Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Linda R. Petzold"'
Autor:
Tal Sharf, Tjitse van der Molen, Stella M. K. Glasauer, Elmer Guzman, Alessio P. Buccino, Gabriel Luna, Zhuowei Cheng, Morgane Audouard, Kamalini G. Ranasinghe, Kiwamu Kudo, Srikantan S. Nagarajan, Kenneth R. Tovar, Linda R. Petzold, Andreas Hierlemann, Paul K. Hansma, Kenneth S. Kosik
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo
Externí odkaz:
https://doaj.org/article/1a831103646e472ea1752f04f8973be1
Autor:
Elmer Guzman, Zhuowei Cheng, Paul K. Hansma, Kenneth R. Tovar, Linda R. Petzold, Kenneth S. Kosik
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We developed a method to non-invasively detect synaptic relationships among neurons from in vitro networks. Our method uses microelectrode arrays on which neurons are cultured and from which propagation of extracellular action potentials (eA
Externí odkaz:
https://doaj.org/article/6ac560e02a154a589e0c0676a99ca60d
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Approximate Bayesian Computation (ABC) has become a key tool for calibrating the parameters of discrete stochastic biochemical models. For higher dimensional models and data, its performance is strongly dependent on having a repre
Externí odkaz:
https://doaj.org/article/8f6d9427573a4f6b978b3dd72d6bcf41
Autor:
Grant Navid Doering, Brian Drawert, Carmen Lee, Jonathan N. Pruitt, Linda R. Petzold, Kari Dalnoki-Veress
Publikováno v:
Royal Society Open Science, Vol 9, Iss 3 (2022)
Biology is suffused with rhythmic behaviour, and interacting biological oscillators often synchronize their rhythms with one another. Colonies of some ant species are able to synchronize their activity to fall into coherent bursts, but models of this
Externí odkaz:
https://doaj.org/article/a92b6dd9f3c241e8b546712f25e459a0
Autor:
St. Elmo Wilken, Jonathan M. Monk, Patrick A. Leggieri, Christopher E. Lawson, Thomas S. Lankiewicz, Susanna Seppälä, Chris G. Daum, Jerry Jenkins, Anna M. Lipzen, Stephen J. Mondo, Kerrie W. Barry, Igor V. Grigoriev, John K. Henske, Michael K. Theodorou, Bernhard O. Palsson, Linda R. Petzold, Michelle A. O’Malley
Publikováno v:
mSystems, Vol 6, Iss 1 (2021)
ABSTRACT Anaerobic gut fungi in the phylum Neocallimastigomycota typically inhabit the digestive tracts of large mammalian herbivores, where they play an integral role in the decomposition of raw lignocellulose into its constitutive sugar monomers. H
Externí odkaz:
https://doaj.org/article/fccac7e8ae6141e8ab56f68f9ad37092
Publikováno v:
Frontiers in Computational Neuroscience, Vol 14 (2020)
Cerebrospinal fluid (CSF) and brain tissue sodium levels increase during migraine. However, little is known regarding the underlying mechanisms of sodium homeostasis disturbance in the brain during the onset and propagation of migraine. Exploring the
Externí odkaz:
https://doaj.org/article/528da1f6d8524d37ae42022f20fee3cc
Autor:
John W. Keyloun, Tuan D. Le, Thomas Orfeo, Kathleen E. Brummel-Ziedins, Maria C. Bravo, Matthew D. Kaye, Dana E. Bourne, Bonnie C. Carney, Kalev Freeman, Kenneth G. Mann, Anthony E. Pusateri, Jeffrey W. Shupp, Melissa M. McLawhorn, Lauren T. Moffatt, Rachael A. Callcut, Mitchell J. Cohen, Linda R. Petzold, Jeffrey D. Varner, Maria Cristina Bravo, Aarti Gautam, Rasha Hammamieh, Marti Jett
Publikováno v:
Journal of Surgical Research. 274:169-177
Proposed mechanisms of acute traumatic coagulopathy (ATC) include decreased clotting potential due to factor consumption and proteolytic inactivation of factor V (FV) and activated factor V (FVa) by activated protein C (aPC). The role of FV/FVa deple
Autor:
Adrian Buganza Tepole, William W. Lytton, Linda R. Petzold, William R. Cannon, Salvador Dura-Bernal, Ellen Kuhl, Mark Alber, George Em Karniadakis, Krishna Garikipati, Suvranu De, Paris Perdikaris
Publikováno v:
npj Digital Medicine, Vol 2, Iss 1, Pp 1-11 (2019)
NPJ digital medicine, vol 2, iss 1
NPJ Digital Medicine
NPJ digital medicine, vol 2, iss 1
NPJ Digital Medicine
Fueled by breakthrough technology developments, the biological, biomedical, and behavioral sciences are now collecting more data than ever before. There is a critical need for time- and cost-efficient strategies to analyze and interpret these data to
Autor:
Linda R. Petzold, Nina Lauharatanahirun, Brian Mitchell, Nicholas F. Wymbs, Scott T. Grafton, Javier O. Garcia, Jean M. Vettel
Publikováno v:
Neural computation, vol 31, iss 10
Even highly trained behaviors demonstrate variability, which is correlated with performance on current and future tasks. An objective of motor learning that is general enough to explain these phenomena has not been precisely formulated. In this six-w
Autor:
Tal, Sharf, Tjitse, van der Molen, Stella M K, Glasauer, Elmer, Guzman, Alessio P, Buccino, Gabriel, Luna, Zhuowei, Cheng, Morgane, Audouard, Kamalini G, Ranasinghe, Kiwamu, Kudo, Srikantan S, Nagarajan, Kenneth R, Tovar, Linda R, Petzold, Andreas, Hierlemann, Paul K, Hansma, Kenneth S, Kosik
Publikováno v:
Nature communications. 13(1)
Human brain organoids replicate much of the cellular diversity and developmental anatomy of the human brain. However, the physiology of neuronal circuits within organoids remains under-explored. With high-density CMOS microelectrode arrays and shank