Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Linda Sher"'
Autor:
Brittany Rocque, Kate Guion, Pranay Singh, Sarah Bangerth, Lauren Pickard, Jashdeep Bhattacharjee, Sofia Eguizabal, Carly Weaver, Shefali Chopra, Shengmei Zhou, Rohit Kohli, Linda Sher, Omid Akbari, Burcin Ekser, Juliet A. Emamaullee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Single cell and spatially resolved ‘omic’ techniques have enabled deep characterization of clinical pathologies that remain poorly understood, providing unprecedented insights into molecular mechanisms of disease. However, transcriptomic
Externí odkaz:
https://doaj.org/article/69a27fde78154e59acb5479cfb391793
Autor:
Sonal Sinha, Satoka Aizawa, Yasuhiro Nakano, Alexander Rialdi, Hye Yeon Choi, Rajan Shrestha, Stephanie Q. Pan, Yibu Chen, Meng Li, Audrey Kapelanski-Lamoureux, Gregory Yochum, Linda Sher, Satdarshan Paul Monga, Anthoula Lazaris, Keigo Machida, Michael Karin, Ernesto Guccione, Hidekazu Tsukamoto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatocellular carcinoma (HCC) is the 3rd most deadly malignancy. Activated hepatic stellate cells (aHSC) give rise to cancer-associated fibroblasts in HCC and are considered a potential therapeutic target. Here we report that selective abla
Externí odkaz:
https://doaj.org/article/6713daa54c2940a6b1e1813574aeb767
Autor:
Chad Nakagawa, Manjunatha Kadlera Nagaraj, Juan Carlos Hernandez, Dinesh Babu Uthay Kumar, Vivek Shukla, Risa Machida, Jörg Schüttrumpf, Linda Sher, Patrizia Farci, Lopa Mishra, Stanley M. Tahara, Jing-Hsiung James Ou, Keigo Machida
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTumor-initiating cells (TICs) are rare, stem-like, and highly malignant. Although intravenous hepatitis B and C immunoglobulins have been used for HBV and HCV neutralization in patients, their tumor-inhibitory effects have not yet been ex
Externí odkaz:
https://doaj.org/article/c8d34736f6a64b2da84b7839e34d25e1
Autor:
Juan Carlos Hernandez, Da‐Wei Yeh, Joel Marh, Hye Yeon Choi, Julia Kim, Shefali Chopra, Li Ding, Matthew Thornton, Brendan Grubbs, Leonard Makowka, Linda Sher, Keigo Machida
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1549-1560 (2022)
Abstract The ability of the liver to regenerate after injury makes it an ideal organ to study for potential therapeutic interventions. Mesenchymal stem cells (MSCs) possess self‐renewal and differentiation properties, as well as anti‐inflammatory
Externí odkaz:
https://doaj.org/article/922690c010f1446d8f5cb8b8763f520c
Autor:
Juan Carlos Hernandez, Chia-Lin Chen, Tatsuya Machida, Dinesh Babu Uthaya Kumar, Stanley M. Tahara, Jared Montana, Linda Sher, Jake Liang, Jae U. Jung, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106254- (2023)
Summary: Chemoresistance and plasticity of tumor-initiating stem-like cells (TICs) promote tumor recurrence and metastasis. The gut-originating endotoxin-TLR4-NANOG oncogenic axis is responsible for the genesis of TICs. This study investigated mechan
Externí odkaz:
https://doaj.org/article/226e0646bccf467da2d2c0e828ad246d
Autor:
Nolan Ung, Cameron Goldbeck, Cassandra Man, Julianne Hoeflich, Ren Sun, Arianna Barbetta, Naim Matasci, Jonathan Katz, Jerry S. H. Lee, Shefali Chopra, Shahab Asgharzadeh, Mika Warren, Linda Sher, Rohit Kohli, Omid Akbari, Yuri Genyk, Juliet Emamaullee
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rejection continues to be an important cause of graft loss in solid organ transplantation, but deep exploration of intragraft alloimmunity has been limited by the scarcity of clinical biopsy specimens. Emerging single cell immunoprofiling technologie
Externí odkaz:
https://doaj.org/article/4e0d78655b6b479689062a7acc28f65d
Autor:
Hye Yeon Choi, Hifzur R. Siddique, Mengmei Zheng, Yi Kou, Da-Wei Yeh, Tatsuya Machida, Chia-Lin Chen, Dinesh Babu Uthaya Kumar, Vasu Punj, Peleg Winer, Alejandro Pita, Linda Sher, Stanley M. Tahara, Ratna B. Ray, Chengyu Liang, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for
Externí odkaz:
https://doaj.org/article/b860fba9de8448de8c15f0811ec7cae9
Autor:
Muhammad H. Raza, BS, Navpreet Kaur, MD, Linda Sher, MD, Yuri Genyk, MD, Juliet Emamaullee, MD, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 1, p e1275 (2022)
Externí odkaz:
https://doaj.org/article/893efa80823a48d68fdc10f6caaa7dfa
Autor:
Alejandro Pita, MD, Navpreet Kaur, MD, Juliet Emamaullee, MD, PhD, Mary Lo, MS, Brian Nguyen, MD, Andrew Sabour, BSc, Vincent Tristan, PA-C, Mitra Nadim, MD, Yuri Genyk, MD, Linda Sher, MD
Publikováno v:
Transplantation Direct, Vol 5, Iss 10, p e490 (2019)
Background. As the liver transplant (LT) waiting list continues to outpace organ availability, many patients require renal replacement therapy (RRT) before LT. It is unclear which patients will benefit from simultaneous liver kidney (SLK) transplant
Externí odkaz:
https://doaj.org/article/4a3d0b839b884c26bb042d7c83262471
Autor:
Sujit, Kulkarni, Ralitza, Parina, Randy, Henderson, Elika, Derek, Taylor, Selby, Yong, Kwon, Juliet, Emamaullee, Linda, Sher, Yuri, Genyk, Rick, Selby
Publikováno v:
Annals of Surgery. 277:469-474
Describe the techniques and prove the feasibility of performing complex hepatobiliary and pancreatic surgery on a Jehovah's Witness (JW) population. 2. Describe a strategy that offsets surgical blood loss by the manipulation of circulating blood volu