S. Rasey, Schwartz Jl, John R. Grierson, J. Scott Brockenbrough, Robert Jordan
Publikováno v:
Nuclear Medicine and Biology. 34:471-478
Two human cell lines (A549 and U937) with cytosolic thymidine phosphorylase (TP) activity were used to evaluate the potential of 5′-deoxy-5′-[F-18]fluorothymidine ([F-18]DFT) as a tracer of intracellular TP expression. Cellular metabolism of DFT
Autor:
Stephen E. Hawes, Joshua E. Stern, Douglas E. Wood, Joseph D. Freeman, Huang Q. Nguyen, Eric Vallières, Alexander Salskov, Linda Wiens, Hubert Vesselle, Philip Bastian
Publikováno v:
Clinical Cancer Research. 13:3255-3263
Purpose: This prospective study evaluated the prognostic significance of 18F-fluorodeoxyglucose (18F-FDG) uptake in primary non-small cell lung cancer (NSCLC) at positron emission tomography, in a carefully staged population, while correcting for par
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:679-682
A prototype blood plasma processor unit was designed and tested for generic PET-tracer metabolite analyses, using solid-phase-extraction cartridges (SepPaks). An assay method for FLT (3′-deoxy-3′-[F-18]fluorothymidine) and its blood metabolite: F