Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease

Autor: Stefan Bartl, Abid Oueslati, Amber L. Southwell, Alberto Siddu, Michela Parth, Linda Suzanne David, Alexander Maxan, Nina Salhat, Markus Burkert, Andreas Mairhofer, Theresa Friedrich, Halyna Pankevych, Katja Balazs, Guenther Staffler, Michael R. Hayden, Francesca Cicchetti, Oskar W. Smrzka

Publikováno v: Neurobiology of Disease, Vol 141, Iss , Pp 104943- (2020)

Huntington's disease (HD) is caused by a highly polymorphic CAG trinucleotide expansion in the gene encoding for the huntingtin protein (HTT). The resulting mutant huntingtin protein (mutHTT) is ubiquitously expressed but also exhibits the ability to

Externí odkaz: https://doaj.org/article/7a2a9cc730a442b79298549f98f442c9

Antibody-based therapies for Huntington’s disease: current status and future directions

Autor: Francesca Cicchetti, Hélèna L Denis, Linda Suzanne David

Publikováno v: Neurobiology of Disease, Vol 132, Iss, Pp-(2019)

The types of treatments and interventions being developed for chronic neurodegenerative disorders have expanded considerably in recent years. In addition to the variety of targets being pursued, strategies have moved from symptom management to more d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4419ce1296de886c0e89b7c9ac4d8786
http://www.sciencedirect.com/science/article/pii/S0969996119302372

Target-specific alterations in the VIP inhibitory drive to hippocampal GABAergic cells after status epilepticus

Autor: Lisa Topolnik, Linda Suzanne David

Publikováno v: Experimental Neurology. 292:102-112

Status epilepticus (SE) is associated with complex reorganization of hippocampal circuits involving a significant loss of specific subtypes of GABAergic interneurons. While adaptive circuit plasticity may increase the chances for recruitment of survi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbca3a57b435e6ca9e2b4cbc36274206
https://doi.org/10.1016/j.expneurol.2017.03.007

Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

Autor: Luc Bousset, Maria Masnata, Martine Saint-Pierre, Hélèna L Denis, Alexander Maxan, Jeffrey H. Kordower, Giacomo Sciacca, Florian Lauruol, Ronald Melki, Francesca Cicchetti, Melanie Alpaugh, Linda Suzanne David

Publikováno v: Acta Neuropathologica
Acta Neuropathologica, 2019, 137 (6), pp.981-1001. ⟨10.1007/s00401-019-01973-6⟩
Acta Neuropathologica, Springer Verlag, 2019, 137 (6), pp.981-1001. ⟨10.1007/s00401-019-01973-6⟩

In recent years, evidence has accumulated to suggest that mutant huntingtin protein (mHTT) can spread into healthy tissue in a prion-like fashion. This theory, however, remains controversial. To fully address this concept and to understand the possib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9014a0f58c4616e38cd4eacf83fbf9
https://cea.hal.science/cea-02279743

Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication

Autor: Xiuqing Chen, Francesca Cicchetti, Melanie Alpaugh, Martine Saint-Pierre, Nadine Lauinger, Alberto Siddu, Thomas M. Durcan, Linda Suzanne David

Publikováno v: Neurobiology of Disease, Vol 145, Iss, Pp 105042-(2020)

A number of publications have reported that cysteamine has significant therapeutic effects on several aspects of Parkinson's disease (PD)-related pathology but none of these studies have evaluated its impact on pathological forms of α-Synuclein (α-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e68fe9a39980fa9c226439908d054dc
https://doi.org/10.1016/j.nbd.2020.105042