Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Linda Rickardson"'
Autor:
Marita Högberg, Linda Rickardson, Marko J. Kallio, Emma Kutvonen, Stefan Rehnmark, Satu Orasniemi
Publikováno v:
Drug Design, Development and Therapy
Linda Rickardson,1 Emma Kutvonen,2 Satu Orasniemi,2 Marita Högberg,1 Marko J Kallio,2,3 Stefan Rehnmark1 1Noviga Research AB, Södertälje, Sweden; 2Department of Physiology, Institute of Biomedicine, University of Turku, 3Centre for Biotechnology,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ff6879a9863f1fe776f67fd9ab9b52
http://europepmc.org/articles/PMC5417661
http://europepmc.org/articles/PMC5417661
Autor:
Liesbeth Hovestad, Martin Höglund, Malin Jarvius, R. Hilhorst, Mårten Fryknäs, Rik de Wijn, Fredrik Öberg, Anna Eriksson, Vendela Parrow, Linda Rickardson, Antonia Kalushkova, Rolf Larsson, Hanna Göransson Kultima
Publikováno v:
Biochemical Pharmacology. 87(2):284-291
AKN-028 is a novel tyrosine kinase inhibitor with preclinical activity in acute myeloid leukemia (AML), presently undergoing investigation in a phase I/II study. It is a potent inhibitor of the FMS-like kinase 3 (FLT3) but shows in vitro activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98b6ae00e21a58be94baf3f22deea48
Autor:
Padraig D'Arcy, Karolina Lesiak-Mieczkowska, Joachim Gullbo, Caroline Haglund, Lars Bohlin, Stig Linder, Jenny Felth, Linda Rickardson, Rolf Larsson, Mårten Fryknäs
Publikováno v:
Investigational New Drugs. 31:587-598
Gambogic acid (GA), displays cytotoxicity towards a wide variety of tumor cells and has been shown to affect many important cell-signaling pathways. In the present work, we investigated the mechanism of action of GA by analysis of drug-induced change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7044f8afa6c5528ebfdd36e08ae5b5
https://doi.org/10.1007/s10637-012-9902-y
https://doi.org/10.1007/s10637-012-9902-y
Autor:
Jenny Felth, Bengt Glimelius, Stig Linder, Mårten Fryknäs, Wilhelm Graf, Saadia Bashir Hassan, Joachim Gullbo, Peter Nygren, Linda Rickardson, Lars Påhlman, Daniel Laryea, Walid Fayad, Haile Mahteme, Rolf Larsson
Publikováno v:
Cancer Science. 102:2206-2213
A high-throughput screen of the cytotoxic activity of 2000 molecules from a commercial library in three human colon cancer cell lines and two normal cell types identified the acridine acriflavin to be a colorectal cancer (CRC) active drug. Acriflavin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff43964be2721be3aaecbc95b167c5af
https://doi.org/10.1111/j.1349-7006.2011.02097.x
https://doi.org/10.1111/j.1349-7006.2011.02097.x
Autor:
Stig Linder, Caroline Haglund, Mårten Fryknäs, Walid Fayad, Padraig D'Arcy, Maria Hägg Olofsson, Linda Rickardson, Rolf Larsson
Publikováno v:
Chemical Biology & Drug Design. 78:547-557
Cell-based anticancer drug screening generally utilizes rapidly proliferating tumour cells grown as monolayer cultures. Hit compounds from such screens are not necessarily effective on hypoxic and slowly proliferating cells in 3-D tumour tissue. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad79b8f6c7cea68b3c4a237fba09b13c
https://doi.org/10.1111/j.1747-0285.2011.01170.x
https://doi.org/10.1111/j.1747-0285.2011.01170.x
Autor:
Joachim Gullbo, Malin Wickström, Jenny Felth, Linda Rickardson, Lars Bohlin, Mårten Fryknäs, Josefin Rosén, Magnus Lindskog
Publikováno v:
Journal of Natural Products. 72:1969-1974
Cardiac glycosides have been reported to exhibit cytotoxic activity against several different cancer types, but studies against colorectal cancer are lacking. In a screening procedure aimed at identifying natural products with activity against colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdb2a7e850843ebb99d76d8f51bc0ba
https://doi.org/10.1021/np900210m
https://doi.org/10.1021/np900210m
Autor:
Rolf Larsson, Josefin Rosén, Anders Backlund, Joachim Gullbo, Linda Rickardson, Johan Gottfries, Lars Bohlin
Publikováno v:
QSAR & Combinatorial Science. 28:436-446
Chemical space is basically infinite, and comprises all molecules that could possibly exist. Intelligent ways to efficiently navigate through chemical space and to select promising compounds in drug discovery are important tasks, and the focus of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c4931b394898539f9b0c037e6007ebf
https://doi.org/10.1002/qsar.200810162
https://doi.org/10.1002/qsar.200810162
Autor:
Jacob Westman, Aleksandra Mandic Havelka, Mélanie Beaujouin, Rolf Larsson, Stig Linder, Maria Berndtsson, Emmanuelle Liaudet-Coopman, Linda Rickardson
Publikováno v:
International Journal of Cancer. 124:1463-1469
The lysosomal apoptosis pathway is a potentially interesting therapeutic target. Since apoptosis involving the lysosomal pathway has been described to involve cathepsins, we screened a drug library for agents that induce cathepsin-dependent apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d22deac71e3c0305d0ae689bee20305
https://doi.org/10.1002/ijc.24004
https://doi.org/10.1002/ijc.24004
Autor:
Lorenzo M. Leoni, Peter Nygren, Linda Rickardson, Elin Lindhagen, Gary Elliott, Anna Åleskog, Rolf Larsson
Publikováno v:
Investigational New Drugs. 25:297-303
SDX-308 and SDX-309 are potent indole-pyran analogues of SDX-101 (R-etodolac) which has anti-tumour activity unrelated to cyclooxygenase-2 inhibition. Their cytotoxic activity was further studied herein using a well-characterized human tumour cell-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7f22b8dea6219be3ffb739bc7cd3ae
https://doi.org/10.1007/s10637-007-9049-4
https://doi.org/10.1007/s10637-007-9049-4
Publikováno v:
SLAS Discovery. 12:203-210
The proteasome is a new, interesting target in cancer drug therapy, and the proteasome inhibitor bortezomib has shown an effect in myeloma patients. It is of interest to efficiently discover and evaluate new proteasome inhibitors. The authors describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d30738da6aa1721b58a99b842cc445
https://doi.org/10.1177/1087057106297115
https://doi.org/10.1177/1087057106297115