Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Linda S. W. Steijns"'
Publikováno v:
Acta neuropsychiatrica. 15(2)
Background:Identification of schizophrenia, a common neuropsychiatric disorder, is based on clinical examination. An easily measurable peripheral marker, which may enable a more rapid and more accurate diagnosis, is not available. A possible candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8942768da1f2d7fae03c5d2a240f70f2
https://pubmed.ncbi.nlm.nih.gov/26984797
https://pubmed.ncbi.nlm.nih.gov/26984797
Publikováno v:
Pharmacogenetics. 13:169-172
Clozapine is an atypical antipsychotic drug that is metabolized to a major extent by the cytochrome P450 enzyme CYP1A2. Smoking is a potent inducer of CYP1A2 enzyme activity, resulting in significant lower clozapine serum concentrations in smokers co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a275b79d6e124a27e4d69e25c846c6
https://doi.org/10.1097/00008571-200303000-00006
https://doi.org/10.1097/00008571-200303000-00006
Autor:
Linda S. W. Steijns, I. Schillevoort, Anthonius de Boer, Raymund A.C. Roos, Paul A. F. Jansen, Jan van der Weide, Hubert G. M. Leufkens
Publikováno v:
Pharmacogenetics. 12:235-240
To study the association between polymorphism of the cytochrome P450 2D6 gene (CYP2D6) and the risk of antipsychotic-induced extrapyramidal syndromes, as measured by the use of antiparkinsonian medication. Data for this case-control study were obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f74e99b7cae09d6a31b8003d7b9e5cc
https://doi.org/10.1097/00008571-200204000-00008
https://doi.org/10.1097/00008571-200204000-00008
Autor:
J. Van Der Weide, Linda S. W. Steijns
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 36:722-729
The cytochrome P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955634fdd0bc0b8539c9653fe8842561
https://doi.org/10.1177/000456329903600604
https://doi.org/10.1177/000456329903600604
Autor:
Jan van der Weide, Linda S. W. Steijns
Publikováno v:
Clinical Chemistry. 44:914-917
The enzyme debrisoquine 4-hydroxylase (CYP2D6), which metabolizes many widely used drugs, is highly polymorphic. The activity of the enzyme ranges between subjects from ultrafast to a complete absence. Therefore, metabolic capacity varies, producing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6042453b3f3eba2b8e6289bb0fd2b5f
https://doi.org/10.1093/clinchem/44.5.914
https://doi.org/10.1093/clinchem/44.5.914
Publikováno v:
Clinica Chimica Acta. 248:135-141
We report the evaluation of the microparticle enzyme immunoassay (MEIA) for estimating vitamin B 12 and the ion capture (IC) assay for estimating folate in serum. The essays were performed with the Abbott IMx analyzer. Intra-assay coefficients of var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be18d5233a96a1aa9b61af7b78dc42d
https://doi.org/10.1016/0009-8981(95)06248-3
https://doi.org/10.1016/0009-8981(95)06248-3
Publikováno v:
Therapeutic drug monitoring. 24(3)
The authors evaluated the fluorescence polarization (FP) assay on the COBAS INTEGRA 700 using COBAS INTEGRA reagent system cassettes for estimating the antiepileptic drugs valproic acid, phenytoin, carbamazepine, and phenobarbital in serum. The study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2b9638963ae1be03607d178b83bdb9
https://pubmed.ncbi.nlm.nih.gov/12021637
https://pubmed.ncbi.nlm.nih.gov/12021637
Publikováno v:
Pharmacogenetics. 11(4)
The cytochrome P450 enzyme CYP2C9 catalyses the metabolism of numerous therapeutic agents, including the anti-epileptic drug phenytoin. CYP2C9 is genetically polymorphic: two allelic variants are known, CYP2C9*2 and CYP2C9*3, differing from the wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7ceacb7800dd2db39bf435956bfb1a
https://pubmed.ncbi.nlm.nih.gov/11434505
https://pubmed.ncbi.nlm.nih.gov/11434505