Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Linda S. Musil"'
Publikováno v:
Developmental Dynamics. 247:1186-1198
BACKGROUND The tissue-specific transcriptional programs during normal development require tight control by distal cis-regulatory elements, such as enhancers, with specific DNA sequences recognized by transcription factors, coactivators, and chromatin
Autor:
Linda S. Musil, Michael Heinrich, Amber E Bannon, Lillian R. Klug, Jonathan A. Fletcher, Ajia Town, William H. Fleming, Nathalie Javidi-Sharifi, Judy K. VanSlyke, Jeffrey W. Tyner
Publikováno v:
Oncogene
Certain cancers, including gastrointestinal stromal tumor (GIST) and subsets of melanoma, are caused by somatic KIT mutations that result in KIT receptor tyrosine kinase constitutive activity, which drives proliferation. The treatment of KIT-mutant G
Publikováno v:
Molecular Biology of the Cell
TGFβ signaling is linked to posterior capsule opacification (PCO), the most common complication of cataract surgery. TGFβ can induce primary lens epithelial cells to differentiate into two disparate, PCO-causing abnormal cell phenotypes, a variatio
Publikováno v:
Developmental Dynamics
Background: The tissue‐specific transcriptional programs during normal development require tight control by distal cis‐regulatory elements, such as enhancers, with specific DNA sequences recognized by transcription factors, coactivators, and chro
Publikováno v:
Journal of cell science. 131(22)
Lens epithelial cells are bound to the lens extracellular matrix capsule, of which laminin is a major component. After cataract surgery, surviving lens epithelial cells are exposed to increased levels of fibronectin, and so we addressed whether fibro
Publikováno v:
Journal of Cell Science.
Lens epithelial cells are bound to the lens extracellular matrix capsule, of which laminin is a major component. After cataract surgery, surviving lens epithelial cells are exposed to increased levels of fibronectin, and so we addressed whether fibro
Autor:
Linda S. Musil, Bruce A. Boswell
Publikováno v:
Molecular Biology of the Cell
Relatively little is known about how receptor tyrosine kinase ligands can positively cooperate with BMP signaling. Primary cultures of lens cells were used to reveal an unprecedented type of cross-talk between the canonical FGF and BMP signaling path
Autor:
Linda S. Musil
Publikováno v:
The Journal of Membrane Biology. 245:357-368
A major limitation in lens gap junction research has been the lack of experimentally tractable ex vivo systems to study the formation and regulation of fiber-type gap junctions. Although immortalized lens-derived cell lines are amenable to both gene
Autor:
Ales Cvekl, Qing Xie, Rebecca McGreal, Chun Y. Gao, Lixing W. Reneker, Raven Harris, Linda S. Musil, Wei Liu
Fibroblast growth factor (FGF) signaling regulates a multitude of cellular processes, including cell proliferation, survival, migration, and differentiation. In the vertebrate lens, FGF signaling regulates fiber cell differentiation characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6f0e9ce8f328be61969193a7094ead
https://europepmc.org/articles/PMC4759173/
https://europepmc.org/articles/PMC4759173/
Publikováno v:
Molecular Biology of the Cell
Using cultured lens epithelial cells, we discovered a new type of cross-talk between the FGF and TGF-β pathways, as well as a novel role for TGF-β and p38 kinase in the regulation of gap junctional intercellular communication. Our findings provide