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of 8
pro vyhledávání: '"Linda Sequeira"'
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 14
International Journal of Molecular Sciences, Vol 21, Iss 4874, p 4874 (2020)
Volume 21
Issue 14
International Journal of Molecular Sciences, Vol 21, Iss 4874, p 4874 (2020)
Osteoporosis is a bone disease that has no definite cure. Current treatments for osteoporosis are divided into two categories: anti-resorptive and anabolic. However, these treatments are not perfect and have considerable risks. In addition, bone qual
Publikováno v:
Indian Journal of Public Health Research & Development. 11:31
Background: Elderabuse has come to the limelight only since the past decade. WHO estimates that 15.7% of individuals above 60 years undergo abuse in various forms and is proposed to increase in the coming years owing to ageing population in many coun
Autor:
Anja Nohe, Lora M Schell, John Nguyen, Saurabh Dharmadhikari, Randall L. Duncan, Liyun Wang, Linda Sequeira, Hilary Weidner, Ryan Kabrick, Harold F Coombs
Publikováno v:
Journal of bone research
Background: Osteoporosis is a silent disease caused by low bone mineral density that results in bone fractures in 1 out of 2 women and 1 in 4 men over the age of 50. Although several treatments for osteopenia and osteoporosis are available, they have
Autor:
Cara W. Dubyk, Linda Sequeira, Surabhi Pathak, Kenneth L. van Golen, Mashariki Jenkins-Kabaila, Moumita Chatterjee
Publikováno v:
Journal of Signal Transduction
The Rho GTPases organize the actin cytoskeleton and are involved in cancer metastasis. Previously, we demonstrated that RhoC GTPase was required for PC-3 prostate cancer cell invasion. Targeted down-regulation of RhoC led to sustained activation of R
Autor:
Chi Ying, Tracy Reisenberger, Cara W. Dubyk, Robert D. Loberg, Kenneth L. van Golen, Linda Sequeira, Arul M. Chinnaiyan, Kenneth J. Pienta
Publikováno v:
Journal of Cellular Biochemistry. 104:1587-1597
Nearly 85% of the men who will die of prostate cancer (PCa) have skeletal metastases present. The ability of PCa cells to interact with the microenvironment determines the success of the tumor cell to form metastatic lesions. The ability to bind to h
Autor:
Linda Sequeira, Carlton R. Cooper, Kenneth L. van Golen, Tracy A. Riesenberger, Cara W. Dubyk
Publikováno v:
Clinical & Experimental Metastasis. 25:569-579
Background The Rho GTPases comprise one of the eight subfamilies of the Ras superfamily of monomeric GTP-binding proteins and are involved in cytoskeletal organization. Previously, using a dominant negative construct, we demonstrated a role for RhoC
Autor:
Linda Sequeira, Fayth L. Miles, Carlton R. Cooper, Karla Rachel Boyd, Mary C. Farach-Carson, Mike Dumas, Bianca Graves, Robert A. Sikes
Publikováno v:
The FASEB Journal. 20
Publikováno v:
Cancer Research. 70:2356-2356
The Rho GTPases are molecular switches intimately involved in cancer metastasis through orchestrating changes in the cytoskeleton leading to motility and invasion. Previously, we demonstrated that RhoC GTPase was sufficient and required for PC-3 pros