Zobrazeno 1 - 10
of 529
pro vyhledávání: '"Linda R Watkins"'
Autor:
John Paul Christianson, Johanna G. Flyer-Adams, Robert C Drugan, Jose eAmat, Rachel A Daut, Allison R Foilb, Linda R Watkins, Steven F Maier
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
Behaviorally controllable stressors confer protection from the neurochemical and behavioral consequences of future uncontrollable stressors, a phenomenon termed behavioral immunization. Recent data implicate neuroplasticity within the ventromedial pr
Externí odkaz:
https://doaj.org/article/22661a49efaa427dabe11839df05d663
Autor:
Xiaohui Wang, Zeno Fiorini, Christina Smith, Yingning Zhang, Jing Li, Linda R Watkins, Hang Yin
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47703 (2012)
The lateral transmembrane protein-protein interactions (PPI) have been regarded as "undruggable" despite their importance in many essential biological processes. The homo-trimerization of transmembrane domain 5 (TMD-5) of latent membrane protein 1 (L
Externí odkaz:
https://doaj.org/article/39b3b01e51b049e7b14c77bee166ebab
Autor:
Jayson B. Ball, Connor J. McNulty, Suzanne M. Green-Fulgham, Joseph M. Dragavon, Igor R. Correia Rocha, Maggie R. Finch, Emily D. Prévost, Imaad I. Siddique, Brodie J. Woodall, Linda R. Watkins, Michael V. Baratta, David H. Root
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
A challenge for central nervous system (CNS) tissue analysis in neuroscience research has been the difficulty to codetect and colocalize gene and protein expression in the same tissue. Given the importance of identifying gene expression relative to p
Externí odkaz:
https://doaj.org/article/853326147cf740d7bc6e261533903e46
Autor:
Andrew J. Kwilasz, Madison A. Clements, Tracey A. Larson, Kevin M. Harris, Scott T. Litwiler, Brodie J. Woodall, Laurel S. Todd, Anouk E. W. Schrama, Eric H. Mitten, Steven F. Maier, Anne-Marie Van Dam, Kenner C. Rice, Linda R. Watkins
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Up to 92% of patients suffering from multiple sclerosis (MS) experience pain, most without adequate treatment, and many report pain long before motor symptoms associated with MS diagnosis. In the most commonly studied rodent model of MS, experimental
Externí odkaz:
https://doaj.org/article/f69561aa0381439c90004b4abc048684
Autor:
Hongyuan Li, Yinghua Peng, Cong Lin, Xiaozheng Zhang, Tianshu Zhang, Yibo Wang, Yuanpeng Li, Siru Wu, Hongshuang Wang, Mark R. Hutchinson, Linda R. Watkins, Xiaohui Wang
Publikováno v:
The Innovation, Vol 2, Iss 2, Pp 100111- (2021)
Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs. Nicotine attenuates the neuroinflammation induced by microglial activation. However, the molecular target(s) underlying
Externí odkaz:
https://doaj.org/article/f3383c10e3014292912d72c6a373fc52
Publikováno v:
PAIN Reports, Vol 6, Iss 1, p e905 (2021)
Abstract. Chronic pain is an unpleasant and debilitating condition that is often poorly managed by existing therapeutics. Reciprocal interactions between the nervous system and the immune system have been recognized as playing an essential role in th
Externí odkaz:
https://doaj.org/article/d68e8e6c7857418e9c20eaefced0f1ad
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS). Previous studies have demonstrated that loss of TDP-43 function leads to intracellular accumulati
Externí odkaz:
https://doaj.org/article/3eec52716bdc4c29981471203c340e11
Autor:
Nabanita Das, Varun Dewan, Peter M. Grace, Robin J. Gunn, Ryo Tamura, Netanel Tzarum, Linda R. Watkins, Ian A. Wilson, Hang Yin
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1128-1140 (2016)
Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced g
Externí odkaz:
https://doaj.org/article/e602c673df734870a6cf62b00c8db8d4
Autor:
Suzanne M. Green-Fulgham, Michael E. Harland, Jayson B. Ball, Jiahe Li, Michael J. Lacagnina, Heather D'Angelo, Renee A. Dreher, Kendal F. Willcox, Sabina A. Lorca, Andrew J. Kwilasz, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Publikováno v:
Pain. 163:1939-1951
Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive. Given that exercise acutely increases the formation of free radicals, triggering antioxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9426a45a41a52f9e1117fa276bc989
https://doi.org/10.1097/j.pain.0000000000002589
https://doi.org/10.1097/j.pain.0000000000002589
Publikováno v:
Progress in neurobiology. 218
Microglia shape synaptic connections among neurons of the central nervous system (CNS) during development and adulthood. In this review, the actions by which they facilitate pruning, refinement, and new synaptic development throughout the lifespan ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4daf785506ae77427ae7481c1dc61a4
https://pubmed.ncbi.nlm.nih.gov/35940391
https://pubmed.ncbi.nlm.nih.gov/35940391