Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linda Rabin"'
Autor:
Robert Lee, Bin Du, Andrea Wolf, Lishan Su, Jennifer Auten, Linda Rabin, Ernest F. Terwilliger, Hideto Kaneshima, Joseph M. McCune, Mark Bonyhadi, Beatrice H. Hahn
Publikováno v:
Virology. 227:45-52
Pathogenic organisms are frequently attenuated after long-term culture in vitro. The mechanisms of the attenuation process are not clear, but probably involve mutations of functions required for replication and pathogenicity in vivo. To identify thes
Autor:
Linda Rabin, J Seifert, S Warren, B Rosenwirth, M Hincenbergs, R Datema, Mary Beth Moreno, V Linquist, Joseph M. McCune
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:750-754
SID 791, a bicyclam inhibiting human immunodeficiency virus (HIV) replication in vitro by blocking virus entry into cells, is an effective inhibitor of virus production and of depletion of human CD4+ T cells in HIV type 1-infected SCID-hu Thy/Liv mic
Autor:
Daniel A. Brown, Suzan Salimi, Mark Bonyhadi, Joseph M. McCune, Hideto Kaneshima, Jon C. Kosek, Linda Rabin
Publikováno v:
Nature. 363:728-732
Human immunodeficiency virus (HIV) disease is typified by declining CD4+ T lymphocyte counts in the peripheral circulation, a loss which may be secondary to accelerated destruction, to suppressed differentiation, and/or to sequestration of circulatin
Publikováno v:
Immunological Reviews. 124:45-62
Work in the SCID-hu system has progressed significantly over the past 3-4 years. Reliable SCID-hu constructs can now be created for the evaluation of long-term multilineage human hematopoiesis, human immune function, and HIV infection of human hemato
Autor:
Reiko Namikawa, Linda Rabin, Stella G. Machado, Hideto Kaneshima, Joseph M. McCune, Henry Outzen, Chu-Chih Shih
Publikováno v:
Proceedings of the National Academy of Sciences. 88:4523-4527
The SCID-hu mouse is a small animal in which human hematolymphoid organs can be engrafted and maintained in vivo. In this study, parameters are described for reproducible infection of SCID-hu mice after i.v. inoculation. Infection was found to be dep
Autor:
Reiko Namikawa, Miriam Lieberman, Linda Rabin, Joseph M. McCune, J F Krowka, Bruno Péault, EJ Yee, C.-C. Shih, Hideto Kaneshima, Henry Outzen
Publikováno v:
Annual Review of Immunology. 9:399-429
The SCID-hu mouse is a heterochimeric small animal model designed to support hematopoietic differentiation and function in vivo. Multiple organs of the human hematolymphoid system have been successfully engrafted into the immunodeficient C.B-17 scid
Publikováno v:
Science. 250:1152-1154
Publikováno v:
Science. 247:564-566
The SCID-hu mouse, engrafted with human hematolymphoid organs, is permissive for infection with the human immunodeficiency virus (HIV). This mouse model was used to test compounds for antiviral efficacy. Two weeks after infection with HIV, 100 percen
Autor:
Mara Hincenbergs, Linda Rabin, Mary E. Moreno, Lo Anne Truong, David J. Ecker, Valerie Linquist-Stepps, Cheryl A. Stoddart, Janet M. Leeds, Jacqueline R. Wyatt, Joseph M. McCune
Publikováno v:
Antimicrobial agents and chemotherapy. 42(8)
Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activi
Autor:
Linda Rabin, Hideto Kaneshima, S Warren, Joseph M. McCune, V Linquist, J Seifert, R Datema, M Hincenbergs, Mary Beth Moreno, B Charpiot
We have developed standardized procedures and practices for infection of SCID-hu Thy/Liv mice with human immunodeficiency virus type 1 for the prophylactic administration of antiviral compounds and for evaluation of the antiviral effect in vivo. Endp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e14dde5d295a6e815ab29e1d9725119
https://europepmc.org/articles/PMC163193/
https://europepmc.org/articles/PMC163193/