Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Autor: Linda Spiegelberg, Ruud Houben, Raymon Niemans, Dirk de Ruysscher, Ala Yaromina, Jan Theys, Christopher P. Guise, Jeffrey B. Smaill, Adam V. Patterson, Philippe Lambin, Ludwig J. Dubois

Publikováno v: Clinical and Translational Radiation Oncology, Vol 15, Iss , Pp 62-69 (2019)

Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II results, the

Externí odkaz: https://doaj.org/article/75c6748e20a543519df6ae43fdf0f2f0

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Autor: Jeffrey Bruce Smaill, Raymon Niemans, Ala Yaromina, Philippe Lambin, Dirk De Ruysscher, Linda Spiegelberg, Adam V. Patterson, Ludwig Dubois, Jan Theys, Ruud Houben, Christopher P. Guise

Publikováno v: Clinical and Translational Radiation Oncology, Vol 15, Iss, Pp 62-69 (2019)
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, 15, 62-69. Elsevier Ireland Ltd

Highlights • Hypoxia-activated prodrugs have yielded promising results up to phase II trials. • Implementation of hypoxia-activated prodrugs in the clinic has not been successful. • Phase III clinical trials lack patient stratification based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dacf3137eb7d12771893eb800a6171
http://www.sciencedirect.com/science/article/pii/S2405630818301101

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Autor: Ana Vaniqui, Marc Vooijs, Ala Yaromina, Natasja G. Lieuwes, Lotte E J R Schyns, Frank Verhaegen, Venus Sosa Iglesias, Arjan J. Groot, Stefan J. van Hoof, Linda Spiegelberg, Ludwig Dubois, Jan Theys

Publikováno v: British Journal of Radiology, 92(1095):20180476. British Institute of Radiology

Objective: Lung cancer is the deadliest cancer worldwide. To increase treatment potential for lung cancer, pre-clinical models that allow testing and follow up of clinically relevant treatment modalities are essential. Therefore, we developed a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f02d6d60a4454c3cd92706bb861cc3
https://pubmed.ncbi.nlm.nih.gov/30465693

Optical Imaging of Tumor Response to Hyperbaric Oxygen Treatment and Irradiation in an Orthotopic Mouse Model of Head and Neck Squamous Cell Carcinoma

Autor: Senada Koljenović, Joanna A. M. Braks, Stijn Keereweer, Jeroen Essers, Yanto Ridwan, Eppo B. Wolvius, Roland Kanaar, Linda Spiegelberg

Publikováno v: Molecular Imaging and Biology
Molecular Imaging and Biology, 17(5), 633-642. Springer New York

Purpose Hyperbaric oxygen therapy (HBOT) is used in the treatment of radiation-induced tissue injury but its effect on (residual) tumor tissue is indistinct and therefore investigated in this study. Procedures Orthotopic FaDu tumors were established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ad7ca02bb2241c86af6d12e23ee465
https://doi.org/10.1007/s11307-015-0834-8

Effects of hyperbaric oxygen therapy on the viability of irradiated soft head and neck tissues in mice

Autor: Kgh van der Wal, U.M. Djasim, Eppo B. Wolvius, Jam Braks, Linda Spiegelberg, E Farrell

Publikováno v: Oral Diseases, 20(3), e111-e119. Wiley-Blackwell

Objectives Hyperbaric oxygen therapy (HBOT) is used clinically in irradiation-induced injury to healthy tissues, but the effectiveness and working mechanism remain unclear. This study examined the effects of HBOT on irradiated salivary glands and ton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850da1ff13db122c89d178743f5c62a1
https://doi.org/10.1111/odi.12162