Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Linda R Gooding"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119256 (2015)
Credible but conflicting reports address the frequency of prenatal infection by species C adenovirus. This question is important because these viruses persist in lymphoid cells and suppress double-stranded DNA-break repair. Consequently, prenatal ade
Externí odkaz:
https://doaj.org/article/e6e619d6faee4b669e2f2106d3b00a27
Autor:
David A. Ornelles, Kelsey L. Lynch, Daphne C. Avgousti, Linda R. Gooding, Charlie Garnett-Benson
Publikováno v:
FEBS letters. 593(24)
The DNA genome of eukaryotic cells is compacted by histone proteins within the nucleus to form chromatin. Nuclear-replicating viruses such as adenovirus have evolved mechanisms of chromatin manipulation to promote infection and subvert host defenses.
Publikováno v:
Journal of Virology. 84:8799-8810
Species C adenovirus establishes a latent infection in lymphocytes of the tonsils and adenoids. To understand how this lytic virus is maintained in these cells, four human lymphocytic cell lines that support the entire virus life cycle were examined.
Autor:
David A. Ornelles, Charlie T. Garnett, Linda R. Gooding, Yu Zhang, Ganesh R. Talekar, Jeffrey A. Mahr, W Huang
Publikováno v:
Journal of Virology. 83:2417-2428
Although species C human adenoviruses establish persistent infections, the molecular details of this lifestyle remain poorly understood. We previously reported that adenovirus DNA is found in human mucosal T lymphocytes in a noninfectious form (C. T.
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119256 (2015)
PLoS ONE
PLoS ONE
Credible but conflicting reports address the frequency of prenatal infection by species C adenovirus. This question is important because these viruses persist in lymphoid cells and suppress double-stranded DNA-break repair. Consequently, prenatal ade
Publikováno v:
Journal of Virology. 77:1112-1119
The group C adenoviruses typically cause acute respiratory disease in young children. In addition, a persistent phase of infection has been observed in which virus may be shed for years without producing overt pathology. Our laboratory recently repor
Publikováno v:
Journal of Virology. 76:10608-10616
The common species C adenoviruses (serotypes Ad1, Ad2, Ad5, and Ad6) infect more than 80% of the human population early in life. Following primary infection, the virus can establish an asymptomatic persistent infection in which infectious virions are
Publikováno v:
Journal of Virology. 76:9716-9723
Human group C adenoviruses cause an acute infection in respiratory epithelia and establish a long-term or persistent infection, possibly in lymphocytes. The mechanism by which this persistence is maintained is unknown; however, it would require that
Autor:
Paula S. Norris, Chris A. Benedict, Theodore I. Prigozy, Jürg Tschopp, Carl F. Ware, Jean-Luc Bodmer, Fabio Martinon, Jeffrey A. Mahr, Linda R. Gooding, Charlese T. Garnett
Publikováno v:
Journal of Biological Chemistry. 276:3270-3278
Adenovirus encodes multiple gene products that regulate proapoptotic cellular responses to viral infection mediated by both the innate and adaptive immune systems. The E3-10.4K and 14.5K gene products are known to modulate the death receptor Fas. In
Autor:
U von Doblen, Emma Honkaniemi, M Engvall, Linda R. Gooding, David A. Ornelles, Ganesh R. Talekar, Erik Forestier, Gordana Bogdanovic, W Huang, Britt Gustafsson
Publikováno v:
British Journal of Cancer
Background: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. Methods: Guthrie cards from 243 children who later developed ALL and from 486 matc