Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Linda S. Kaltenbach"'
Autor:
Peter H. Reinhart, Linda S. Kaltenbach, Christian Essrich, Denise E. Dunn, Joshua A. Eudailey, C. Todd DeMarco, Gregory J. Turmel, Jennifer C. Whaley, Andrew Wood, Seongeun Cho, Donald C. Lo
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 248-256 (2011)
Huntington's disease (HD) is a late-onset, neurodegenerative disease for which there are currently no cures nor disease-modifying treatments. Here we report the identification of several potential anti-inflammatory targets for HD using an ex vivo mod
Externí odkaz:
https://doaj.org/article/f67d6e594ca04498b24c1f147e59e74f
Autor:
Amber L Southwell, Charles W Bugg, Linda S Kaltenbach, Denise Dunn, Stefanie Butland, Andreas Weiss, Paolo Paganetti, Donald C Lo, Paul H Patterson
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16676 (2011)
Proteolytic processing of mutant huntingtin (mHtt), the protein that causes Huntington's disease (HD), is critical for mHtt toxicity and disease progression. mHtt contains several caspase and calpain cleavage sites that generate N-terminal fragments
Externí odkaz:
https://doaj.org/article/83d61df88355459e91c3326b3f7f65cd
Autor:
Linda S Kaltenbach, Eliana Romero, Robert R Becklin, Rakesh Chettier, Russell Bell, Amit Phansalkar, Andrew Strand, Cameron Torcassi, Justin Savage, Anthony Hurlburt, Guang-Ho Cha, Lubna Ukani, Cindy Lou Chepanoske, Yuejun Zhen, Sudhir Sahasrabudhe, James Olson, Cornelia Kurschner, Lisa M Ellerby, John M Peltier, Juan Botas, Robert E Hughes
Publikováno v:
PLoS Genetics, Vol 3, Iss 5, p e82 (2007)
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involvi
Externí odkaz:
https://doaj.org/article/13bd083a8da44dd192d10530abf31c3c
Autor:
Colúm Connolly, Clemens Steegborn, Donald C. Lo, Albena T. Dinkova-Kostova, Andrew Snyder, Vanita Chopra, Alexei Degterev, Michael A. Schwarzschild, Cho Low, Ulrike Träger, Leslie M. Thompson, Michael J. Van Kanegan, James R. Miller, Matthew Fuszard, Ningzhe Zhang, Ellen Sapp, Susanta Samajdar, Lisa Meisel, Kimberly B. Kegel-Gleason, Petr Vodicka, Adelaide Tousley, Lisa M. Ellerby, David Llères, Sébastien Moniot, Aleksey G. Kazantsev, Steven M. Hersch, Lisa A. Crawford, Ross S. Stein, Sarah J. Tabrizi, Eranthie Weerapana, Vijay Potluri, Linda S. Kaltenbach, Ruth Farmer, Blair R. Leavitt, Maureen Higgins, Luisa Quinti, Marian DiFiglia, Sharadha Dayalan Naidu, Xiqun Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 23
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes. The present study has characterized a triaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bba6be10075b3b40875d35cd1e72bd7
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdf
Autor:
Linda S. Kaltenbach, Russell Bell, Cendrine Tourette, Sean D. Mooney, Shannon O'Hare, Biao Li, Robert E. Hughes
Publikováno v:
Journal of Biological Chemistry. 289:6709-6726
Huntington disease (HD) is an inherited neurodegenerative disease caused by a CAG expansion in the HTT gene. Using yeast two-hybrid methods, we identified a large set of proteins that interact with huntingtin (HTT)-interacting proteins. This network,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37afb173e7edf526885ca1a4093c858d
https://doi.org/10.1074/jbc.m113.523696
https://doi.org/10.1074/jbc.m113.523696
Publikováno v:
Neurotherapeutics. 10:400-415
Huntington’s disease (HD) typifies a class of inherited neurodegenerative disorders in which a CAG expansion in a single gene leads to an extended polyglutamine tract and misfolding of the expressed protein, driving cumulative neural dysfunction an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663999ed97650052cb4d41ffe0d5c8a9
https://doi.org/10.1007/s13311-013-0195-4
https://doi.org/10.1007/s13311-013-0195-4
Publikováno v:
Drug Discovery Today. 17:1217-1223
Huntington's disease (HD) is a progressive and fatal neurodegenerative disease, and the most common inherited CAG repeat disorder. A polyglutamine expansion in the N-terminus of the huntingtin protein (HTT) leads to protein misfolding and downstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f774d944572744c4b75084518d62075
https://doi.org/10.1016/j.drudis.2012.06.017
https://doi.org/10.1016/j.drudis.2012.06.017
Autor:
Jennifer C. Whaley, Denise E. Dunn, Donald C. Lo, Seongeun Cho, Christian Essrich, C. Todd DeMarco, Gregory J. Turmel, Linda S. Kaltenbach, Joshua Eudailey, Peter H. Reinhart, Andrew Wood
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 248-256 (2011)
Huntington’s disease (HD) is a late-onset, neurodegenerative disease for which there are currently no cures nor disease-modifying treatments. Here we report the identification of several potential anti-inflammatory targets for HD using an ex vivo m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d623fe51b91daae1b0cd06832a942151
http://www.sciencedirect.com/science/article/pii/S0969996111000994
http://www.sciencedirect.com/science/article/pii/S0969996111000994
Autor:
C. Todd DeMarco, Denise E. Dunn, Joshua Eudailey, Donald C. Lo, Linda S. Kaltenbach, Thomas G. Gainer, O. Joseph Trask
Publikováno v:
High Content Screening: Science, Techniques and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b496ad84139946b0722d666972e6d53
https://doi.org/10.1002/9780470229866.ch8
https://doi.org/10.1002/9780470229866.ch8
Autor:
Robert A. Newman, Michael J. Van Kanegan, Lin Du, Bijal D. Shah, Daniel D. McCoy, Dong Ning He, Li Shen, Donald C. Lo, Jiangnan Peng, Linda S. Kaltenbach, Peiying Yang, Denise E. Dunn, Robert H. Cichewicz
Publikováno v:
Scientific Reports
We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuropro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9123e7954ed6fe1e8da16cabc426ac
https://pubmed.ncbi.nlm.nih.gov/27172999
https://pubmed.ncbi.nlm.nih.gov/27172999