Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Linda T. Vo"'
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101610- (2022)
Background: Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic insulin-producing β cells are specifically destroyed by the immune system. Understanding the initiation and progression of human T1D has been hampered by the lack of appr
Externí odkaz:
https://doaj.org/article/56bcad7a7f4a40dda6f7d215d879fca9
Autor:
Mauricio Cortes, Michael J. Chen, David L. Stachura, Sarah Y. Liu, Wanda Kwan, Francis Wright, Linda T. Vo, Lindsay N. Theodore, Virginie Esain, Isaura M. Frost, Thorsten M. Schlaeger, Wolfram Goessling, George Q. Daley, Trista E. North
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 458-468 (2016)
Vitamin D insufficiency is a worldwide epidemic affecting billions of individuals, including pregnant women and children. Despite its high incidence, the impact of active vitamin D3 (1,25(OH)D3) on embryonic development beyond osteo-regulation remain
Externí odkaz:
https://doaj.org/article/c86ac4467ef9412db3c1c7c808d28080
Autor:
Elizabeth C. Stahl, Jennifer K. Sabo, Min Hyung Kang, Ryan Allen, Elizabeth Applegate, Shin Eui Kim, Yoonjin Kwon, Anmol Seth, Nicholas Lemus, Viviana Salinas-Rios, Katarzyna Soczek, Marena Trinidad, Linda T. Vo, Chris Jeans, Anna Wozniak, Timothy Morris, Athen Kimberlin, Thomas Foti, David F. Savage, Jennifer A. Doudna
Transient delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) into the central nervous system (CNS) for therapeutic genome editing could avoid limitations of viral vector-based delivery including cargo capacity, immunogenicity, and cost. Here we tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f4275a42165337bdc6ac4459130f9b
https://doi.org/10.1101/2023.04.13.536294
https://doi.org/10.1101/2023.04.13.536294
Autor:
Areum Han, Trista E. North, Nathaniel K. Mullin, Patricia Sousa, Edroaldo Lummertz da Rocha, Leonard I. Zon, Yuqi Tan, Thorsten M. Schlaeger, George Q. Daley, Samuel Landry, Patrick Cahan, Song Yang, Linda T. Vo, Yi Zhou, Yi Fen Lu, Deepak Kumar Jha, Minh Nguyen, Michael J. Chen, Caroline Kubaczka, Phoebe Hunter, Yuko Fujiwara
Publikováno v:
Stem Cell Reports
Summary Studies of hematopoietic stem cell (HSC) development from pre-HSC-producing hemogenic endothelial cells (HECs) are hampered by the rarity of these cells and the presence of other cell types with overlapping marker expression profiles. We gene
Autor:
Linda T. Vo, P. Jonathan Li, Theodore L. Roth, Murad R. Mamedov, David N. Nguyen, Peixin Amy Chen, Eric Shifrut, Jeffrey A. Bluestone, Ryan Apathy, Alexander Marson, Francis C. Szoka, Jennifer M. Puck, Daniel B. Goodman, Victoria Tobin
Publikováno v:
Nature biotechnology
Nature biotechnology, vol 38, iss 1
Nature biotechnology, vol 38, iss 1
Versatile and precise genome modifications are needed to create a wider range of adoptive cellular therapies1-5. Here we report two improvements that increase the efficiency of CRISPR-Cas9-based genome editing in clinically relevant primary cell type
Autor:
Natasha L. Rudy, Anna C.E. Hurst, Alexander Marson, Steven H. Kroft, James Garifallou, Sarah K. Nicholas, Piyush Pillarisetti, Gerald Wertheim, Di Sun, Andrew D. Wells, Titus J. Boggon, Gregory M.K. Poon, Kelly Maurer, Brian Nolan, Caroline Khanna, Francis Wright, Jennifer M. Puck, Struan F.A. Grant, Suela Xhani, Amy Rymaszewski, Ivan K. Chinn, Viktoria Zakharova, Samuel Yoon, James W. Verbsky, Neil Romberg, David N. Nguyen, Linda T. Vo, Kathleen E. Sullivan, Chun Su, Anna Shcherbina, Alix E. Seif, T. Prescott Atkinson, Amy L. Stiegler, Hakon Hakonarson, Anna Mukhina, Amanda V. Albrecht, Timothy S. Olson, Peixin Amy Chen, John M. Routes, Benjamin Demaree, Joud Hajjar, James R. Lupski, Adam R. Abate, Michael Gonzalez, Carole Le Coz
Publikováno v:
Journal of Experimental Medicine. 218
The pioneer transcription factor (TF) PU.1 controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible genomic sites. PU.1 deficiency fatally arrests lymphopoiesis and myelopo
Autor:
Benjamin L. Ebert, Johan Flygare, Kavitha Siva, Yi Zhou, Jessica M. Humphries, Leonard I. Zon, Megan C. Blair, Linda T. Vo, Alison M. Taylor, Arish N Shah, Katherine E. McGrath, Vijay G. Sankaran, Emma Stillman, Sergei Doulatov, David M. Raiser, Iris T. Chan, George Q. Daley, Anindita Basak, Elizabeth R. Macari, Eliezer Calo, Richard I. Gregory, Blanche P. Alter, Mehdi Pirouz
Publikováno v:
PMC
Sci Transl Med
Sci Transl Med
© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works Diamond-Blackfan anemia (DBA) is a rare hematopoietic disease characterized by a block in re
Publikováno v:
Nature reviews. Immunology, vol 20, iss 3
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells and describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8b0bbb8e3abb546105cb583ff0cf8c
https://escholarship.org/uc/item/3n88v6vm
https://escholarship.org/uc/item/3n88v6vm
Autor:
Zhen Shao, Patricia Sousa, Linda T. Vo, Trista E. North, George Q. Daley, Stuart H. Orkin, Jessica Barragan, Deepak Kumar Jha, Sergei Doulatov, Melissa A. Kinney, Yuannyu Zhang, Areum Han, Jian Xu, Marcella Cesana, Xin Liu
Publikováno v:
Nature. 553:506-510
All haematopoietic cell lineages that circulate in the blood of adult mammals derive from multipotent haematopoietic stem cells (HSCs). By contrast, in the blood of mammalian embryos, lineage-restricted progenitors arise first, independently of HSCs,
Publikováno v:
Nat Rev Immunol
Cellular therapies using regulatory T (T(reg)) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of T(reg) cells and des