Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Linda V. Sinclair"'
Autor:
Leonard R. Pelgrom, Gavin M. Davis, Simon O’Shaughnessy, Emilie J.M. Wezenberg, Sander I. Van Kasteren, David K. Finlay, Linda V. Sinclair
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112828- (2023)
Summary: System-level analysis of single-cell data is rapidly transforming the field of immunometabolism. Given the competitive demand for nutrients in immune microenvironments, there is a need to understand how and when immune cells access these nut
Externí odkaz:
https://doaj.org/article/f8ed02eb6f6c4fc3b2176333693c7e6f
Autor:
Molly S. George, Jenifer Sanchez, Christina Rollings, David Fear, Peter Irving, Linda V. Sinclair, Anna Schurich
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107280- (2023)
Summary: Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T cell activation is associated with disease severity and may be implicated in producing long-covid symptoms. Here, we assess the role of extracellular ve
Externí odkaz:
https://doaj.org/article/9b2cfbbd5b5749df90f2b4881f8ed95b
Publikováno v:
eLife, Vol 9 (2020)
T cell expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in murine T
Externí odkaz:
https://doaj.org/article/b51ad7a23b004636a05c6f62c3b477ca
Autor:
Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expressi
Externí odkaz:
https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Kynurenine is an immunomodulatory aryl hydrocarbon receptor (AHR) ligand. Here the authors show, using a new flow cytometry based method, that kynurenine needs to be transported across the plasma membrane of activated T cells by the transporter prote
Externí odkaz:
https://doaj.org/article/d860c1c2a7b44c229d50bae26faa0f86
Autor:
Benjamin J. Jenkins, Julianna Blagih, Fernando M. Ponce-Garcia, Mary Canavan, Nancy Gudgeon, Simon Eastham, David Hill, Megan M. Hanlon, Eric H. Ma, Emma L. Bishop, April Rees, James G. Cronin, Elizabeth C. Jury, Sarah K. Dimeloe, Douglas J. Veale, Catherine A. Thornton, Karen H. Vousden, David K. Finlay, Ursula Fearon, Gareth W. Jones, Linda V. Sinclair, Emma E. Vincent, Nicholas Jones
Publikováno v:
Cell Metabolism.
Autor:
Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their micr
Externí odkaz:
https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d6002
Autor:
Linda V Sinclair, Andrew JM Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Publikováno v:
eLife, Vol 8 (2019)
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution mass spect
Externí odkaz:
https://doaj.org/article/7d4cdb633ab44514a668ee05c272cae5
Autor:
Nidhi Kedia-Mehta, Marta M. Pisarska, Christina Rollings, Chloe O’Neill, Conor De Barra, Cathriona Foley, Nicole A. W. Wood, Neil Wrigley-Kelly, Natacha Veerapen, Gurdyal Besra, Ronan Bergin, Nicholas Jones, Donal O’Shea, Linda V. Sinclair, Andrew E. Hogan
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate T cells that recognize bacterial ligands and play a key role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells undergo proliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71306b3d72d96f9b4cb02d51fc6dc1fc
https://cronfa.swan.ac.uk/Record/cronfa63256
https://cronfa.swan.ac.uk/Record/cronfa63256
Autor:
Féaron C. Cassidy, Nidhi Kedia-Mehta, Ronan Bergin, Andrea Woodcock, Ardena Berisha, Ben M. Bradley, Eva Booth, Odhran K. Ryan, Linda V. Sinclair, Donal O’Shea, Andrew E. Hogan
Mucosal Associated Invariant T (MAIT) cells are a subset of unconventional T cells, which recognise a limited repertoire of ligands presented by the MHC class I-like molecule MR1. In addition to their key role in host protection against bacterial and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ab0b61713dc617c83f1b28fb021e28
https://doi.org/10.1101/2022.12.20.521164
https://doi.org/10.1101/2022.12.20.521164