Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Linda Schäker-Hübner"'
Autor:
Alica Fischle, Mika Lutsch, Florian Hübner, Linda Schäker-Hübner, Lina Schürmann, Finn K. Hansen, Svetlana A. Kalinina
Publikováno v:
Natural Products and Bioprospecting, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These secondary metabolites have gained significant attention due to their antiprotozoal activity through HDAC inhibition, t
Externí odkaz:
https://doaj.org/article/6949c4f457304e46a17e0c33a1681c9c
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 356 (2023)
Histone deacetylases (HDACs) play a key role in the control of transcription, cell proliferation, and migration. FDA-approved histone deacetylase inhibitors (HDACi) demonstrate clinical efficacy in the treatment of different T-cell lymphomas and mult
Externí odkaz:
https://doaj.org/article/3e7be92decaa49899e026d9800bdcaf8
Autor:
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 324 (2022)
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitor
Externí odkaz:
https://doaj.org/article/830003203e3b458b81afb939ef4979aa
Autor:
Nina Reßing, Julian Schliehe-Diecks, Paris R. Watson, Melf Sönnichsen, Abigail D. Cragin, Andrea Schöler, Jing Yang, Linda Schäker-Hübner, Arndt Borkhardt, David W. Christianson, Sanil Bhatia, Finn K. Hansen
Publikováno v:
Journal of medicinal chemistry. 65(22)
Using a microwave-assisted protocol, we synthesized 16 peptoid-capped HDAC inhibitors (HDACi) with fluorinated linkers and identified two hit compounds. In biochemical and cellular assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c328a1ef9a9552fa48f1a4d563a8adbd
https://pubmed.ncbi.nlm.nih.gov/36351184
https://pubmed.ncbi.nlm.nih.gov/36351184
Autor:
Beate König, Paris R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker-Hübner, David W. Christianson, Finn Kristian Hansen
Histone deacetylase 6 (HDAC6) is an important drug target in oncology and non-oncological diseases. Most available HDAC6 inhibitors (HDAC6i) utilize a hydroxamic acid as zinc-binding group which limits the therapeutic opportunities due its genotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6a59ac364a0a4c932b7e028b29ef18
https://doi.org/10.26434/chemrxiv-2023-6kt1w
https://doi.org/10.26434/chemrxiv-2023-6kt1w
Autor:
Tim Keuler, Beate König, Nico Bückreiß, Fabian B. Kraft, Philipp König, Linda Schäker-Hübner, Christian Steinebach, Gerd Bendas, Michael Gütschow, Finn K. Hansen
Publikováno v:
Chemical Communications. 58:11087-11090
The targeted degradation of histone deacetylase 6 (HDAC6) by heterobifunctional degraders constitutes a promising approach to treat HDAC6-driven diseases. Previous HDAC6 selective degraders utilised a hydroxamic acid as a zinc-binding group (ZBG) whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b75b15bd78c147a2b9c09ce7c7113e
https://doi.org/10.1039/d2cc03712b
https://doi.org/10.1039/d2cc03712b
Autor:
Linda Schäker‐Hübner, Reza Haschemi, Thomas Büch, Fabian B. Kraft, Birke Brumme, Andrea Schöler, Robert Jenke, Jens Meiler, Achim Aigner, Gerd Bendas, Finn K. Hansen
Publikováno v:
ChemMedChem. 17
Herein we report the structure-activity and structure-physicochemical property relationships of a series of class I selective ortho-aminoanilides targeting the "foot-pocket" in HDAC12. To balance the structural benefits and the physicochemical disadv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719df0fdda32b3c206d20d07a15eaf64
https://doi.org/10.1002/cmdc.202100755
https://doi.org/10.1002/cmdc.202100755
Autor:
Thomas Kurz, Finn K. Hansen, Fangyuan Cao, Alexandra Hamacher, Katharina Stenzel, Viktoria Krieger, Holger Gohlke, Linda Schäker-Hübner, Christoph G. W. Gertzen, Matthias U. Kassack, Frank J. Dekker
Publikováno v:
Journal of Medicinal Chemistry, 62(24), 11260-11279. AMER CHEMICAL SOC
There is increasing evidence that histone deacetylase (HDAC) inhibitors can (re)sensitize cancer cells for chemotherapeutics via "epigenetic priming". In this work, we describe the synthesis of a series of class I-selective HDAC inhibitors with 2-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f06d5278800bf3b47de3f8ca97893c6
https://pubmed.ncbi.nlm.nih.gov/31762274
https://pubmed.ncbi.nlm.nih.gov/31762274
Autor:
Bollmann, Lukas M.1 (AUTHOR) lukas.bollmann@hhu.de, Lange, Friedrich1 (AUTHOR), Hamacher, Alexandra1 (AUTHOR), Biermann, Lukas1 (AUTHOR), Schäker-Hübner, Linda2 (AUTHOR) finn.hansen@uni-bonn.de, Hansen, Finn K.2 (AUTHOR), Kassack, Matthias U.1 (AUTHOR) matthias.kassack@uni-duesseldorf.de
Publikováno v:
Cancers. Oct2024, Vol. 16 Issue 19, p3374. 33p.
Autor:
Kraft, Fabian B.1 (AUTHOR), Hanl, Maria1 (AUTHOR), Feller, Felix1 (AUTHOR), Schäker-Hübner, Linda1 (AUTHOR), Hansen, Finn K.1 (AUTHOR) finn.hansen@uni-bonn.de
Publikováno v:
Pharmaceuticals (14248247). Mar2023, Vol. 16 Issue 3, p356. 16p.