Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Linda S. Crnic"'
Autor:
Linda S. Crnic, J. John Cohen
Publikováno v:
Stress, Immunity, and Aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8872a336bdb8c711499807cfd7a6c51a
https://doi.org/10.1201/9781003065180-8
https://doi.org/10.1201/9781003065180-8
Autor:
Katherine H. Overdier, Gary Brodsky, Milan Elleder, Rima Rozen, Kenneth N. Maclean, Viktor Kožich, Linda S. Crnic, Lori S. Greiner, Hua Jiang, Lynne Meltesen, Renata Collard, Jakub Krijt, Jakub Sikora, David Patterson, Sally P. Stabler, Robert H. Allen, Eva Kraus, Jan P. Kraus
Publikováno v:
Molecular Genetics and Metabolism
Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine (Hcy) and serine to cystathionine, which is then hydrolyzed to cysteine by cystathionine gamma-lyase. Inactivation of CBS results in CBS-deficient homocystinuria more common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa311a214521f5b818ba15f40c7edef
Publikováno v:
Journal of Inherited Metabolic Disease. 29:612-619
Glutaric acidaemia type I (GA I) is an inborn error of metabolism caused by a deficiency of glutaryl-CoA dehydrogenase (GCDH) and is characterized clinically by striatal degeneration that almost always occurs in early childhood. A murine knockout mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4622402fe30e7b308cf3301e3d8cd282
https://doi.org/10.1007/s10545-006-0102-9
https://doi.org/10.1007/s10545-006-0102-9
Autor:
Lori L. Driscoll, David A. Levitsky, Jisook Moon, Barbara J. Strupp, Linda S. Crnic, Jenna C. Carroll
Publikováno v:
Behavioral Neuroscience. 118:1196-1205
This study compared performance of 15- to 17-month-old Ts65Dn mice to that of littermate controls on an automated sustained attention task in which the location, onset time, and duration of brief visual cues varied unpredictably. Ts65Dn mice committe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7382e8830ec92d8cc7e004cbb166b754
https://doi.org/10.1037/0735-7044.118.6.1196
https://doi.org/10.1037/0735-7044.118.6.1196
Publikováno v:
Briefings in Functional Genomics and Proteomics. 3:142-156
Now that the complete sequences for human chromosome 21 and the orthologous mouse genomic regions are known, reasonably complete, conserved, protein-coding gene catalogues are also available. The central issue now facing Down's syndrome researchers i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67270e051cd46261cb0f8ae1722492bb
https://doi.org/10.1093/bfgp/3.2.142
https://doi.org/10.1093/bfgp/3.2.142
Autor:
Ann-Charlotte Granholm, Linda Sanders, Heather A. Bimonte, Linda S. Crnic, Matthew E. Nelson, Elliott J. Mufson, David Albeck, Lynn A. Hyde, Kerstin A. Ford, Christopher L. Hunter
Publikováno v:
Physiology & Behavior. 77:371-385
Estrogen maintains normal function of basal forebrain (BF) cholinergic neurons and estrogen replacement therapy (ERT) has therefore been proposed as a therapy for Alzheimer's disease (AD). We provide evidence to support this hypothesis in an animal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f3669ccb14800e9242ba30bd85ab73
https://doi.org/10.1016/s0031-9384(02)00884-3
https://doi.org/10.1016/s0031-9384(02)00884-3
Publikováno v:
Current Paediatrics. 12:316-324
Fragile X syndrome (FXS), the most common form of inherited mental retardation, results from a mutation that silences transcription of the F ragile X Mental R etardation gene ( FMRI ), and translation of the FMRI protein ( FMRP ). Individuals with FX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1624997e1a13c9d2c51433a27d000a2
https://doi.org/10.1054/cupe.2002.0305
https://doi.org/10.1054/cupe.2002.0305
Autor:
Lynn A. Hyde, Linda S. Crnic
Publikováno v:
Brain Research. 945:26-30
Ts65Dn mice, a model for Down syndrome and Alzheimer's disease, have a spontaneous age-related reduction of cholinergic markers in medial septal neurons, hippocampal abnormalities, and an age-related learning deficit in a task that requires an intact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d910ab5b5ca76b58538d66364a9b5727
https://doi.org/10.1016/s0006-8993(02)02500-3
https://doi.org/10.1016/s0006-8993(02)02500-3
Autor:
Darci M. Nielsen, Linda S. Crnic
Publikováno v:
Journal of Neuroscience Methods. 115:199-209
Foot-shock is used in a variety of behavioral tasks either as a motivational stimulus, a way to characterize different rodents, or to test various pharmacological agents for their antinociceptive or analgesic effects. All these procedures need to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a50626c5a846e828a19fc8e1c43f7b
https://doi.org/10.1016/s0165-0270(02)00020-1
https://doi.org/10.1016/s0165-0270(02)00020-1
Autor:
Bette K. Kleinschmidt-DeMasters, Linda S. Crnic, Janet K. Stephens, Stephen I. Goodman, David M. Koeller, Edgar L. Hunt, Michael Woontner
Publikováno v:
Human Molecular Genetics. 11:347-357
Glutaric acidemia type I (GA-I) is an autosomal recessive disorder of amino acid metabolism resulting from a deficiency of glutaryl-CoA dehydrogenase (GCDH). Patients accumulate glutaric acid (GA) and 3-OH glutaric acid (3-OHGA) in their blood, urine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fe3cd8f286503f0adece3de642dc52
https://doi.org/10.1093/hmg/11.4.347
https://doi.org/10.1093/hmg/11.4.347