Výsledky vyhledávání - "Linda T. Hamel"

Novel and Potent Adenosine 3',5'-Cyclic Phosphate Phosphodiesterase III Inhibitors: Thiazolo[4,5-b][1,6]naphthyridin-2-ones

Autor: Mary J. Connell, Baldev Singh, Paul J. Silver, Ross G. Bentley, Patrick O. Pennock, Bacon Edward R, Donald C. Bode, Linda T. Hamel, Edward D. Pagani, George Y. Lesher, Shaughnessy Robinson

Publikováno v: Journal of Medicinal Chemistry. 38:2546-2550

The transformation of 3-bromo-1,6-naphthyridin-2(1H)-ones 8 to thiazolo[4,5-b][1,6]naphthyridin-2(1H)-ones 12 resulted in a 2-9-fold increase in cAMP phosphodiesterase (PDE) III inhibitory potency. Unlike the secondary binding sites on the cAMP PDE I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0df44ef65199d17082254078017dbb
https://doi.org/10.1021/jm00014a007

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Inhibition of cardiovascular low-Km cAMP phosphodiesterase activity by medorinone

Autor: Mary J. Connell, Edward D. Pagani, Paul J. Silver, Bernard O'Connor, Linda T. Hamel, Kathleen Dillon, Ross G. Bentley, Richard A. Ferrari

Publikováno v: Drug Development Research. 21:93-104

Medorinone (5-methyl-1, 6-naphthyridin-2(1H)-one) is a structurally novel cardiotonic/vasodilator agent. The purpose of the present study was to evaluate the effects of medorinone on subcellular systems involved in the contractile-relaxation processe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac94cc2d8ece2665af19397d18c41f0b
https://doi.org/10.1002/ddr.430210203

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Phosphodiesterase Isozyme Inhibition, Activation of the cAMP System, and Positive Inotropy Mediated by Milrinone in Isolated Guinea Pig Cardiac Muscle

Autor: Paul J. Silver, Alex L. Harris, Paul C. Canniff, Rhonda E. Lepore, Ross G. Bentley, Linda T. Hamel, Dale B. Evans

Publikováno v: Journal of Cardiovascular Pharmacology. 13:530-540

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::956f804452fbd62740e8e4a4d19bd9e1
https://doi.org/10.1097/00005344-198913040-00004

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Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle

Autor: Cynthia R. Bushover, Dale B. Evans, Ross G. Bentley, M H Perrone, Linda T. Hamel, Paul J. Silver

Publikováno v: European Journal of Pharmacology. 150:85-94

Phosphodiesterase isozymes were isolated by diethylaminoethyl ether (DEAE) column chromatography from cardiac muscle (canine, guinea pig), vascular (canine and guinea pig aortic) and airway (canine tracheal) smooth muscle. All peak I phosphodiesteras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332a5e2196b51736e25408d94cffda93
https://doi.org/10.1016/0014-2999(88)90753-4

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The effects of serotonin antagonists in a behavioral despair procedure in mice

Autor: Daniel Luttinger, M H Perrone, Marcia Freedman, Susan J. Ward, Linda T. Hamel

Publikováno v: European journal of pharmacology. 107(1)

Six serotonin antagonists (pizotifen, mianserin, cyproheptadine, ketanserin, trazodone and methysergide) were tested in mice in a behavioral despair procedure. The behavioral despair procedure detects most antidepressant compounds. Pizotifen, mianser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e471d3a2d9f94ad1935d8cb0f84bcd7a
https://pubmed.ncbi.nlm.nih.gov/6526071

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