Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Linda S Lashford"'
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Results of a Randomized Study of Preradiation Chemotherapy Versus Radiotherapy Alone for Nonmetastatic Medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children’s Cancer Study Group PNET-3 Study
Autor: Roger E. Taylor, David W. Ellison, J. Imeson, James W. Ironside, Clifford C. Bailey, H Lucraft, Linda S Lashford, Barry Pizer, Claire Weston, David Walker, Richard J. Gilbertson, Diana Tait, K. Robinson
Publikováno v: Journal of Clinical Oncology. 21:1581-1591
Purpose: To determine whether preradiotherapy (RT) chemotherapy would improve outcome for Chang stage M0–1 medulloblastoma when compared with RT alone. Chemotherapy comprised vincristine 1.5 mg/m2 weekly for 10 weeks and four cycles of etoposide 10
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64678511180608fbebc9866a3fb09ec2
https://doi.org/10.1200/jco.2003.05.116
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2
Assays to predict the genotoxicity of the chromosomal mutagen etoposide — focussing on the best assay
Autor: Linda S Lashford, Susan W.P. Wijnhoven, John Ashby, Helen Tinwell, Joseph A Rafferty, Suzanne D. Turner, Harry Vrieling, Leslie J. Fairbairn
Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 493:139-147
The topoisomerase II inhibitor etoposide is used routinely to treat a variety of cancers in patients of all ages. As a result of its extensive use in the clinic and its association with secondary malignancies it has become a compound of great interes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e34df01440b181645e055cf57891d9
https://doi.org/10.1016/s1383-5718(01)00170-x
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3
The effects of dose, route of administration, drug scheduling and MDR-1 gene transfer on the genotoxicity of etoposide in bone marrow
Autor: Suzanne D. Turner, John Ashby, Linda S Lashford, Leslie J. Fairbairn, H. Tinwell, Christopher Baum, Joseph A Rafferty, H G Eckert
Publikováno v: Leukemia. 14:1796-1802
We have used the bone marrow micronucleus assay (BMMN) as a measure of clastogenicity, in response to etoposide exposure in murine bone marrow. Oral delivery of etoposide resulted in a reduced number of micronucleated polychromatic erythrocytes (MPE)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0e8ce80f6977c8bf90d332da4d2cad
https://doi.org/10.1038/sj.leu.2401810
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4
Development of synthetic promoters for radiation-mediated gene therapy
Autor: Brian Marples, M J Embleton, Jolyon H Hendry, Geoffrey P. Margison, Simon D. Scott, Linda S Lashford
Publikováno v: Gene Therapy. 7:511-517
Exposure of cells to ionising radiation results in the activation of specific transcriptional control (CArG) elements within the early growth response 1 (Egr1) gene promoter, leading to increased gene expression. As part of a study investigating the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e108f669c937f89b3144e04a263cd81d
https://doi.org/10.1038/sj.gt.3301116
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5
Leptomeningeal melanoma in childhood
Autor: Linda S. Lashford, Helena Davies, Mary Gerrard, H. Frances Child, Guy Makin, Alastair N. Campbell, Colin V. E. Powell, Osborn B. Eden, John Moppett
Publikováno v: Cancer. 86:878-886
BACKGROUND Malignant melanoma (MM) is one of the least common types of childhood cancer, accounting for less than 1% of all pediatric malignancies. Neurocutaneous melanosis (NCM) is a rare phakomatosis consisting of congenital abnormal pigmentation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad96fb996d0e66301f38aa188c1a3c37
https://doi.org/10.1002/(sici)1097-0142(19990901)86:5<878::aid-cncr26>3.0.co
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6
Phase I study of temozolomide in paediatric patients with advanced cancer
Autor: Pascale Reidenberg, A Marco, Ian Lewis, Adj Pearson, M Mott, S Ablett, Vijay Batra, C. Dicks-Mireaux, R. Gowing, Linda S Lashford, Bruce Morland, Richard F. Stevens, Mcg Stevens, CR Pinkerton, J.A. Kohler, Margaret Dugan, A Gholkar, D. Walker, L. Price, Heather P. McDowell, Paul Statkevich, EJ Estlin, Newell
Publikováno v: British Journal of Cancer. 78:652-661
A phase I study of temozolomide administered orally once a day, on 5 consecutive days, between 500 and 1200 mg m(-2) per 28-day cycle was performed. Children were stratified according to prior craniospinal irradiation or nitrosourea therapy. Sixteen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f161599a605f39350c4b8eb29f8a8889
https://doi.org/10.1038/bjc.1998.555
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8
Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants
Autor: T. Michael Dexter, Nydia G Testa, Claire Hatton, Michael Cross, Andrew M. Will, Robert Wynn, Linda S Lashford
Publikováno v: The Lancet. 351:178-181
Summary Background The establishment of donor-derived haemopoiesis in the recipients of allogeneic bone-marrow transplants (BMT) involves extensive proliferation of haemopoietic stem cells. The biological consequences of this replicative stress are i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabda9d9c24b2095da94e64d9634f801
https://doi.org/10.1016/s0140-6736(97)08256-1
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9
Possibilities of Gene Therapies for Cancer
Autor: Linda S. Lashford
Publikováno v: Annals of Medicine. 29:1-4
Cancer is an acquired disease in which it is possible to identify a variety of abnormalities at a genetic level. This holds a promise that genetic manipulation of tumour cells will lead to novel therapies. As yet these approaches are constrained by a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ea4042f5922850127a9752aa86d0f8
https://doi.org/10.3109/07853899708998737
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10
Long-term in vitro correction of alpha-L-iduronidase deficiency (Hurler syndrome) in human bone marrow
Autor: J. R. Arrand, G. T. N. Besley, James E. Wraith, T. M. Dexter, Elaine Spooncer, Linda S Lashford, Alan Cooper, D. S. Anson, C. E. Hatton, J. E. Arrand, G. Lebens, John J. Hopwood, Ilaria Bellantuono, R. H. McDermott, R. Holt, Leslie J. Fairbairn
Publikováno v: Proceedings of the National Academy of Sciences. 93:2025-2030
Allogeneic bone marrow transplantation is the most effective treatment for Hurler syndrome but, since this therapy is not available to all patients, we have considered an alternative approach based on transfer and expression of the normal gene in aut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec05cddd0ff71220eda0725df57c180
https://doi.org/10.1073/pnas.93.5.2025
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